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  1. Content type: Research

    Autologous epidermal basal cell suspension therapy has been proven to be one of the most effective treatments for full-thickness wounds. However, we found there remain obvious defects that significantly confin...

    Authors: Peng Wang, Zhicheng Hu, Xiaoling Cao, Shaobin Huang, Yunxian Dong, Pu Cheng, Hailin Xu, Bin Shu, Julin Xie, Jun Wu, Bing Tang and Jiayuan Zhu

    Citation: Stem Cell Research & Therapy 2019 10:154

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  2. Content type: Review

    Stem cell therapy has been applied in many fields. Basic and clinical studies on stem cell therapy for acute kidney injury (AKI) have been conducted. Stem cells have been found to exert renal protection throug...

    Authors: Si-Yang Wang, Quan Hong, Chao-Yang Zhang, Yuan-Jun Yang, Guang-Yan Cai and Xiang-Mei Chen

    Citation: Stem Cell Research & Therapy 2019 10:281

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  3. Content type: Research

    The incidence of obesity and diabetes is increasing rapidly. Optimal management is still elusive. Obesity associated with type 2 diabetes is known to cause adipose tissue inflammation, increase oxidative stres...

    Authors: Cleyton C. Domingues, Nabanita Kundu, Yana Kropotova, Neeki Ahmadi and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2019 10:280

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  4. Content type: Research

    Autograft microskin transplantation has been widely used as a skin graft therapy in full-thickness skin defect. However, skin grafting failure can lead to a pathological delay wound healing due to a poor vascu...

    Authors: Yuansen Luo, Xiaoyou Yi, Tangzhao Liang, Shihai Jiang, Ronghan He, Ying Hu, Li Bai, Chunmei Wang, Kun Wang and Lei Zhu

    Citation: Stem Cell Research & Therapy 2019 10:279

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  5. Content type: Review

    Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communi...

    Authors: Na Li, Lu Zhao, Yankai Wei, Vicki L. Ea, Hong Nian and Ruihua Wei

    Citation: Stem Cell Research & Therapy 2019 10:278

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  6. Content type: Research

    Chrysosplenetin is an O-methylated flavonol compound isolated from the plant Chamomilla recutita and Laggera pterodonta. The aim of our research is to evaluate the function of Chrysosplenetin on osteogenesis of h...

    Authors: Guoju Hong, Xiaoming He, Yingshan Shen, Xiaojun Chen, Fang Yang, Peng Yang, Fengxiang Pang, Xiaorui Han, Wei He and Qiushi Wei

    Citation: Stem Cell Research & Therapy 2019 10:277

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  7. Content type: Research

    Tooth loss caused by caries or injuries has a negative effect on human health; thus, it is important to develop a reliable method of tooth regeneration. Research on tooth regeneration has mainly focused on mou...

    Authors: Qian Li, Siqi Zhang, Yi Sui, Xiaoming Fu, Yan Li and Shicheng Wei

    Citation: Stem Cell Research & Therapy 2019 10:276

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  8. Content type: Research

    Hypertrophic scars (HSs) are formed via an aberrant response to the wound healing process. HSs can be cosmetic or can result in functional problems. Prolonged proliferation and remodeling phases disrupt wound ...

    Authors: Ching-Hsuan Hu, Yi-Wen Tseng, Chih-Yung Chiou, Kuan-Chun Lan, Chih-Hung Chou, Chun-San Tai, Hsien-Da Huang, Chiung-Wen Hu, Ko-Hsun Liao, Shiow-Shuh Chuang, Jui-Yung Yang and Oscar K. Lee

    Citation: Stem Cell Research & Therapy 2019 10:275

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  9. Content type: Research

    Retrotransposition of protein-coding genes is thought to occur due to the existence of numerous processed pseudogenes in both animals and plants. Unlike retrotransposons including Alu and LINE-1, direct evidence ...

    Authors: Saki Aoto, Saki Katagiri, Yi Wang, Alistair T. Pagnamenta, Rie Sakamoto-Abutani, Masashi Toyoda, Akihiro Umezawa and Kohji Okamura

    Citation: Stem Cell Research & Therapy 2019 10:273

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  10. Content type: Research

    Oligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS. Oligodendrocyte death and defects are the leading causes of s...

