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  1. Research

    Regeneration of full-thickness skin defects by differentiated adipose-derived stem cells into fibroblast-like cells by fibroblast-conditioned medium

    Fibroblasts are ubiquitous cells in the human body and are absolutely necessary for wound healing such as for injured skin. This role of fibroblasts was the reason why we aimed to differentiate human adipose-d...

    Woojune Hur, Hoon Young Lee, Hye Sook Min, Maierdanjiang Wufuer, Chang-won Lee, Ji An Hur, Sang Hyon Kim, Byeung Kyu Kim and Tae Hyun Choi

    Stem Cell Research & Therapy 2017 8:92

    Published on: 20 April 2017

  2. Research

    Autophagy mediates the beneficial effect of hypoxic preconditioning on bone marrow mesenchymal stem cells for the therapy of myocardial infarction

    Stem cell therapy has emerged as a promising therapeutic strategy for myocardial infarction (MI). However, the poor viability of transplanted stem cells hampers their therapeutic efficacy. Hypoxic precondition...

    Zheng Zhang, Chao Yang, Mingzhi Shen, Ming Yang, Zhitao Jin, Liping Ding, Wei Jiang, Junke Yang, Haixu Chen, Feng Cao and Taohong Hu

    Stem Cell Research & Therapy 2017 8:89

    Published on: 18 April 2017

  3. Research

    Autologous bone marrow-derived cell transplantation in decompensated alcoholic liver disease: what is the impact on liver histology and gene expression patterns?

    Liver stem cell therapy (SCT) has been suggested as a promising means to improve liver regeneration in advanced liver disease. However, data from trials are heterogeneous, with no systematic histological evalu...

    Nicolas Lanthier, Nathalie Lin-Marq, Laura Rubbia-Brandt, Sophie Clément, Nicolas Goossens and Laurent Spahr

    Stem Cell Research & Therapy 2017 8:88

    Published on: 18 April 2017

  4. Research

    Isolation and characterization of equine native MSC populations

    In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a ...

    Cristina L. Esteves, Tara A. Sheldrake, Simone P. Mesquita, Juan J. Pesántez, Timothy Menghini, Lucy Dawson, Bruno Péault and F. Xavier Donadeu

    Stem Cell Research & Therapy 2017 8:80

    Published on: 18 April 2017

  5. Research

    CK2.1, a bone morphogenetic protein receptor type Ia mimetic peptide, repairs cartilage in mice with destabilized medial meniscus

    Osteoarthritis (OA) of the knee involves degeneration of articular cartilage of the diarthrodial joints. Current treatment options temporarily relieve the joint pain but do not restore the lost cartilage. We r...

    Hemanth Akkiraju, Padma Pradeepa Srinivasan, Xian Xu, Xinqiao Jia, Catherine B. Kirn Safran and Anja Nohe

    Stem Cell Research & Therapy 2017 8:82

    Published on: 18 April 2017

  6. Research

    Umbilical cord-derived mesenchymal stem cells on scaffolds facilitate collagen degradation via upregulation of MMP-9 in rat uterine scars

    Severe injuries of the uterus may trigger uterine scar formation, ultimately leading to infertility or obstetrical complications. To date, few methods have adequately solved the problem of collagen deposition ...

    Lu Xu, Lijun Ding, Lei Wang, Yun Cao, Hui Zhu, Jingjie Lu, Xin’an Li, Tianran Song, Yali Hu and Jianwu Dai

    Stem Cell Research & Therapy 2017 8:84

    Published on: 18 April 2017

  7. Research

    Distribution pattern following systemic mesenchymal stem cell injection depends on the age of the recipient and neuronal health

    Mesenchymal stem cells (MSCs) show therapeutic efficacy in many different age-related degenerative diseases, including Alzheimer’s disease. Very little is currently known about whether or not aging impacts the...

    Claire Fabian, Yahaira Naaldijk, Christiane Leovsky, Adiv A. Johnson, Lukas Rudolph, Carsten Jaeger, Katrin Arnold and Alexandra Stolzing

    Stem Cell Research & Therapy 2017 8:85

    Published on: 18 April 2017

  8. Research

    Adult muscle-derived stem cells engraft and differentiate into insulin-expressing cells in pancreatic islets of diabetic mice

    Pancreatic beta cells are unique effectors in the control of glucose homeostasis and their deficiency results in impaired insulin production leading to severe diabetic diseases. Here, we investigated the poten...

    Violeta Mitutsova, Wendy Wai Yeng Yeo, Romain Davaze, Celine Franckhauser, El-Habib Hani, Syahril Abdullah, Patrice Mollard, Marie Schaeffer, Anne Fernandez and Ned J. C. Lamb

    Stem Cell Research & Therapy 2017 8:86

    Published on: 18 April 2017

  9. Research

    The neuroprotective effects of human bone marrow mesenchymal stem cells are dose-dependent in TNBS colitis

    The incidence of inflammatory bowel diseases (IBD) is increasing worldwide with patients experiencing severe impacts on their quality of life. It is well accepted that intestinal inflammation associates with e...

    Ainsley M. Robinson, Ahmed A. Rahman, Sarah Miller, Rhian Stavely, Samy Sakkal and Kulmira Nurgali

    Stem Cell Research & Therapy 2017 8:87

    Published on: 18 April 2017

  10. Research

    Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro

    Inflammation is a key contributor to central nervous system (CNS) injury such as stroke, and is a major target for therapeutic intervention. Effective treatments for CNS injuries are limited and applicable to ...

