Table 2 Top 10 selected enriched pathways of interest in fEVs compared to aEVs in the gene ontology (GO) analysis (P-adj < 0.05)
No | GO Accession ID | GO Name | Gene Symbols | FDR P.adjust |
|---|---|---|---|---|
1 | GO:0030199 | Collagen fibril organization | COL5A2/PXDN/COL3A1/ COL1A1/ANXA2/EMILIN1 | 5.1E-07 |
2 | GO:0006457 | Protein folding | HSPA8/HSPA5/HSP90AB1/HSP90AA1/QSOX1/PPIA/ PDIA3/HSPA1A | 5.2E-07 |
3 | GO:0071560 | Cellular response to transforming growth factor beta stimulus | DKK3/COL3A1/COL1A1/ HSPA5/HSP90AB1/HSPA1A/EMILIN1 | 0.2E-4 |
4 | GO:0071559 | Response to transforming growth factor beta | DKK3/COL3A1/COL1A1/ HSPA5/HSP90AB1/HSPA1A/EMILIN1 | 0.2E-4 |
5 | GO:0007179 | Transforming growth factor beta receptor signalling pathway | DKK3/COL3A1/HSPA5/ HSP90AB1/HSPA1A/ EMILIN1 | 0.5E-4 |
6 | GO:0017015 | Regulation of transforming growth factor beta receptor signalling pathway | DKK3/HSPA5/HSP90AB1/ HSPA1A/EMILIN1 | 0.9E-4 |
7 | GO:1,903,844 | Regulation of cellular response to transforming growth factor beta stimulus | DKK3/HSPA5/HSP90AB1/ HSPA1A/EMILIN1 | 0.9E-4 |
8 | GO:0006757 | ATP generation from ADP | GAPDH/PKM/ENO1/ ALDOA | 0.3E-3 |
9 | GO:0032388 | Positive regulation of intracellular transport | MSN/YWHAE/HSP90AB1/ CD81/ANXA2 | 0.4E-3 |
10 | GO:0035967 | Cellular response to topologically incorrect protein | HSPA8/VCP/HSPA5/ HSPA1A | 0.4E-3 |