Figure 2

Schematic representations of induction systems and criteria for successful hematopoietic development. Both mouse and human embryonic stem (ES)/induced pluripotent stem (iPS) cells can be differentiated into hematopoietic cells (HCs) from mesodermal cells with three approaches: embryoid body formation, feeder cell co-culture and extracellular matrix-coated culture. Hematopoietic stem cells and differentiated HCs must be tested and screened both in vitro and in vivo before being applied to patients.