Figure 4

Lung injury and inflammation in lipopolysaccharide-induced acute respiratory distress syndrome . Representative photomicrographs (×200 magnification) of lung tissue stained with hematoxylin and eosin (A), total and differential cell count in alveolar septa (B), and levels of interleukin (IL)-1β, IL-6 and IL-10 and chemokines keratinocyte-derived chemokine (KC or CXCL1) and monocyte chemotactic protein-1 (MCP-1 or CCL2) mRNA (C) and protein expressions (D) in lung tissue. Values expressed as mean ± standard deviation of six animals (B) and of four to six animals (C, D) per group. *Significantly different from corresponding control group (C) (P <0.05). ^#ARDS-BMDMC vs. ARDS-SAL (P <0.05). ARDS, acute respiratory distress syndrome; BMDMC, bone marrow-derived mononuclear cell; SAL, saline.