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Figure 8 | Stem Cell Research & Therapy

Figure 8

From: Increased heme-oxygenase 1 expression in mesenchymal stem cell-derived adipocytes decreases differentiation and lipid accumulation via upregulation of the canonical Wnt signaling cascade

Figure 8

Proposed mechanism demonstrating the interplay of heme oxygenase 1 (HO-1) and the Wnt canonical pathway in the modulation of adipogenesis in mesenchymal stem cells (MSC)-derived adipocytes. HO-1 suppresses adipocyte differentiation by increasing expression of key regulators including Wnt10b, p-glycogen synthase kinase (GSK), β-catenin and Sonic hedgehog (shh) and decreasing expression of adipogenic transcription factors CCAAT/enhancer binding protein a (CEBP)α, peroxisome proliferator-activated receptor (PPAR)γ and fatty-acid-binding protein (aP2). These effects led to decrease in lipid accumulation and increase of pre-adipocytes and healthy adipocytes that produce cytoprotective adipokines, such as adiponectin.

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Stem Cell Research & Therapy

ISSN: 1757-6512