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  1. Acute hypoxic proximal tubule (PT) injury and subsequent maladaptive repair present high mortality and increased risk of acute kidney injury (AKI) - chronic kidney disease (CKD) transition. Human bone marrow m...

    Authors: Sefa Burak Çam, Eda Çiftci, Nazlıhan Gürbüz, Bülent Altun and Petek Korkusuz
    Citation: Stem Cell Research & Therapy 2024 15:105
  2. Microglia, the brain’s resident immune cells, play vital roles in brain development, and disorders like Alzheimer’s disease (AD). Human iPSC-derived microglia (iMG) provide a promising model to study these pro...

    Authors: Imdadul Haq, Jason C. Ngo, Nainika Roy, Richard L. Pan, Nadiya Nawsheen, Rebecca Chiu, Ya Zhang, Masashi Fujita, Rajesh K. Soni, Xuebing Wu, David A. Bennett, Vilas Menon, Marta Olah and Falak Sher
    Citation: Stem Cell Research & Therapy 2024 15:104
  3. Oral ulcers are a common side effect of chemotherapy and affect patients’ quality of life. While stem cell transplantation is a potential treatment for oral ulcers, its efficacy is limited as the stem cells te...

    Authors: Hyun Seok Ryu, Celine Abueva, Andrew Padalhin, So Young Park, Seung Hyeon Yoo, Hwee Hyon Seo, Phil-Sang Chung and Seung Hoon Woo
    Citation: Stem Cell Research & Therapy 2024 15:103
  4. Premature ovarian insufficiency (POI) is a major cause of infertility. In this study, we aimed to investigate the effects of the combination of bone marrow mesenchymal stem cells (BMSCs) and moxibustion (BMSCs...

    Authors: Ge Lu, Hong-xiao Li, Zi-wei Song, Jia Luo, Yan-liang Fan, Yao-li Yin, Jie Shen and Mei-hong Shen
    Citation: Stem Cell Research & Therapy 2024 15:102
  5. In response to the growing demand for organ substitutes, tissue engineering has evolved significantly. However, it is still challenging to create functional tissues and organs. Tissue engineering from the ‘bot...

    Authors: Yichen Zhan, Wenbin Jiang, Zhirong Liu, Zhenxing Wang, Ke Guo and Jiaming Sun
    Citation: Stem Cell Research & Therapy 2024 15:101
  6. Erythroid and myeloid differentiation disorders are commonly occurred in leukemia. Given that the relationship between erythroid and myeloid lineages is still unclear. To find the co-regulators in erythroid an...

    Authors: Yimeng Zhang, Ya Zhou, Xiaohong Li, Xu Pan, Ju Bai, Yijin Chen, Zhenyang Lai, Qiang Chen, Feng Ma and Yong Dong
    Citation: Stem Cell Research & Therapy 2024 15:100
  7. Human induced pluripotent stem cell (iPSC)-derived peripheral sensory neurons present a valuable tool to model human diseases and are a source for applications in drug discovery and regenerative medicine. Clin...

    Authors: Anil Kumar Kalia, Corinna Rösseler, Rafael Granja-Vazquez, Ayesha Ahmad, Joseph J. Pancrazio, Anika Neureiter, Mei Zhang, Daniel Sauter, Irina Vetter, Asa Andersson, Gregory Dussor, Theodore J. Price, Benedict J. Kolber, Vincent Truong, Patrick Walsh and Angelika Lampert
    Citation: Stem Cell Research & Therapy 2024 15:99
  8. In vitro chondrogenesis of mesenchymal stromal cells (MSCs) driven by the essential chondro-inducer transforming growth factor (TGF)-β is instable and yields undesired hypertrophic cartilage predisposed to bon...

    Authors: Solvig Diederichs, Simon I. Dreher, Sarah Anna Nüesch, Sven Schmidt, Christian Merle and Wiltrud Richter
    Citation: Stem Cell Research & Therapy 2024 15:98
  9. DNA damage and oxidative stress induced by chemotherapy are important factors in the onset of premature ovarian insufficiency (POI). Studies have shown that mitochondria derived from mesenchymal stem cells (MS...

