Table 3 Phenotypes for loss of function of Oct4-associated transcriptional regulators
From: In silico tandem affinity purification refines an Oct4 interaction list
Protein | Biological process | Loss-of-function phenotype |
|---|---|---|
Psip1 | Transcription factor activity (PANTHER) | Perinatal death (survivors show reduced fertility) |
Tardbp | Transcription factor activity (PANTHER) | Embryonic lethality before somite formation with impaired inner cell mass proliferation |
Fus | Positive regulation of transcription, DNA-dependent (DAVID), transcription factor activity (PANTHER) | High neonatal mortality, and male sterility associated with lack of chromosomal pairing |
Top2a | Positive regulation of transcription, DNA-dependent (DAVID) | Nil |
Fubp3 | Positive regulation of transcription, DNA-dependent (DAVID) | Nil |