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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Pyrroloquinoline quinone promotes human mesenchymal stem cell-derived mitochondria to improve premature ovarian insufficiency in mice through the SIRT1/ATM/p53 pathway

Fig. 1

Synergistic improvement of ovarian function in mice with POI by MSC-Mito and PQQ. (A) Changes in the body weight of mice in each group. (B) Ovarian diameter and morphology of the mice in each group. (C) Ovarian organ index of the mice in each group. (D) Proportion of abnormal oestrous cycles in the mice in each group. (E) Histological staining of ovarian tissue sections using HE. Red arrows indicate mature follicles. (F) Count of follicles at different stages and atretic follicles. (G) IHC assessment of FSHR receptor levels in granulosa cells of the ovaries from different groups of mice. (H-J) ELISA analysis of serum levels of AMH, E2, and FSH hormones in various groups of mice. (K-L) Measurement of SOD and MDA levels in ovarian tissues of different groups of mice. (M) Measurement of ATP content in ovarian tissues from different groups of mice. Scale bar: 50 μm. Values are the means ± SEMs. *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512