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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease tubulointerstitial fibrosis in unilateral ureteral obstruction

Figure 6

Anti-apoptotic effects of in vivo engrafted-MPs in UUO kidneys. Confocal laser microscopy confirms the engraftment of red CellTracker™ labeled MPs and TUNEL staining in UUO kidneys. High-power fields in which red CellTracker™ labeled MPs (white arrows) were present showed no apoptotic cells (TUNEL positive green nuclei, yellow arrows), compared to high-power fields without MPs (A). Quantitative analysis demonstrates the total number of TUNEL-positive nuclei in high-power fields with or without MPs. Results are expressed as the mean ± SE of six different experiments. The Kruskal-Wallis test was performed; * P <0.05 versus vehicle control (B). White bar represents 20 μm. MPs, microparticles; SE, standard error; TUNEL, terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling; UUO, unilateral uretal obstruction.

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Stem Cell Research & Therapy

ISSN: 1757-6512