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Figure 4 | Stem Cell Research & Therapy

Figure 4

From: MicroRNA profiling reveals age-dependent differential expression of nuclear factor κB and mitogen-activated protein kinase in adipose and bone marrow-derived human mesenchymal stem cells

Figure 4

Canonic pathway of predicted gene expression influenced by miRNA in adipose stem cells (ASCs) and bone marrow stem cells (BMSCs). Canonic pathways derived from predicted putative targets of miRNA action on gene expression by using Ingenuity Pathways Assessment (IPA) analysis of MSCs from old versus young donors. (a) Downregulated miRNA in BMSCs from old compared with young donors. (b) Upregulated miRNA in BMSCs from old, compared with young donors. (c) Downregulated miRNA in ASCs from old, compared with young donors. (d) Upregulated miRNA in ASCs from old, compared with young donors. Yellow line represents P-value cutoff (P < 0.05), and yellow dots represent ratio of projected involvement of targets to actual inputted involvement. Height of bars is determined by projected involvement of particular pathway.

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Stem Cell Research & Therapy

ISSN: 1757-6512