Fig. 7

haMSC-EVs alleviated pulmonary edema and inflammation in an LPS-induced ALI/ARDS rat model. A At 24 h, the haMSC-EVs reduced the left lung wet weight and left lung coefficient. B haMSC-EVs reduced the serum ALB and total protein levels in BALF at 24 h. C Inflammatory cell count in BALF at 24 h. D Serum levels of IL-1β, IL-6 and TNF-α decreased 4 h after administration. The serum levels of IL-1β, IL-6 and TNF-α were below the detection limits 24 h after administration. * and ** indicate significant differences compared with the Control group (*, P ≤ 0.05; **, P ≤ 0.01). # and ## indicate significant differences compared with the LPS + Placebo group (#, P ≤ 0.05; ##, P ≤ 0.01)