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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Multiple treatments with human embryonic stem cell-derived mesenchymal progenitor cells preserved the fertility and ovarian function of perimenopausal mice undergoing natural aging

Fig. 2

Effect of human embryonic stem cell-derived mesenchymal progenitor cells (hESC-MPCs) on the estrous cycles in perimenopausal mice. (A) Schematic illustrations of the experimental procedures used to evaluate the therapeutic effects of hESC-MPCs on reproductive aging in perimenopausal mice. (B) Representative images from hematoxylin-eosin (HE)-stained samples from vaginal lavage at each phase of the estrous cycle in C57BL/6 mice. (C) Staged estrus cycles of individual middle-aged control (14-month-old mice, upper) and hESC-MPC-multiple introduced mice (lower) (Pro, proestrus; Est, estrus; Met, metestrus; Di, diestrus). (D) Examples of regular estrous cycles within 2 weeks. (E) Estrus cycles were more regular in the hESC-MPCs group than in the control group as revealed by continuous vaginal smear continuous detection. *, significantly different (p < 0.05) (total n = 21 in the CON group; total n = 27 in the hESC-MPCs group). (total n = 20 in the CON group; total n = 21 in the hESC-MPCs group)

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Stem Cell Research & Therapy

ISSN: 1757-6512