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  1. Research

    Epigenetic reprogramming converts human Wharton’s jelly mesenchymal stem cells into functional cardiomyocytes by differential regulation of Wnt mediators

    Lineage commitment of mesenchymal stem cells (MSCs) to cardiac differentiation is controlled by transcription factors that are regulated by epigenetic events, mainly histone deacetylation and promoter DNA meth...

    G. Bhuvanalakshmi, Frank Arfuso, Alan Prem Kumar, Arun Dharmarajan and Sudha Warrier

    Stem Cell Research & Therapy 2017 8:185

    Published on: 14 August 2017

  2. Research

    Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix

    Mesenchymal stem cell therapy for osteoarthritis (OA) has been widely investigated, but the mechanisms are still unclear. Exosomes that serve as carriers of genetic information have been implicated in many dis...

    Yafei Wang, Dongsheng Yu, Zhiming Liu, Fang Zhou, Jun Dai, Bingbing Wu, Jing Zhou, Boon Chin Heng, Xiao Hui Zou, Hongwei Ouyang and Hua Liu

    Stem Cell Research & Therapy 2017 8:189

    Published on: 14 August 2017

  3. Research

    Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell apoptosis

    Chemotherapy-induced premature ovarian failure (POF) is a severe complication affecting tumor patients at a childbearing age. Mesenchymal stem cells (MSCs) can partially restore the ovarian structure and funct...

    Xiafei Fu, Yuanli He, Xuefeng Wang, Dongxian Peng, Xiaoying Chen, Xinran Li and Qing Wang

    Stem Cell Research & Therapy 2017 8:187

    Published on: 14 August 2017

  4. Research

    Protein deubiquitinase USP7 is required for osteogenic differentiation of human adipose-derived stem cells

    Human adipose-derived stem cells (hASCs) are multipotent progenitor cells with self-renewal capabilities and multilineage differentiation potential, including osteogenesis. Although protein deubiquitinases hav...

    Yiman Tang, Longwei Lv, Wenyue Li, Xiao Zhang, Yong Jiang, Wenshu Ge and Yongsheng Zhou

    Stem Cell Research & Therapy 2017 8:186

    Published on: 14 August 2017

  5. Research

    Angiogenic potency evaluation of cell therapy candidates by a novel application of the in vitro aortic ring assay

    Due to limitations of current angiogenesis assays, we aimed to develop a novel application of the rat aortic ring assay to assess the angiogenic potential of mesenchymal stromal cells (MSCs). First-trimester h...

    Farwah Iqbal, Peter Szaraz, Matthew Librach, Andrée Gauthier-Fisher and Clifford L. Librach

    Stem Cell Research & Therapy 2017 8:184

    Published on: 14 August 2017

  6. Research

    Mesenchymal stromal cells ameliorate oxidative stress-induced islet endothelium apoptosis and functional impairment via Wnt4-β-catenin signaling

    Islet dysfunction and destruction are the common cause for both type 1 and type 2 diabetes mellitus (T2DM). The islets of Langerhans are highly vascularized miniorgans, and preserving the structural integrity ...

    Lingshu Wang, Li Qing, He Liu, Na Liu, Jingting Qiao, Chen Cui, Tianyi He, Ruxing Zhao, Fuqiang Liu, Fei Yan, Chuan Wang, Kai Liang, Xinghong Guo, Ying H. Shen, Xinguo Hou and Li Chen

    Stem Cell Research & Therapy 2017 8:188

    Published on: 14 August 2017

  7. Research

    Inhibitory effects of HNF4α on migration/maltransformation of hepatic progenitors: HNF4α-overexpressing hepatic progenitors for liver repopulation

    Although they are expandable in vitro, hepatic progenitors are immature cells and share many immunomarkers with hepatocellular carcinoma, raising potential concerns regarding maltransformation after transplant...

    Ping Wang, Min Cong, Tianhui Liu, Hufeng Xu, Lin Wang, Guangyong Sun, Aiting Yang, Dong Zhang, Jian Huang, Yameng Sun, Wenshan Zhao, Hong Ma, Jidong Jia and Hong You

    Stem Cell Research & Therapy 2017 8:183

    Published on: 14 August 2017

  8. Research

    Determination of optimized oxygen partial pressure to maximize the liver regenerative potential of the secretome obtained from adipose-derived stem cells

    A hypoxic-preconditioned secretome from stem cells reportedly promotes the functional and regenerative capacity of the liver more effectively than a control secretome. However, the optimum oxygen partial press...

    Sang Chul Lee, Kee-Hwan Kim, Ok-Hee Kim, Sang Kuon Lee, Ha-Eun Hong, Seong Su Won, Sang-Jin Jeon, Byung Jo Choi, Wonjun Jeong and Say-June Kim

    Stem Cell Research & Therapy 2017 8:181

    Published on: 3 August 2017

  9. Research

    Curcumin induces therapeutic angiogenesis in a diabetic mouse hindlimb ischemia model via modulating the function of endothelial progenitor cells

    Neovascularization is impaired in diabetes mellitus, which leads to the development of peripheral arterial disease and is mainly attributed to the dysfunction of endothelial progenitor cells (EPCs). Previous s...

