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  1. Content type: Research

    Human induced pluripotent stem (iPS) cells have revolutionised research and spark hopes for future tissue replacement therapies. To obtain high cell numbers, iPS cells can be expanded indefinitely. However, as...

    Authors: David Brenière-Letuffe, Aya Domke-Shibamiya, Arne Hansen, Thomas Eschenhagen, Boris Fehse, Kristoffer Riecken and Justus Stenzig

    Citation: Stem Cell Research & Therapy 2018 9:165

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  2. Content type: Short report

    Generation of induced pluripotent stem cells (iPSCs) from human peripheral blood provides a convenient and low-invasive way to obtain patient-specific iPSCs. The episomal vector is one of the best approaches f...

    Authors: Haihui Gu, Xia Huang, Jing Xu, Lili Song, Shuping Liu, Xiao-bing Zhang, Weiping Yuan and Yanxin Li

    Citation: Stem Cell Research & Therapy 2018 9:163

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  3. Content type: Research

    The activation and expansion of bipotent liver progenitor cells (LPCs) are indispensable for liver regeneration after severe or chronic liver injury. However, the underlying molecular mechanisms regulating LPC...

    Authors: Yuting Gu, Weiting Wei, Yiji Cheng, Bing Wan, Xinyuan Ding, Hui Wang, Yanyun Zhang and Min Jin

    Citation: Stem Cell Research & Therapy 2018 9:164

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  4. Content type: Research

    One of the major obstacles facing stem cell therapy is the limited number of functional stem cells available after transplantation due to the harsh microenvironment surrounding the damaged tissue. The aim of t...

    Authors: Mianhuan Li, Yi Lv, Feng Chen, Xiaoyan Wang, Jiang Zhu, Hao Li and Jia Xiao

    Citation: Stem Cell Research & Therapy 2018 9:161

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  5. Content type: Research

    Osteoarthritis (OA) is a widespread arthritic disease and a primary cause of disability. Increasing evidence suggests that inflammation has a pivotal part in its pathogenesis. Interleukin-1β (IL-1β) is a prima...

    Authors: Bo Gao, Wenjie Gao, Zizhao Wu, Taifeng Zhou, Xianjian Qiu, Xudong Wang, Chengjie Lian, Yan Peng, Anjing Liang, Jincheng Qiu, Yuanxin Zhu, Caixia Xu, Yibing Li, Peiqiang Su and Dongsheng Huang

    Citation: Stem Cell Research & Therapy 2018 9:162

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  6. Content type: Research

    The physiological approach suggests that an environment associating mesenchymal stromal cells with low O2 concentration would be most favorable for the maintenance of hematopoietic stem/progenitor cells (HSPCs). ...

    Authors: Dewan Zhao, Lingjia Liu, Qiang Chen, Fangfang Wang, Qiuyang Li, Qiang Zeng, Jingcao Huang, Maowen Luo, Wenxian Li, Yuhuan Zheng and Ting Liu

    Citation: Stem Cell Research & Therapy 2018 9:158

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  7. Content type: Research

    Arterial calcification is associated with cardiovascular disease as a complication of advanced atherosclerosis and is a significant contributor to cardiovascular morbidity and mortality. Osteoblastic different...

    Authors: Shuangshuang Wang, Siwang Hu, Jian Wang, Yahui Liu, Ruochi Zhao, Maoqing Tong, Hanbin Cui, Nan Wu and Xiaomin Chen

    Citation: Stem Cell Research & Therapy 2018 9:160

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  8. Content type: Research

    The use of human pluripotent stem cell-derived retinal cells for cell therapy strategies and disease modelling relies on the ability to obtain healthy and organised retinal tissue in sufficient quantities. Gen...

    Authors: Patrick Ovando-Roche, Emma L. West, Matthew J. Branch, Robert D. Sampson, Milan Fernando, Peter Munro, Anastasios Georgiadis, Matteo Rizzi, Magdalena Kloc, Arifa Naeem, Joana Ribeiro, Alexander J. Smith, Anai Gonzalez-Cordero and Robin R. Ali

    Citation: Stem Cell Research & Therapy 2018 9:156

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  9. Content type: Research

    Mesenchymal stem cells (MSC) have gained credibility as a therapeutic tool partly due to their potential to secrete factors such as cytokines and chemokines. Recently, exosomes, which mediate intercellular com...

    Authors: Xiaochun Liu, Shiwei Wang, Suhui Wu, Qian Hao, Ying Li, Zhuodan Guo and Wenzhen Wang

    Citation: Stem Cell Research & Therapy 2018 9:159

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  10. Content type: Review

    Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a worldwide leading c...

    Authors: Austin C. Boese, Quan-Son Eric Le, Dylan Pham, Milton H. Hamblin and Jean-Pyo Lee

    Citation: Stem Cell Research & Therapy 2018 9:154

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  11. Content type: Research

    Efficacious bone substitute is essential for the treatment of a critical size bone defect. Currently, the bone substitutes commonly used in clinical practice lack osteogenic capacity and the therapeutic effica...

    Authors: Wenxiang Chu, Yaokai Gan, Yifu Zhuang, Xin Wang, Jie Zhao, Tingting Tang and Kerong Dai

    Citation: Stem Cell Research & Therapy 2018 9:157

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  12. Content type: Research

    Airway disease is a primary cause of morbidity and early mortality for patients with cystic fibrosis (CF). Cell transplantation therapy has proven successful for treating immune disorders and may have the pote...

