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  1. Research

    Intraarterial transplantation of human umbilical cord blood mononuclear cells in hyperacute stroke improves vascular function

    Human umbilical cord blood (hUCB) cell therapy is a promising treatment for ischemic stroke. The effects of hyperacute stem cell transplantation on cerebrovascular function in ischemic stroke are, however, not...

    Lei Huang, Yichu Liu, Jianfei Lu, Bianca Cerqueira, Vivek Misra and Timothy Q. Duong

    Stem Cell Research & Therapy 2017 8:74

    Published on: 22 March 2017

  2. Research

    DNA double-strand breaks in human induced pluripotent stem cell reprogramming and long-term in vitro culturing

    Human induced pluripotent stem cells (hiPSCs) play roles in both disease modelling and regenerative medicine. It is critical that the genomic integrity of the cells remains intact and that the DNA repair syste...

    Pavel Simara, Lenka Tesarova, Daniela Rehakova, Pavel Matula, Stanislav Stejskal, Ales Hampl and Irena Koutna

    Stem Cell Research & Therapy 2017 8:73

    Published on: 21 March 2017

  3. Research

    Compared to the amniotic membrane, Wharton’s jelly may be a more suitable source of mesenchymal stem cells for cardiovascular tissue engineering and clinical regeneration

    The success of developing cardiovascular tissue engineering (CTE) grafts greatly needs a readily available cell substitute for endothelial and interstitial cells. Perinatal annexes have been proposed as a valu...

    Lei Pu, Mingyao Meng, Jian Wu, Jing Zhang, Zongliu Hou, Hui Gao, Hui Xu, Boyu Liu, Weiwei Tang, Lihong Jiang and Yaxiong Li

    Stem Cell Research & Therapy 2017 8:72

    Published on: 21 March 2017

  4. Research

    Mesenchymal stem cells increase expression of heme oxygenase-1 leading to anti-inflammatory activity in treatment of acute liver failure

    Mesenchymal stem cells (MSCs) have been studied for the treatment of acute liver failure (ALF) for several years. MSCs may exert their effect via complex paracrine mechanisms. Heme oxygenase (HO) 1, a rate-lim...

    Zhi-heng Zhang, Wei Zhu, Hao-zhen Ren, Xin Zhao, Shuai Wang, Hu-cheng Ma and Xiao-lei Shi

    Stem Cell Research & Therapy 2017 8:70

    Published on: 20 March 2017

  5. Research

    Hyaluronan coating improves liver engraftment of transplanted human biliary tree stem/progenitor cells

    Cell therapy of liver diseases with human biliary tree stem cells (hBTSCs) is biased by low engraftment efficiency. Coating the hBTSCs with hyaluronans (HAs), the primary constituents of all stem cell niches, ...

    Lorenzo Nevi, Guido Carpino, Daniele Costantini, Vincenzo Cardinale, Olga Riccioni, Sabina Di Matteo, Fabio Melandro, Pasquale Bartolomeo Berloco, Lola Reid, Eugenio Gaudio and Domenico Alvaro

    Stem Cell Research & Therapy 2017 8:68

    Published on: 20 March 2017

  6. Research

    Dysregulated systemic lymphocytes affect the balance of osteogenic/adipogenic differentiation of bone mesenchymal stem cells after local irradiation

    While it is known that irradiation can induce local and systemic bone loss over time, how focal irradiation induces systemic bone complications remains unclear. Immune cells are thought to be crucial to bone h...

    Xiaoya Xu, Ruixia Li, Yi Zhou, Qiong Zou, Qiaoling Ding, Jinfeng Wang, Weifang Jin, Guoqiang Hua and Jianjun Gao

    Stem Cell Research & Therapy 2017 8:71

    Published on: 20 March 2017

  7. Research

    Human and feline adipose-derived mesenchymal stem cells have comparable phenotype, immunomodulatory functions, and transcriptome

    Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine saf...

    Kaitlin C. Clark, Fernando A. Fierro, Emily Mills Ko, Naomi J. Walker, Boaz Arzi, Clifford G. Tepper, Heather Dahlenburg, Andrew Cicchetto, Amir Kol, Lyndsey Marsh, William J. Murphy, Nasim Fazel and Dori L. Borjesson

    Stem Cell Research & Therapy 2017 8:69

    Published on: 20 March 2017

  8. Research

    Cytokine-free directed differentiation of human pluripotent stem cells efficiently produces hemogenic endothelium with lymphoid potential

    The robust generation of human hematopoietic progenitor cells from induced or embryonic pluripotent stem cells would be beneficial for multiple areas of research, including mechanistic studies of hematopoiesis...