    Authors: Poommaree Namchaiw, Han Wen, Florian Mayrhofer, Olga Chechneva, Sangita Biswas and Wenbin Deng

    Citation: Stem Cell Research & Therapy 2019 10:272

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  11. Content type: Research

    Male infertility is a serious social problem in modern society. Nonobstructive azoospermia (NOA) caused by germ cell gene defects is an important reason for male infertility, but effective clinical treatment f...

    Authors: Xiaoyu Li, Tiecheng Sun, Xiuxia Wang, Jixin Tang and Yixun Liu

    Citation: Stem Cell Research & Therapy 2019 10:271

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  12. Content type: Research

    Testicular torsion is an urological emergency that may lead to infertility due to ischemic injury. Promptly surgical correction by orchiopexy is the only way to avoid infertility and no effective treatment for...

    Authors: Chi-Hao Hsiao, Andrea Tung-Qian Ji, Chih-Cheng Chang, Ming-Hsien Chien, Liang-Ming Lee and Jennifer Hui-Chun Ho

    Citation: Stem Cell Research & Therapy 2019 10:270

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  13. Content type: Research

    Adult stem cells and progenitors are responsible for breast tissue regeneration. Human breast epithelial progenitors are organized in a lineage hierarchy consisting of bipotent progenitors (BPs), myoepithelial...

    Authors: Vasudeva Bhat, Victoria Lee-Wing, Pingzhao Hu and Afshin Raouf

    Citation: Stem Cell Research & Therapy 2019 10:269

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  14. Content type: Research

    PBX homeobox 1 (PBX1) is involved in the maintenance of the pluripotency of human embryonic and hematopoietic stem cells; however, the effects of PBX1 in the self-renewal and reprogramming of hair follicle mes...

    Authors: Yixu Jiang, Feilin Liu, Fei Zou, Yingyao Zhang, Bo Wang, Yuying Zhang, Aobo Lian, Xing Han, Zinan Liu, Xiaomei Liu, Minghua Jin, Dianliang Wang, Gang Li and Jinyu Liu

    Citation: Stem Cell Research & Therapy 2019 10:268

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  15. Content type: Research

    To investigate the therapeutic effect of intercellular adhesion molecule (ICAM)-1-modified mesenchymal stem cells (MSCs) in a mouse model of inflammatory bowel disease (IBD) induced by dextran sulfate sodium.

    Authors: Xin Li, Qian Wang, Li Ding, Yu-Xing Wang, Zhi-Dong Zhao, Ning Mao, Chu-Tse Wu, Hua Wang, Heng Zhu and Shou-Bin Ning

    Citation: Stem Cell Research & Therapy 2019 10:267

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  16. Content type: Research

    Mesenchymal stem cells (MSCs) have been recognized as a promising tool for the treatment of various inflammatory disorders and autoimmune diseases. Stress conditions affect immune-mediated treatment and activa...

    Authors: Shuizhong Cen, Peng Wang, Zhongyu Xie, Rui Yang, Jinteng Li, Zhenhua Liu, Shan Wang, Xiaohua Wu, Wenjie Liu, Ming Li, Su’an Tang, Huiyong Shen and Yanfeng Wu

    Citation: Stem Cell Research & Therapy 2019 10:265

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  17. Content type: Research

    Even though mesenchymal stromal cells (MSCs) mitigate lung and distal organ damage in experimental polymicrobial sepsis, mortality remains high. We investigated whether preconditioning with eicosapentaenoic ac...

    Authors: Johnatas D. Silva, Miquéias Lopes-Pacheco, Ligia L. de Castro, Jamil Z. Kitoko, Stefano A. Trivelin, Natália R. Amorim, Vera L. Capelozzi, Marcelo M. Morales, Bianca Gutfilen, Sergio A. L. de Souza, Daniel J. Weiss, Bruno L. Diaz and Patricia R. M. Rocco

    Citation: Stem Cell Research & Therapy 2019 10:264

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  18. Content type: Research

    Myocardial fibrosis is a common pathophysiological change in cardiovascular disease, which can cause cardiac dysfunction and even sudden death. Excessively activated fibroblasts proliferate and secret excessiv...