    Authors: Nigel Farrow, Patricia Cmielewski, Martin Donnelley, Nathan Rout-Pitt, Yuben Moodley, Ivan Bertoncello and David Parsons

    Citation: Stem Cell Research & Therapy 2018 9:153

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  13. Content type: Research

    Bone marrow-derived mesenchymal stromal cell (MSC) therapy is a promising treatment for several degenerative ocular diseases; however, no reproducible method of monitoring these cells into the eye has been est...

    Authors: Carolina Assis P. Vilela, Lucas Eduardo B. Souza, Rubens C. Siqueira, Rodrigo T. Calado, Dimas T. Covas and Jayter S. Paula

    Citation: Stem Cell Research & Therapy 2018 9:155

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  14. Content type: Research

    Amyotrophic lateral sclerosis (ALS) is a motor neuron (MN) disease characterized by the loss of MNs in the central nervous system. As MNs die, patients progressively lose their ability to control voluntary mov...

    Authors: Michal Izrael, Shalom Guy Slutsky, Tamar Admoni, Louisa Cohen, Avital Granit, Arik Hasson, Joseph Itskovitz-Eldor, Lena Krush Paker, Graciela Kuperstein, Neta Lavon, Shiran Yehezkel Ionescu, Leonardo Javier Solmesky, Rachel Zaguri, Alina Zhuravlev, Ella Volman, Judith Chebath…

    Citation: Stem Cell Research & Therapy 2018 9:152

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  15. Content type: Research

    Aging is one of the key factors that regulate the function of human bone marrow mesenchymal stem cells (hBM-MSCs) and related changes in microRNA (miRNA) expression. However, data reported on aging-related miR...

    Authors: Jun Dong, Zhenhui Zhang, Hongshen Huang, Pei Mo, Chuanfan Cheng, Jianwei Liu, Weizhao Huang, Chaowei Tian, Chongyu Zhang and Jiao Li

    Citation: Stem Cell Research & Therapy 2018 9:151

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  16. Content type: Short report

    Thromboangiitis obliterans (TAO), also known as Buerger’s Disease, is an occlusive vasculitis linked with high morbidity and amputation risk. To date, TAO is deemed incurable due to the lack of a definitive tr...

    Authors: Jorge D. Martin-Rufino, Francisco S. Lozano, Alba M. Redondo, Eva M. Villaron, Raquel Rueda, Rafael Fernandez-Samos and Fermin Sanchez-Guijo

    Citation: Stem Cell Research & Therapy 2018 9:150

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  17. Content type: Research

    Although typically cultured at an atmospheric oxygen concentration (20–21%), adipose-derived stem cells (ASCs) reside under considerable low oxygen tension (physioxia) in vivo. In the present study, we explore...

    Authors: Chang Chen, Qi Tang, Yan Zhang, Mei Yu, Wei Jing and Weidong Tian

    Citation: Stem Cell Research & Therapy 2018 9:148

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  18. Content type: Research

    Human induced pluripotent stem cells-derived mesenchymal stem cells (iPSC-MSCs) have been shown to be effective in Type 2 helper T cells (Th2)-dominant eosinophilic allergic airway inflammation. However, the r...

    Authors: Shu-Bin Fang, Hong-Yu Zhang, Ai-Yun Jiang, Xing-Liang Fan, Yong-Dong Lin, Cheng-Lin Li, Cong Wang, Xiang-Ci Meng and Qing-Ling Fu

    Citation: Stem Cell Research & Therapy 2018 9:147

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  19. Content type: Research

    Endometrial regenerative cells (ERCs), a novel type of mesenchymal-like stem cell derived from menstrual blood, have been recently evaluated as an attractive candidate source in ulcerative colitis (UC); howeve...

    Authors: Xiaoxi Xu, Yong Wang, Baoren Zhang, Xu Lan, Shanzheng Lu, Peng Sun, Xiang Li, Ganggang Shi, Yiming Zhao, Hongqiu Han, Caigan Du and Hao Wang

    Citation: Stem Cell Research & Therapy 2018 9:146

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  20. Content type: Research

    The ability of mesenchymal stem cells (MSCs) to migrate to the desired tissues or lesions is crucial for stem cell-based regenerative medicine and tissue engineering. Optimal therapeutics for promoting MSC mig...

    Authors: Yingchi Zhang, Jiyuan Yan, Haoran Xu, Yong Yang, Wenkai Li, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2018 9:143

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  21. Content type: Research

    Multiple myeloma (MM) currently remains largely incurable. Cancer stem cells (CSCs) are believed to be responsible for drug resistance and eventual relapse. In this study, we exploited a novel agent to evaluat...

    Authors: Fangfang Shi, Miao Li, Jing Wang, Di Wu, Meng Pan, Mei Guo and Jun Dou

    Citation: Stem Cell Research & Therapy 2018 9:144

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  22. Content type: Research

    Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these process...

    Authors: Rami Anderi, Nehman Makdissy, Albert Azar, Francine Rizk and Aline Hamade

    Citation: Stem Cell Research & Therapy 2018 9:141

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