    Authors: Shengjie Liu, Yuanmei Wang, Hanlin Yang, Jun Tan, Jingkaiwen Zhang and Dan Zi
    Citation: Stem Cell Research & Therapy 2024 15:97
  10. Ovarian ageing is one of the major issues that impacts female fertility. Mesenchymal stem cell (MSC)-based therapy has made impressive progress in recent years. However, the efficacy and safety of MSCs, as non...

    Authors: Wendi Pei, Lin Fu, Wenhuan Guo, Yibo Wang, Yong Fan, Rui Yang, Rong Li, Jie Qiao and Yang Yu
    Citation: Stem Cell Research & Therapy 2024 15:96
  11. Human adipose stromal cells-derived extracellular vesicles (haMSC-EVs) have been shown to alleviate inflammation in acute lung injury (ALI) animal models. However, there are few systemic studies on clinical-gr...

    Authors: Jing Wang, Zhong-jin Chen, Ze-yi Zhang, Mei-ping Shen, Bo Zhao, Wei Zhang, Ye Zhang, Ji-gang Lei, Cheng-jie Ren, Jing Chang, Cui-li Xu, Meng Li, Yang-yang Pi, Tian-lun Lu, Cheng-xiang Dai, Su-ke Li…
    Citation: Stem Cell Research & Therapy 2024 15:95
  12. Spinal Muscular Atrophy (SMA) is an autosomal-recessive neuromuscular disease affecting children. It is caused by the mutation or deletion of the survival motor neuron 1 (SMN1) gene resulting in lower motor neuro...

    Authors: Federica Virla, Ermanna Turano, Ilaria Scambi, Lorenzo Schiaffino, Marina Boido and Raffaella Mariotti
    Citation: Stem Cell Research & Therapy 2024 15:94
  13. Spermatogonial stem cells (SSCs) were considered to be stem cells with limited potencies due to their existence in adult organisms. However, the production of spermatogonial stem cell colonies with broader dif...

    Authors: Sivankutty Indu, Anandavally N. Devi, Mahitha Sahadevan, Jeeva Sengottaiyan, Asmita Basu, Shabith Raj K and Pradeep G. Kumar
    Citation: Stem Cell Research & Therapy 2024 15:93
  14. Previously, we have demonstrated that the batch variations of human platelet lysate (conventional MSC expansion medium) induce MSC heterogeneity and therapeutic inconsistency. On the other hand, the MSCs expan...

    Authors: Shaoquan Shi, Si Chen, Bowei Liang, Yumeng Li, Qi Ma, Meiqi Li, Jingting Zhang, Lan Yao and Jianyong Xu
    Citation: Stem Cell Research & Therapy 2024 15:92
  15. Musculoskeletal disorders are the leading causes of physical disabilities worldwide. The poor self-repair capacity of musculoskeletal tissues and the absence of effective therapies have driven the development ...

    Authors: Chenrui Yuan, Wei Song, Xiping Jiang, Yifei Wang, Chenkai Li, Weilin Yu and Yaohua He
    Citation: Stem Cell Research & Therapy 2024 15:91
  16. Premature ovarian insufficiency (POI) is an essential cause of reduced fertility and quality of life in young women. Mesenchymal stem cells (MSCs) and MSCs-derived extracellular vesicles (EVs) have the ability...

    Authors: Yinhua Song, Jiachen Wu, Yang Liu, Na Xu, Hualin Bai, Lingjuan Wang, Jihui Ai and Kezhen Li
    Citation: Stem Cell Research & Therapy 2024 15:90
  17. Human pluripotent stem cells (hPSCs) have an enormous therapeutic potential, but large quantities of cells will need to be supplied by reliable, economically viable production processes. The suspension culture...