    Elena Redondo-Castro, Catriona Cunningham, Jonjo Miller, Licia Martuscelli, Sarah Aoulad-Ali, Nancy J. Rothwell, Cay M. Kielty, Stuart M. Allan and Emmanuel Pinteaux

    Stem Cell Research & Therapy 2017 8:79

    Published on: 17 April 2017

  11. Research

    Engagement of cellular prion protein with the co-chaperone Hsp70/90 organizing protein regulates the proliferation of glioblastoma stem-like cells

    Glioblastoma (GBM), a highly aggressive brain tumor, contains a subpopulation of glioblastoma stem-like cells (GSCs) that play roles in tumor maintenance, invasion, and therapeutic resistance. GSCs are therefo...

    Rebeca Piatniczka Iglesia, Mariana Brandão Prado, Lilian Cruz, Vilma Regina Martins, Tiago Góss Santos and Marilene Hohmuth Lopes

    Stem Cell Research & Therapy 2017 8:76

    Published on: 17 April 2017

  12. Research

    Hepatic population derived from human pluripotent stem cells is effectively increased by selective removal of undifferentiated stem cells using YM155

    Pluripotent stem cells (PSCs) such as embryonic stem cells and induced pluripotent stem cells are promising target cells for cell regenerative medicine together with recently advanced technology of in-vitro di...

    Seok-Jin Kang, Young-Il Park, So-Ryeon Hwang, Hee Yi, Nga Tham, Hyun-Ok Ku, Jae-Young Song and Hwan-Goo Kang

    Stem Cell Research & Therapy 2017 8:78

    Published on: 17 April 2017

  13. Research

    Pre-incubation with hucMSC-exosomes prevents cisplatin-induced nephrotoxicity by activating autophagy

    The administration of cisplatin is limited due to its nephrotoxic side effects, and prevention of this nephrotoxicity of cisplatin is difficult. Mesenchymal stem cell (MSC)-derived exosomes have been implicate...

    Bingying Wang, Haoyuan Jia, Bin Zhang, Juanjuan Wang, Cheng Ji, Xueming Zhu, Yongmin Yan, Lei Yin, Jing Yu, Hui Qian and Wenrong Xu

    Stem Cell Research & Therapy 2017 8:75

    Published on: 8 April 2017

  14. Research

    Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function

    Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not...

    Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra and Timothy Q. Duong

    Stem Cell Research & Therapy 2017 8:74

    Published on: 22 March 2017

  15. Research

    DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

    Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair syste...

    Pavel Simara, Lenka Tesarova, Daniela Rehakova, Pavel Matula, Stanislav Stejskal, Ales Hampl and Irena Koutna

    Stem Cell Research & Therapy 2017 8:73

    Published on: 21 March 2017

  16. Research

    Compared to the amniotic membrane, Wharton’s jelly may be a more suitable source of mesenchymal stem cells for cardiovascular tissue engineering and clinical regeneration

    The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as a valu...

    Lei Pu, Mingyao Meng, Jian Wu, Jing Zhang, Zongliu Hou, Hui Gao, Hui Xu, Boyu Liu, Weiwei Tang, Lihong Jiang and Yaxiong Li

    Stem Cell Research & Therapy 2017 8:72

    Published on: 21 March 2017

  17. Research

    Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure

    Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms. Heme oxygenase (HO) 1, a rate-lim...

    Zhi-heng Zhang, Wei Zhu, Hao-zhen Ren, Xin Zhao, Shuai Wang, Hu-cheng Ma and Xiao-lei Shi

    Stem Cell Research & Therapy 2017 8:70

    Published on: 20 March 2017

  18. Research

    Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells

    Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, ...

    Lorenzo Nevi, Guido Carpino, Daniele Costantini, Vincenzo Cardinale, Olga Riccioni, Sabina Di Matteo, Fabio Melandro, Pasquale Bartolomeo Berloco, Lola Reid, Eugenio Gaudio and Domenico Alvaro

    Stem Cell Research & Therapy 2017 8:68

    Published on: 20 March 2017

  19. Research

    Dysregulated systemic lymphocytes affect the balance of osteogenic/adipogenic differentiation of bone mesenchymal stem cells after local irradiation

    While it is known that irradiation can induce local and systemic bone loss over time, how focal irradiation induces systemic bone complications remains unclear. Immune cells are thought to be crucial to bone h...

    Xiaoya Xu, Ruixia Li, Yi Zhou, Qiong Zou, Qiaoling Ding, Jinfeng Wang, Weifang Jin, Guoqiang Hua and Jianjun Gao

    Stem Cell Research & Therapy 2017 8:71

    Published on: 20 March 2017

  20. Research

    Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

    Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine saf...

    Kaitlin C. Clark, Fernando A. Fierro, Emily Mills Ko, Naomi J. Walker, Boaz Arzi, Clifford G. Tepper, Heather Dahlenburg, Andrew Cicchetto, Amir Kol, Lyndsey Marsh, William J. Murphy, Nasim Fazel and Dori L. Borjesson

    Stem Cell Research & Therapy 2017 8:69

    Published on: 20 March 2017

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