    Authors: Fengxia Lin, Zhicong Zeng, Yinzhi Song, Liang Li, Zijun Wu, Xiaoduo Zhang, Zhiwen Li, Xiao Ke and Xun Hu

    Citation: Stem Cell Research & Therapy 2019 10:263

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  19. Content type: Research

    The efficacy of mesenchymal stem cell (MSC)-based therapy for acute liver injury (ALI) involves coordination with the hepatic immune system, a complex and coordinated network of immune-cell interactions. Howev...

    Authors: Jingqi Liu, Bing Feng, Yanping Xu, Jiaqi Zhu, Xudong Feng, Wenyi Chen, Xinyu Sheng, Xiaowei Shi, Qiaoling Pan, Jiong Yu, Xun Zeng, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:262

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  20. Content type: Letter

    Recently published article by Pieri’s group suggested that follicle-stimulating hormone (FSH) activates canine testicular spermatogonial stem cells (SSCs) and results in increased expression of pluripotent mar...

    Authors: Hiren Patel and Deepa Bhartiya

    Citation: Stem Cell Research & Therapy 2019 10:261

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  21. Content type: Review

    Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently expanded in vitro. The identity of synovial-derived cells has l...

    Authors: Fangqi Li, Yiyong Tang, Bin Song, Menglei Yu, Qingyue Li, Congda Zhang, Jingyi Hou and Rui Yang

    Citation: Stem Cell Research & Therapy 2019 10:260

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  22. Content type: Research

    Mesenchymal stem cells (MSCs) have emerged as a promising therapy for type 2 diabetes (T2D). Mechanistic researches demonstrate that the anti-diabetic effect of MSCs is partially mediated by eliciting macropha...

    Authors: Jieqing Gao, Yu Cheng, Haojie Hao, Yaqi Yin, Jing Xue, Qi Zhang, Lin Li, Jiejie Liu, Zongyan Xie, Songyan Yu, Bing Li, Weidong Han and Yiming Mu

    Citation: Stem Cell Research & Therapy 2019 10:259

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  23. Content type: Research

    Liver organoid technology holds great promises to be used in large-scale population-based drug screening and in future regenerative medicine strategies. Recently, some studies reported robust protocols for gen...

    Authors: Ernesto Goulart, Luiz Carlos de Caires-Junior, Kayque Alves Telles-Silva, Bruno Henrique Silva Araujo, Gerson S. Kobayashi, Camila Manso Musso, Amanda Faria Assoni, Danyllo Oliveira, Elia Caldini, Jonathan A. Gerstenhaber, Silvano Raia, Peter I. Lelkes and Mayana Zatz

    Citation: Stem Cell Research & Therapy 2019 10:258

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  24. Content type: Short report

    Human adipose-derived stromal cells (hASCs) have been gaining increasing popularity in regenerative medicine thanks to their multipotency, ease of collection, and efficient culture. Similarly to other stromal ...

    Authors: Mirasbek Kuterbekov, Paul Machillot, Francis Baillet, Alain M. Jonas, Karine Glinel and Catherine Picart

    Citation: Stem Cell Research & Therapy 2019 10:256

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  25. Content type: Research

    Obesity impairs a variety of cell types including adipose-derived mesenchymal stem cells (ASCs). ASCs are indispensable for tissue homeostasis/repair, immunomodulation, and cell renewal. It has been demonstrat...

    Authors: Andreas Ritter, Nina-Naomi Kreis, Susanne Roth, Alexandra Friemel, Lukas Jennewein, Christine Eichbaum, Christine Solbach, Frank Louwen and Juping Yuan

    Citation: Stem Cell Research & Therapy 2019 10:255

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  26. Content type: Research

    Stem cell-based bone tissue engineering shows promise for bone repair but faces some challenges, such as insufficient osteogenesis and limited architecture flexibility of the cell-delivery scaffold.

    Authors: Hang Lin, Ying Tang, Thomas P. Lozito, Nicholas Oyster, Bing Wang and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2019 10:254

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  27. Content type: Research

    For adipose-derived stromal cells (ASCs) to be safe for use in the clinical setting, they need to be prepared using good manufacturing practices (GMPs). Fetal bovine serum (FBS), used to expand ASCs in vitro i...

