Figure 3
From: Ixmyelocel-T, an expanded multicellular therapy, contains a unique population of M2-like macrophages
Ixmyelocel-T macrophages express genes of alternatively activated macrophage phenotype. Quantitative real-time PCR gene expression analysis of alternatively activated macrophage markers within the ixmyelocel-T macrophages normalized to GAPDH (n ≥ 4). Relative expression of (A) CD206, (B) CD163, (C) SR-B1, (D) MerTK, (E) PPARγ, and (F) TGFβ in CD14+ ixmyelocel-T macrophages. Values are presented as mean ± SEM relative to control, *P <0.05 vs ixmyelocel-T,**P < 0.01 vs ixmyelocel-T, ***P < 0.001 vs ixmyelocel-T. GAPDH, glyceraldehyde 3-phosphate dehydrogenase; PPAR-γ, peroxisome proliferator-activated receptor gamma; TGFβ, transforming growth factor beta.