    Authors: Kevin Ullmann, Felix Manstein, Wiebke Triebert, Nils Kriedemann, Annika Franke, Jana Teske, Mira Mertens, Victoria Lupanow, Gudrun Göhring, Alexandra Haase, Ulrich Martin and Robert Zweigerdt
    Citation: Stem Cell Research & Therapy 2024 15:89
  18. Authors: Mathew Blurton-Jones, Brian Spencer, Sara Michael, Nicholas A. Castello, Andranik A. Agazaryan, Joy L. Davis, Franz-Josef Müller, Jeanne F. Loring, Eliezer Masliah and Frank M. LaFerla
    Citation: Stem Cell Research & Therapy 2024 15:88

    The original article was published in Stem Cell Research & Therapy 2014 5:46

  19. The clinical application of human bone-marrow derived mesenchymal stem cells (MSCs) for the treatment of refractory diseases has achieved remarkable results. However, there is a need for a systematic evaluatio...

    Authors: Miao Hao, Hongyu Jiang, Yuan Zhao, Chunyi Li and Jinlan Jiang
    Citation: Stem Cell Research & Therapy 2024 15:87
  20. In the study published by Sun et al., a systematic review and meta-analysis illustrated the advantageous of stem cell therapy in diabetic foot and can improve the quality of life of patients. Nevertheless, the...

    Authors: Yan Bai and Fan Zhang
    Citation: Stem Cell Research & Therapy 2024 15:85

    The original article was published in Stem Cell Research & Therapy 2022 13:416

    The Commentary to this article has been published in Stem Cell Research & Therapy 2024 15:86

  21. Chemotherapy-induced alopecia (CIA) is a distressing adverse effect of chemotherapy, with an estimated incidence of 65% and limited treatment options. Cyclophosphamide (CYP) is a common alopecia-inducing chemo...

    Authors: Hui Chen, Satoshi Yamaguchi, Yilin Wang, Kento Kaminogo, Kiyoshi Sakai and Hideharu Hibi
    Citation: Stem Cell Research & Therapy 2024 15:84
  22. Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease caused by a gain-of-function mutation in ACVR1, which is a bone morphogenetic protein (BMP) type I receptor. Moreover, it causes progressiv...

    Authors: Pan Gao, Yoshiko Inada, Akitsu Hotta, Hidetoshi Sakurai and Makoto Ikeya
    Citation: Stem Cell Research & Therapy 2024 15:83
  23. Authors: Helena Debiazi Zomer, Victor Juan de Souza Lima, Monique Coelho Bion, Karynne Nazare Lins Brito, Michele Rode, Marco Augusto Stimamiglio, Talita da Silva Jeremias and Andrea Gonçalves Trentin
    Citation: Stem Cell Research & Therapy 2024 15:82

    The original article was published in Stem Cell Research & Therapy 2024 15:15

  24. Human corneal endothelial cells lack regenerative capacity through cell division in vivo. Consequently, in the case of trauma or dystrophy, the only available treatment modality is corneal tissue or primary corne...

    Authors: Pyry Grönroos, Anni Mörö, Paula Puistola, Karoliina Hopia, Maija Huuskonen, Taina Viheriälä, Tanja Ilmarinen and Heli Skottman
    Citation: Stem Cell Research & Therapy 2024 15:81
  25. Despite advances in neonatal care, the incidence of Bronchopulmonary Dysplasia (BPD) remains high among preterm infants. Human induced pluripotent stem cells (hiPSCs) have shown promise in repairing injury in ...

    Authors: Hala Saneh, Heather Wanczyk, Joanne Walker and Christine Finck
    Citation: Stem Cell Research & Therapy 2024 15:80
  26. The discovery of material transfer between transplanted and host mouse photoreceptors has expanded the possibilities for utilizing transplanted photoreceptors as potential vehicles for delivering therapeutic c...

