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Table 2 Effects of secretome on infiltration of cells after 5 days following renal I/R injury

From: Subcutaneous injection of adipose stromal cell-secretome improves renal function and reduces inflammation in established acute kidney injury

 

Sham

Vehicle

ASC-CS

Total mononuclear cells

3.8 ± 0.7 × 106

7.2 ± 1.2 × 106

3.7 ± 0.6 × 106

CD8 + 

3.0 ± 0.3 × 104

6.6 ± 0.2 × 105*

2.9 ± 0.9 × 105

CD8 + IL17 + 

6.2 ± 0.8 × 102

1.9 ± 0.4 × 103

2.1 ± 0.8 × 103

CD4 + Foxp3 + 

1.1 ± 0.2 × 104

2.3 ± 0.3 × 104*

1.6 ± 0.3 × 104

Foxp3 (%)

0.4 ± 0.1

1.5 ± 0.2

2.1 ± 0.7 †

  1. Values are expressed in mean ± SEM and derived from rats in the severe injury group (PCr ≥ 3.0 mg/dl). Inflammatory cell types are expressed per gram of kidney weight. *indicates P < 0.05 Sham vs Vehicle, and † indicates P < 0.01 Sham vs ASC-CS by Tukey’s multiple comparison test
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Stem Cell Research & Therapy

ISSN: 1757-6512