Table 1 Summary of results of cardiac functional indices from echocardiography of three groups of mice each from experiments of 10 weeks and 18 weeks duration

Heart Rate(bpm)

10 wks

501.6 ± 44.3

380.6 ± 50.4 *

389.3 ± 44.4 *

18 wks

515.7 ± 47.1

375.8 ± 55.8 *

382.6 ± 66 *

LVIDd(mm)

10 wks

3.6 ± 0.4

4.0 ± 0.2 *

3.6 ± 0.3

18 wks

3.7 ± 0.3

4.1 ± 0.4 *

3.6 ± 0.2 #

LVIDs(mm)

10 wks

2.7 ± 0.3

3.2 ± 0.3 *

2.6 ± 0.3 #

18 wks

2.6 ± 0.3

3.2 ± 0.4 *

2.6 ± 0.4

SV(µL)

10 wks

40.1 ± 4.4

30.9 ± 1.9 *

36.2 ± 2.8 *#

18 wks

39.4 ± 5.5

29.4 ± 2 *

35 ± 3.4 *

CO(mL/min)

10 wks

19.8 ± 2.2

13.7 ± 3.1 *

14.4 ± 2.9 *

18 wks

20.2 ± 2.7

12.5 ± 1.4 *

14 ± 2.8 *

LVAWd(mm)

10 wks

0.9 ± 0.1

0.7 ± 0.1 *

0.7 ± 0.1 *

18 wks

0.9 ± 0.1

0.8 ± 0.1

0.7 ± 0.1 *

LVAWs(mm)

10 wks

1.3 ± 0.1

1 ± 0.1 *

1 ± 0.1 *

18 wks

1.4 ± 0.1

1.1 ± 0.1 *

1 ± 0.1 *

LVPWd(mm)

10 wks

0.8 ± 0.1

0.7 ± 0.2

0.7 ± 0.1

18 wks

0.8 ± 0.1

0.7 ± 0.1

0.7 ± 0.1

LVPWs(mm)

10 wks

1.2 ± 0.1

1 ± 0.1 *

1 ± 0.1 *

18 wks

1.2 ± 0.1

1 ± 0.1 *

1 ± 0.1 *

LVW(mg)

10 wks

84.7 ± 7.4

67.1 ± 8.2 *

66.9 ± 5.8 *

18 wks

93.5 ± 8.5

76.6 ± 5 *

70.4 ± 10 *#