Table 2 Histologic scoring

Cell shape

1.0 (0.9 to 1.3)

2.0 (1.8 to 2.3)*

<0.0001

Cell density

1.0 (2.0 to 2.0)

2.75 (2.3 to 3.0)*

0.0002

Free hemorrhage

1.0 (0.9 to 1.7)

1.75 (1.1 to 2.4)

0.1

Neo-vascularization

2.0 (1.4 to 2.2)

2.0 (1.2 to 2.3)

0.7

Perivascular cuffing

1.5 (1.1 to 2.0)

1.0 (0.83 to 1.4)

0.1

Collagen linearity

2.0 (1.3 to 2.1)

2.75 (2.4 to 3.0)*

<0.0001

Collagen uniformity

2.0 (1.4 to 2.1)

3.0 (2.8 to 3.1)*

<0.0001

Polarized crimping

1.5 (1.2 to 2.1)

3.0 (2.7 to 3.3)*

<0.0001

Epitenon thickening

2.3 (2.0 to 2.6)

3.0 (2.6 to 3.5)*

0.0009

Cumulative Score

15.4 (12.6 to 17.8)

20.8 (19.0 to 23.0)*

<0.0001