    Authors: Carla Dessels, Melvin A. Ambele and Michael S. Pepper

    Citation: Stem Cell Research & Therapy 2019 10:253

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  28. Content type: Research

    Taking advantage of cellular paracrine mechanisms, the secretome of adipose-derived stem cells (ADSCs) and adipose tissue has been demonstrated to induce tissue repair and regeneration in various ischemic and ...

    Authors: Yunfan He, Jing Xia, Hsinkai Chen, Liangyue Wang, Chengliang Deng and Feng Lu

    Citation: Stem Cell Research & Therapy 2019 10:252

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  29. Content type: Research

    Autosomal dominant osteopetrosis type II (ADO2) is a rare human genetic disease that has been broadly studied as an important osteopetrosis model; however, there are no disease-specific induced pluripotent ste...

    Authors: Minglin Ou, Chunhong Li, Donge Tang, Wen Xue, Yong Xu, Peng Zhu, Bo Li, Jiansheng Xie, Jiejing Chen, Weiguo Sui, Lianghong Yin and Yong Dai

    Citation: Stem Cell Research & Therapy 2019 10:251

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  30. Content type: Research

    Premature ovarian insufficiency (POI) is one of the leading causes of female infertility, which is caused by an abnormal ovarian reserve. Currently, there is no effective treatment to restore the fertility of ...

    Authors: Ziling Yang, Xin Du, Cunli Wang, Jin Zhang, Conghui Liu, Yu Li and Hong Jiang

    Citation: Stem Cell Research & Therapy 2019 10:250

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  31. Content type: Research

    The generation of functional human epidermal melanocytes (HEM) from stem cells provides an unprecedented source for cell-based therapy in vitiligo. Despite the important efforts exerted to obtain melanin-produ...

    Authors: Gabriela Zavala, Carolina Sandoval, Daniel Meza, Rafael Contreras, Walter Gubelin and Maroun Khoury

    Citation: Stem Cell Research & Therapy 2019 10:249

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  32. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) are considered an important candidate in cell therapy and tissue engineering approaches. The culture of stem cells in a 3D environment is known to better resemble the in v...

    Authors: Dominik Egger, Ana Catarina Oliveira, Barbara Mallinger, Hatim Hemeda, Verena Charwat and Cornelia Kasper

    Citation: Stem Cell Research & Therapy 2019 10:248

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  33. Content type: Research

    Increasing evidence has shown that mesenchymal stem cells (MSCs) yield a favorable therapeutic benefit for thermal burn skin wounds. Human amniotic MSCs (hAMSCs) derived from amniotic membrane have multilineag...

    Authors: Jing-Yuan Li, Kang-Kang Ren, Wen-Jie Zhang, Ling Xiao, Han-You Wu, Qian-Yu Liu, Ting Ding, Xiang-Cheng Zhang, Wen-Jia Nie, Yu Ke, Ke-Yu Deng, Quan-Wen Liu and Hong-Bo Xin

    Citation: Stem Cell Research & Therapy 2019 10:247

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  34. Content type: Research

    Graves’ ophthalmopathy (GO) is a complication of Graves’ disease (GD), in which orbital connective tissues become inflamed and increase in volume and orbital fibroblasts within the orbital fat and extraocular ...

    Authors: Mira Park, J. Paul Banga, Gi Jin Kim, MinYoung Kim and Helen Lew

    Citation: Stem Cell Research & Therapy 2019 10:246

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  35. Content type: Research

    Trophoblasts as a specific cell lineage are crucial for the correct function of the placenta. Human trophoblast stem cells (hTSCs) are a proliferative population that can differentiate into syncytiotrophoblast...

    Authors: Zhuosi Li, Osamu Kurosawa and Hiroo Iwata

    Citation: Stem Cell Research & Therapy 2019 10:245

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  36. Content type: Research

    Tissue regeneration disorder after endometrial injury is an important cause of intrauterine adhesions, amenorrhea, and infertility in women. Both bone marrow mesenchymal stem cell (BMSC) transplantation and el...