    Yekaterina Galat, Svetlana Dambaeva, Irina Elcheva, Aaruni Khanolkar, Kenneth Beaman, Philip M. Iannaccone and Vasiliy Galat

    Stem Cell Research & Therapy 2017 8:67

    Published on: 17 March 2017

  9. Research

    Influence of temperature fluctuations during cryopreservation on vital parameters, differentiation potential, and transgene expression of placental multipotent stromal cells

    Successful implementation of rapidly advancing regenerative medicine approaches has led to high demand for readily available cellular suspensions. In particular, multipotent stromal cells (MSCs) of placental o...

    Denys Pogozhykh, Olena Pogozhykh, Volodymyr Prokopyuk, Larisa Kuleshova, Anatoliy Goltsev, Rainer Blasczyk and Thomas Mueller

    Stem Cell Research & Therapy 2017 8:66

    Published on: 11 March 2017

  10. Research

    Impaired osteogenesis of T1DM bone marrow-derived stromal cells and periosteum-derived cells and their differential in-vitro responses to growth factor rescue

    Poor bone quality, increased fracture risks, and impaired bone healing are orthopedic comorbidities of type 1 diabetes (T1DM). Standard osteogenic growth factor treatments are inadequate in fully rescuing reta...

    Tera M. Filion, Jordan D. Skelly, Henry Huang, Dale L. Greiner, David C. Ayers and Jie Song

    Stem Cell Research & Therapy 2017 8:65

    Published on: 11 March 2017

  11. Research

    Short-course rapamycin treatment enables engraftment of immunogenic gene-engineered bone marrow under low-dose irradiation to permit long-term immunological tolerance

    Application of genetically modified hematopoietic stem cells is increasingly mooted as a clinically relevant approach to protein replacement therapy, immune tolerance induction or conditions where both outcome...

    Kunal H. Bhatt, Rajeev Rudraraju, Jeremy F. Brooks, Ji-Won Jung, Ryan Galea, James W. Wells and Raymond J. Steptoe

    Stem Cell Research & Therapy 2017 8:57

    Published on: 9 March 2017

  12. Research

    CD117+CD44+ Stem T Cells Develop in the Thymus and Potently Suppress T-cell Proliferation by Modulating the CTLA-4 Pathway

    CD117 is expressed on double-negative (DN; CD4CD8) cells (Nat Rev Immunol 14:529–545; 2014), but whether it is expressed in other stages and its subsequent functions are unclear. We used an improved method of f...

    Yang Wei, Zhansheng Hu, Wen Gu, Gang Liu, Bingyin Shi, Enqi Liu and Tie Liu

    Stem Cell Research & Therapy 2017 8:56

    Published on: 9 March 2017

  13. Research

    Comparison of exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells and synovial membrane-derived mesenchymal stem cells for the treatment of osteoarthritis

    Osteoarthritis (OA) is the most common joint disease worldwide. In the past decade, mesenchymal stem cells (MSCs) have been used widely for the treatment of OA. A potential mechanism of MSC-based therapies has...

    Yu Zhu, Yuchen Wang, Bizeng Zhao, Xin Niu, Bin Hu, Qing Li, Juntao Zhang, Jian Ding, Yunfeng Chen and Yang Wang

    Stem Cell Research & Therapy 2017 8:64

    Published on: 9 March 2017

  14. Research

    Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study

    Experiments have previously demonstrated the therapeutic potential of mobilized dental pulp stem cells (MDPSCs) for complete pulp regeneration. The aim of the present pilot clinical study is to assess the safe...

    Misako Nakashima, Koichiro Iohara, Masashi Murakami, Hiroshi Nakamura, Yayoi Sato, Yoshiko Ariji and Kenji Matsushita

    Stem Cell Research & Therapy 2017 8:61

    Published on: 9 March 2017

  15. Research

    Stroke alters behavior of human skin-derived neural progenitors after transplantation adjacent to neurogenic area in rat brain

    Intracerebral transplantation of human induced pluripotent stem cells (iPSCs) can ameliorate behavioral deficits in animal models of stroke. How the ischemic lesion affects the survival of the transplanted cel...