    Authors: Margaret T. Ho, Kotoe Kawai, Dhana Abdo, Lacrimioara Comanita, Arturo Ortin-Martinez, Yui Ueno, Emily Tsao, Azam Rastgar-Moghadam, Chang Xue, Hong Cui, Valerie A. Wallace and Molly S. Shoichet
    Citation: Stem Cell Research & Therapy 2024 15:79
  27. Drug induced bile duct injury is a frequently observed clinical problem leading to a wide range of pathological features. During the past decades, several agents have been identified with various postulated me...

    Authors: Zhenguo Wang, Chen Xing, Luc J. W. van der Laan, Monique M. A. Verstegen, Bart Spee and Rosalinde Masereeuw
    Citation: Stem Cell Research & Therapy 2024 15:78
  28. Mesenchymal stem/stromal cells (MSCs) can regenerate tissues through engraftment and differentiation but also via paracrine signalling via extracellular vesicles (EVs). Fetal-derived MSCs (fMSCs) have been sho...

    Authors: Emine Begüm Gençer, Yuk Kit Lor, Fawaz Abomaray, Samir El Andaloussi, Maria Pernemalm, Nidhi Sharma, Daniel W Hagey, André Görgens, Manuela O Gustafsson, Katarina Le Blanc, Mawaddah Asad Toonsi, Lilian Walther-Jallow and Cecilia Götherström
    Citation: Stem Cell Research & Therapy 2024 15:77
  29. A traditional view is that stem cells (SCs) divide slowly. Meanwhile, both embryonic and pluripotent SCs display a shorter cell cycle duration (CCD) in comparison to more committed progenitors (CPs).

    Authors: Tong Xiao, Ugomma C Eze, Alex Charruyer-Reinwald, Tracy Weisenberger, Ayman Khalifa, Brook Abegaze, Gabrielle K Schwab, Rasha H Elsabagh, T. Richard Parenteau, Karl Kochanowski, Merisa Piper, Yumin Xia, Jeffrey B Cheng, Raymond J Cho and Ruby Ghadially
    Citation: Stem Cell Research & Therapy 2024 15:76
  30. Annulus fibrosis (AF) defects have been identified as the primary cause of disc herniation relapse and subsequent disc degeneration following discectomy. Stem cell-based tissue engineering offers a promising a...

    Authors: Li Yu, Honghao Wu, Shumei Zeng, Xiaojian Hu, Yuxu Wu, Jinhong Zhou, Li Yuan, Qingqing Zhang, Charlie Xiang and Zhiyun Feng
    Citation: Stem Cell Research & Therapy 2024 15:75
  31. Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) play a pivotal role in maintaining lifelong hematopoiesis. The distinction between stem cells and other progenitors, as well as the assessment...

    Authors: Shen Wang, Jianzhong Han, Jingru Huang, Khayrul Islam, Yuheng Shi, Yuyuan Zhou, Dongwook Kim, Jane Zhou, Zhaorui Lian, Yaling Liu and Jian Huang
    Citation: Stem Cell Research & Therapy 2024 15:74
  32. Cell- or tissue-based regenerative therapy is an attractive approach to treat heart failure. A tissue patch that can safely and effectively repair damaged heart muscle would greatly improve outcomes for patien...

    Authors: Shigeru Miyagawa, Takuji Kawamura, Emiko Ito, Maki Takeda, Hiroko Iseoka, Junya Yokoyama, Akima Harada, Noriko Mochizuki-Oda, Yukiko Imanishi-Ochi, Junjun Li, Masao Sasai, Fumiyo Kitaoka, Masaki Nomura, Naoki Amano, Tomoko Takahashi, Hiromi Dohi…
    Citation: Stem Cell Research & Therapy 2024 15:73
  33. Hematopoietic acute radiation syndrome (H-ARS) occurring after exposure to ionizing radiation damages bone marrow causing cytopenias, increasing susceptibility to infections and death. We and others have show...

