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Figure 7 | Stem Cell Research & Therapy

Figure 7

From: Glutathione S-transferase Mu 2-transduced mesenchymal stem cells ameliorated anti-glomerular basement membrane antibody-induced glomerulonephritis by inhibiting oxidation and inflammation

Figure 7

Human glutathione S-transferase Mu 2 mesenchymal stem cells (hGSTM2-MSCs) inhibited renal cell apoptosis in anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM-GN) mice. Terminal dUTP nick-end labeling (TUNEL) staining using DeadEnd™ Colorimetric Apoptosis Detection System to show apoptotic cells in renal sections of 129/svj with anti-GBM-GN injected with (A) pCDH-MSCs (vector control) or (B) hGSTM2-MSCs. Cells with brown nuclei are apoptotic cells (indicated by arrow). (C) Quantitative analysis of apoptotic cells expressed as a percentage of total cell number. Images were representative of sections from at least five mice in each study group (original magnification ×400, scale bars = 50 μm).

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Stem Cell Research & Therapy

ISSN: 1757-6512