Fig. 2

Design, monitoring and terminal heart weight analysis of mouse diabetes model experiments (A-B). Summaries of experimental groups and time points for two mouse diabetes model experiments involving i.v. injections of saline or hUC-MSCs at earlier (A) and later (B) time-points following induction of diabetes. C-D. Graphs of baseline (before) and 2-weekly fasting blood glucose concentrations (in mmol/L) of three groups of mice each from experiments of 10 weeks (C) and 18 weeks (D) duration. E-F. Graphs of baseline (before) and 2-weekly body weights (in g) in the same experimental groups. G-H. Graphs of heart weights (G, in mg) and heart-body weight ratios (H, in mg/g) at the end-points of experiments of 10 weeks and 18 weeks duration n = 6 per group for all experiments. Results presented as mean ± SD. Statistical analysis was performed by 2-way Analysis of Variance (ANOVA) with adjustment for multiple comparisons. *:P < 0.05; **:P < 0.01; ***:P < 0.001; ****:P < 0.0001. Abbreviations: Non-DM = non-diabetic group; DM = diabetes mellitus with injection of saline; DM + MSC = diabetes mellitus with injection of hUC-MSCs, i.p.– intra-peritoneal, i.v. = intravenous