    Authors: John A. Kink, Michael A. Bellio, Matthew H. Forsberg, Alexandra Lobo, Anna S. Thickens, Bryson M. Lewis, Irene M. Ong, Aisha Khan, Christian M. Capitini and Peiman Hematti
    Citation: Stem Cell Research & Therapy 2024 15:72
  34. Liver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor shortage. Hepatocyte transplantation emerged as a viable alternative to liv...

    Authors: Malika Gantier, Raphaël Rispal, Angélique Fourrier, Séverine Ménoret, Frédéric Delbos, Ignacio Anegon and Tuan Huy Nguyen
    Citation: Stem Cell Research & Therapy 2024 15:71
  35. Initially discovered for its ability to regenerate ear holes, the Murphy Roth Large (MRL) mouse has been the subject of multiple research studies aimed at evaluating its ability to regenerate other body tissue...

    Authors: Sarah Bahraoui, Gautier Tejedor, Anne-Laure Mausset-Bonnefont, François Autelitano, Audrey Barthelaix, Claudia Terraza-Aguirre, Vincent Gisbert, Yoan Arribat, Christian Jorgensen, Mingxing Wei and Farida Djouad
    Citation: Stem Cell Research & Therapy 2024 15:70
  36. A significant unmet need in inflammatory bowel disease is the lack of anti-fibrotic agents targeting intestinal fibrosis. This study aimed to investigate the anti-fibrogenic properties and mechanisms of the co...

    Authors: Yoon Jeong Choi, Woo Ram Kim, Duk Hwan Kim, Jee Hyun Kim and Jun Hwan Yoo
    Citation: Stem Cell Research & Therapy 2024 15:69
  37. Mesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic stem/progenitor cells (HSPCs). MSCs derived from human pluripotent stem cells...

    Authors: Ya Zhou, Xinping Cai, Xiuxiu Zhang, Yong Dong, Xu Pan, Mowen Lai, Yimeng Zhang, Yijin Chen, Xiaohong Li, Xia Li, Jiaxin Liu, Yonggang Zhang and Feng Ma
    Citation: Stem Cell Research & Therapy 2024 15:68
  38. Spinal cord injury (SCI) is a serious clinical condition that has pathological changes such as increased neuroinflammation and nerve tissue damage, which eventually manifests as fibrosis of the injured segment...

    Authors: Xiaofeng Du, Desheng Kong, Ruiyun Guo, Boxin Liu, Jingjing He, Jinyu Zhang, Asiamah Ernest Amponsah, Huixian Cui and Jun Ma
    Citation: Stem Cell Research & Therapy 2024 15:67
  39. Mesenchymal stromal cells (MSCs) a potentially effective disease-modulating therapy for diabetic nephropathy (DN) but their clinical translation has been hampered by incomplete understanding of the optimal tim...

    Authors: Jingjing He, Boxin Liu, Xiaofeng Du, Yan Wei, Desheng Kong, Baofeng Feng, Ruiyun Guo, Ernest Amponsah Asiamah, Matthew D. Griffin, Sean O. Hynes, Sanbing Shen, Yan Liu, Huixian Cui, Jun Ma and Timothy O’Brien
    Citation: Stem Cell Research & Therapy 2024 15:66
  40. The multimodal properties of mesenchymal stromal cells (MSCs), particularly their ability to modulate immune responses is of high interest in translational research. Pro-inflammatory, hypoxic, and 3D culture p...

    Authors: Nick Herger, Irina Heggli, Tamara Mengis, Jan Devan, Leonardo Arpesella, Florian Brunner, Oliver Distler and Stefan Dudli
    Citation: Stem Cell Research & Therapy 2024 15:65
  41. Premature ovarian failure (POF) has a profound impact on female reproductive and psychological health. In recent years, the transplantation of umbilical cord-derived mesenchymal stem cells (UC-MSCs) has demons...

    Authors: Jiacheng Shen, Li Wu, Xiaoying Shi, Gang Chen, Tingwei Liu, Fangfang Xu, Xiaocui Xu, Xiaochen Kou, Yanhong Zhao, Hong Wang, Chenfei Wang, Shaorong Gao and Shaohua Xu
    Citation: Stem Cell Research & Therapy 2024 15:64
  42. Spinal ventral root avulsion results in massive motoneuron degeneration with poor prognosis and high costs. In this study, we compared different isoforms of basic fibroblast growth factor 2 (FGF2), overexpress...