    Carlos de la Rosa-Prieto, Cecilia Laterza, Ana Gonzalez-Ramos, Somsak Wattananit, Ruimin Ge, Olle Lindvall, Daniel Tornero and Zaal Kokaia

    Stem Cell Research & Therapy 2017 8:59

    Published on: 9 March 2017

  16. Research

    Allogenic adipose-derived stem cell therapy overcomes ischemia-induced microvessel rarefaction in the myocardium: systems biology study

    Myocardial microvascular loss after myocardial infarction (MI) remains a therapeutic challenge. Autologous stem cell therapy was considered as an alternative; however, it has shown modest benefits due to the i...

    Gemma Vilahur, Blanca Oñate, Judit Cubedo, Maria Teresa Béjar, Gemma Arderiu, Esther Peña, Laura Casaní, Manuel Gutiérrez, Antoni Capdevila, Guillem Pons-Lladó, Francesc Carreras, Alberto Hidalgo and Lina Badimon

    Stem Cell Research & Therapy 2017 8:52

    Published on: 9 March 2017

  17. Research

    Urethral reconstruction with autologous urine-derived stem cells seeded in three-dimensional porous small intestinal submucosa in a rabbit model

    Urethral reconstruction is one of the great surgical challenges for urologists. A cell-based tissue-engineered urethra may be an alternative for patients who have complicated long strictures and need urethral ...

    Yang Liu, Wenjun Ma, Bo Liu, Yangcai Wang, Jiaqiang Chu, Geng Xiong, Lianju Shen, Chunlan Long, Tao Lin, Dawei He, Denis Butnaru, Lyundup Alexey, Yuanyuan Zhang, Deying Zhang and Guanghui Wei

    Stem Cell Research & Therapy 2017 8:63

    Published on: 9 March 2017

  18. Research

    Human mesenchymal stromal cells inhibit tumor growth in orthotopic glioblastoma xenografts

    Mesenchymal stem/stromal cells (MSCs) represent an attractive tool for cell-based cancer therapy mainly because of their ability to migrate to tumors and to release bioactive molecules. However, the impact of ...

    Simone Pacioni, Quintino Giorgio D’Alessandris, Stefano Giannetti, Liliana Morgante, Valentina Coccè, Arianna Bonomi, Mariachiara Buccarelli, Luisa Pascucci, Giulio Alessandri, Augusto Pessina, Lucia Ricci-Vitiani, Maria Laura Falchetti and Roberto Pallini

    Stem Cell Research & Therapy 2017 8:53

    Published on: 9 March 2017

  19. Review

    CRISPR-targeted genome editing of mesenchymal stem cell-derived therapies for type 1 diabetes: a path to clinical success?

    Due to their ease of isolation, differentiation capabilities, and immunomodulatory properties, the therapeutic potential of mesenchymal stem cells (MSCs) has been assessed in numerous pre-clinical and clinical...

    Dario Gerace, Rosetta Martiniello-Wilks, Najah Therese Nassif, Sara Lal, Raymond Steptoe and Ann Margaret Simpson

    Stem Cell Research & Therapy 2017 8:62

    Published on: 9 March 2017

  20. Research

    Sox9 transcriptionally regulates Wnt signaling in intestinal epithelial stem cells in hypomethylated crypts in the diabetic state

    Distinctive structures called crypts harbor intestinal epithelial stem cells (IESCs) which generate progenitor and terminally differentiated cells in the intestinal epithelium. Mammalian IESCs and their daught...

    Can-Ze Huang, Ji-Hao Xu, Wa Zhong, Zhong-Sheng Xia, Si-Yi Wang, Di Cheng, Jie-Yao Li, Ting-Feng Wu, Qi-Kui Chen and Tao Yu

    Stem Cell Research & Therapy 2017 8:60

    Published on: 9 March 2017

  21. Research

    Systemic administration of mesenchymal stem cells combined with parathyroid hormone therapy synergistically regenerates multiple rib fractures

    A devastating condition that leads to trauma-related morbidity, multiple rib fractures, remain a serious unmet clinical need. Systemic administration of mesenchymal stem cells (MSCs) has been shown to regenera...

    Doron Cohn Yakubovich, Dmitriy Sheyn, Maxim Bez, Yeshai Schary, Eran Yalon, Afeef Sirhan, May Amira, Alin Yaya, Sandra De Mel, Xiaoyu Da, Shiran Ben-David, Wafa Tawackoli, Eric J. Ley, Dan Gazit, Zulma Gazit and Gadi Pelled

    Stem Cell Research & Therapy 2017 8:51

    Published on: 9 March 2017

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