Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Simple modeling of familial Alzheimer’s disease using human pluripotent stem cell-derived cerebral organoid technology

Fig. 4

Formation of neurofibrillary tangle (NFT)-like structures and cellular apoptosis in an Alzheimer’s disease (AD) cerebral organoid (CO) model. (a) Representative images showing the NFT-like structures detected using Bielschowsky’s silver staining in the CmC and CAP COs treated with or without β-secretase inhibitor (BSI) and compound E (CE). Scale bar = 100 μm. (b) Representative immunohistochemistry images showing the cleaved caspase-3 (cCASP3) in the CmC and CAP COs treated with or without BSI or CE

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512