Table 1 Summary of ongoing clinical investigations involving bone marrow-derived mesenchymal stem cells applied to long bone fracture
Identifier | Location | Date submitted | Treatment | Number of patients |
|---|---|---|---|---|
NCT00250302 | Israel | Nov. 2005 | Autologous bone marrow-derived MSCs loaded onto a carrier and implanted into the fractured tibia | 24 |
NCT00512434 | France | Aug. 2007 | Concentrated autologous bone marrow delivered percutaneously to a tibial non-union | 85 |
NCT00557635 | France | Nov. 2007 | Osseous matrix with concentrated autologous marrow to treat tibial or femoral pseudo-arthrosis | 50 |
NCT01206179 | Iran | Sept. 2010 | Percutaneous MSC injection into the fracture callus of a long bone | 6 |
NCT01429012 | Belgium | Sept. 2011 | Autologous bone marrow-derived MSCs percutaneously administered to atrophic non-union | 40 |
NCT01435434 | Israel | Sept. 2011 | Tibia or femur non-union treated with DBM and autologous ‘buffy coat’ progenitors | Not Provided |
NCT01581892 | Spain | April 2012 | Ficoll isolated autologous MSCs mixed with osteogenic matrix and implanted at the site of long bone non-union | 30 |
NCT01626625 | Indonesia | June 2012 | Expanded bone marrow-derived MSCs applied to non-unions with HA as compared with autograft | 10 |
NCT01725698 | Indonesia | Nov. 2012 | Osteoconductive matrix with MSCs and BMP-2 to treat critical-sized bone defects | 5 |
NCT01788059 | Iran | Jan. 2013 | Autologous bone marrow MSCs isolated by Ficoll gradient, then implanted into tibial non-unions | 18 |
NCT01842477 | France | April 2013 | Autologous bone marrow cells expanded and implanted with scaffold at the site of non-union in a femur or tibia | 30 |