    Authors: Liangjun Xia, Qingyu Meng, Jin Xi, Qin Han, Jie Cheng, Jie Shen, Youbing Xia and Liyun Shi

    Citation: Stem Cell Research & Therapy 2019 10:244

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  37. Content type: Research

    The balance of oral microbiomes is crucial to maintain oral health. Microecological imbalance can impair the function of mesenchymal stem cells (MSCs) and lead to delay wound healing. Probiotics is a promising...

    Authors: Nannan Han, Lu Jia, Yingying Su, Juan Du, Lijia Guo, Zhenhua Luo and Yi Liu

    Citation: Stem Cell Research & Therapy 2019 10:243

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  38. Content type: Review

    Exosomes are extracellular membranous nanovesicles that mediate local and systemic intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into target cells, thus altering the behav...

    Authors: Pengyu Hong, Hao Yang, Yue Wu, Kun Li and Zhangui Tang

    Citation: Stem Cell Research & Therapy 2019 10:242

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  39. Content type: Commentary

    When studying purified hematopoietic stem cells, the urge for mechanisms and reductionist approaches appears to be overwhelming. The prime focus of the field has recently been on the study of highly purified h...

    Authors: Peter Quesenberry, Theo Borgovan, Chibuikem Nwizu, Mark Dooner and Laura Goldberg

    Citation: Stem Cell Research & Therapy 2019 10:241

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  40. Content type: Research

    Adipose-derived mesenchymal stem cells (ADMSC) are non-haematopoietic, fibroblast-like multipotent progenitor cells. They have the potential for trilineage (adipocyte, chondrocyte and osteocyte) differentiatio...

    Authors: Luise Doering, Rahul Khatri, Sebastian Friedrich Petry, Heinrich Sauer, Hans-Peter Howaldt and Thomas Linn

    Citation: Stem Cell Research & Therapy 2019 10:240

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  41. Content type: Research

    Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-secreting islet β cells by autoreactive T cells. Non-obese diabetic (NOD) mice are the widely used animal model for huma...

    Authors: Min Su, Yujun Lin, Zhixu He and Laijun Lai

    Citation: Stem Cell Research & Therapy 2019 10:239

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  42. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the most common tumors globally, with varying prevalence based on endemic risk factors. Bone morphogenetic protein (BMP) exhibits a broad spectrum of biological activit...

    Authors: Peng-Cheng Feng, Xing-Fei Ke, Hui-Lan Kuang, Li-Li Pan, Qiang Ye and Jian-Bing Wu

    Citation: Stem Cell Research & Therapy 2019 10:237

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  43. Content type: Research

    The differentiation of corneal limbal stem cells (LSCs) from human pluripotent stem cells (hPSCs) has great power as a novel treatment for ocular surface reconstruction and for modeling corneal epithelial rene...

    Authors: Meri Vattulainen, Tanja Ilmarinen, Laura Koivusalo, Keijo Viiri, Heidi Hongisto and Heli Skottman

    Citation: Stem Cell Research & Therapy 2019 10:236

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  44. Content type: Research

    Adipose tissue-derived mesenchymal stromal cells (ASCs) have been shown to exhibit some promising properties of their use in regenerative medicine as advanced therapy medicinal products (ATMP). However, differ...

    Authors: Justyna Czapla, Sybilla Matuszczak, Klaudia Kulik, Ewa Wiśniewska, Ewelina Pilny, Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Sirek, Michał Oskar Zembala, Marian Zembala, Stanisław Szala and Tomasz Cichoń

    Citation: Stem Cell Research & Therapy 2019 10:235

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  45. Content type: Research

    Neurovascular unit restoration is crucial for nerve regeneration, especially in critical gaps of injured peripheral nerve. Multipotent vascular stem cells (MVSCs) harvested from an adult blood vessel are invol...

    Authors: Ching-Wen Huang, Yuan-Yu Hsueh, Wen-Chin Huang, Shyam Patel and Song Li

    Citation: Stem Cell Research & Therapy 2019 10:234

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  46. Content type: Research

    Cancer stem cells always express high levels of stemness-associated transcription factors to maintain their features. However, the regulatory mechanism of the stemness of cancer stem cells mediated by transcri...

    Authors: Fan Yang, Pei Cui, Yu Lu and Xiaobo Zhang

    Citation: Stem Cell Research & Therapy 2019 10:233

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