    Authors: B. H. M. Lima, L. P. Cartarozzi, S. Kyrylenko, R. S. Ferreira Jr., B. Barraviera and Alexandre L. R. Oliveira
    Citation: Stem Cell Research & Therapy 2024 15:63
  43. Striae distensae is a disfiguring atrophic skin condition that impairs the body’s aesthetic image. Despite the variety of conducted studies, there is controversy regarding the best modalities. Human mesenchyma...

    Authors: Elham Behrangi, Masoomeh Feizollahi, Sona Zare, Azadeh Goodarzi, Mohammad Reza Ghasemi, Afsaneh Sadeghzadeh-Bazargan, Abbas Dehghani, Maryam Nouri, Roya Zeinali, Masoomeh Roohaninasab and Mohammad Ali Nilforoushzadeh
    Citation: Stem Cell Research & Therapy 2024 15:62
  44. Mesenchymal stromal cells (MSCs) are increasingly employed in regenerative medicine approaches for their immunomodulatory and anti-inflammatory properties, which are encoded in their secretome including extrac...

    Authors: Alexander Otahal, Karina Kramer, Markus Neubauer, Slavomira Gulová, Zsombor Lacza, Stefan Nehrer and Andrea De Luna
    Citation: Stem Cell Research & Therapy 2024 15:61
  45. The diarylheptanoid ASPP 049 has improved the quality of adult hematopoietic stem cell (HSC) expansion ex vivo through long-term reconstitution in animal models. However, its effect on hematopoietic regenerati...

    Authors: Umnuaychoke Thongsa-ad, Anongnat Wongpan, Wasinee Wongkummool, Phaewa Chaiwijit, Kwanchanok Uppakara, Gorawin Chaiyakitpattana, Passanan Singpant, Pirut Tong-ngam, Amnat Chukhan, Wachirachai Pabuprappap, Sirapope Wongniam, Apichart Suksamrarn, Suradej Hongeng, Usanarat Anurathapan, Kasem Kulkeaw, Alisa Tubsuwan…
    Citation: Stem Cell Research & Therapy 2024 15:60
  46. Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and blood–brain barrier function, and pericyte dysfunction may contribute to...

    Authors: Natalie E. King, Jo-Maree Courtney, Lachlan S. Brown, Alastair J. Fortune, Nicholas B. Blackburn, Jessica L. Fletcher, Jake M. Cashion, Jana Talbot, Alice Pébay, Alex W. Hewitt, Gary P. Morris, Kaylene M. Young, Anthony L. Cook and Brad A. Sutherland
    Citation: Stem Cell Research & Therapy 2024 15:59
  47. Currently, no approved stem cell-based therapies for preserving ovarian function during aging. To solve this problem, we developed a long-term treatment for human embryonic stem cell-derived mesenchymal progen...

    Authors: Eun-Young Shin, Suji Jeong, Jeoung Eun Lee, Dong Seok Jeong, Dong Keun Han, Seok-Ho Hong and Dong Ryul Lee
    Citation: Stem Cell Research & Therapy 2024 15:58
  48. Human induced pluripotent stem (iPS) cell-derived enterocyte-like cells (ELCs) are expected to be useful for evaluating the intestinal absorption and metabolism of orally administered drugs. However, it is dif...

    Authors: Tatsuya Inui, Yusei Uraya, Jumpei Yokota, Tomoki Yamashita, Kanae Kawai, Kentaro Okada, Yukiko Ueyama-Toba and Hiroyuki Mizuguchi
    Citation: Stem Cell Research & Therapy 2024 15:57
  49. Authors: Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell and Fabien Gosselet
    Citation: Stem Cell Research & Therapy 2024 15:50

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