    Jinzhi You, Jiacheng Sun, Teng Ma, Ziying Yang, Xu Wang, Zhiwei Zhang, Jingjing Li, Longgang Wang, Masaaki Ii, Junjie Yang and Zhenya Shen

    Stem Cell Research & Therapy 2017 8:182

    Published on: 3 August 2017

  10. Research

    CD106 is a novel mediator of bone marrow mesenchymal stem cells via NF-κB in the bone marrow failure of acquired aplastic anemia

    Acquired aplastic anemia (AA) is characterized by deficiency or dysfunction of the bone marrow (BM) microenvironment. However, little is known about the impairment of BM-derived mesenchymal stem cells (MSCs) i...

    Shihong Lu, Meili Ge, Yizhou Zheng, Jianping Li, Xiaoming Feng, Sizhou Feng, Jinbo Huang, Ying Feng, Donglin Yang, Jun Shi, Fang Chen and Zhongchao Han

    Stem Cell Research & Therapy 2017 8:178

    Published on: 1 August 2017

  11. Research

    Mesenchymal stem cells derived from inflamed dental pulpal and gingival tissue: a potential application for bone formation

    Chronic periodontal disease is an infectious disease consisting of prolonged inflammation of the supporting tooth tissue and resulting in bone loss. Guided bone regeneration procedures have become common and s...

    Laura Tomasello, Rodolfo Mauceri, Antonina Coppola, Maria Pitrone, Giuseppe Pizzo, Giuseppina Campisi, Giuseppe Pizzolanti and Carla Giordano

    Stem Cell Research & Therapy 2017 8:179

    Published on: 1 August 2017

  12. Research

    Different therapeutic effects of cells derived from human amniotic membrane on premature ovarian aging depend on distinct cellular biological characteristics

    Many reports have shown that various kinds of stem cells have the ability to recover premature ovarian aging (POA) function. Transplantation of human amniotic epithelial cells (hAECs) improves ovarian function...

    Chenyue Ding, Hong Li, Yun Wang, Fuxin Wang, Huihua Wu, Rulei Chen, Jinghuan Lv, Wei Wang and Boxian Huang

    Stem Cell Research & Therapy 2017 8:173

    Published on: 27 July 2017

  13. Research

    Extracellular vesicles from human liver stem cells restore argininosuccinate synthase deficiency

    Argininosuccinate synthase (ASS)1 is a urea cycle enzyme that catalyzes the conversion of citrulline and aspartate to argininosuccinate. Mutations in the ASS1 gene cause citrullinemia type I, a rare autosomal ...

    Maria Beatriz Herrera Sanchez, Sara Previdi, Stefania Bruno, Valentina Fonsato, Maria Chiara Deregibus, Sharad Kholia, Sara Petrillo, Emanuela Tolosano, Rossana Critelli, Marco Spada, Renato Romagnoli, Mauro Salizzoni, Ciro Tetta and Giovanni Camussi

    Stem Cell Research & Therapy 2017 8:176

    Published on: 27 July 2017

  14. Research

    Human dental pulp pluripotent-like stem cells promote wound healing and muscle regeneration

    Dental pulp represents an easily accessible autologous source of adult stem cells. A subset of these cells, named dental pulp pluripotent-like stem cells (DPPSC), shows high plasticity and can undergo multiple...

    Ester Martínez-Sarrà, Sheyla Montori, Carlos Gil-Recio, Raquel Núñez-Toldrà, Domiziana Costamagna, Alessio Rotini, Maher Atari, Aernout Luttun and Maurilio Sampaolesi

    Stem Cell Research & Therapy 2017 8:175

    Published on: 27 July 2017

  15. Research

    Harvesting multipotent progenitor cells from a small sample of tonsillar biopsy for clinical applications

    Human adult stem cells hold the potential for the cure of numerous conditions and degenerative diseases. They possess major advantages over pluripotent stem cells as they can be derived from donors at any age,...

    Raju Khatri, Michal Arad, Timothy Ortlip, Benjamin A. Portney, W. Alex Meltzer, Silviu Diaconu, Lorna E. Silipino, Ying Wang, David M. Kaetzel, Rodney J. Taylor and Michal Zalzman

    Stem Cell Research & Therapy 2017 8:174

    Published on: 27 July 2017

  16. Research

    Culturing and transcriptome profiling of progenitor-like colonies derived from adult mouse pancreas

    Transplantation of insulin-producing cells is considered an important diabetes therapy. Many research studies have shown that insulin-producing cells can be derived from the in-vitro cultured pancreatic coloni...

    Dongshen Ma, Shanshan Tang, Jing Song, Qiong Wu, Fangfang Zhang, Yun Xing, Yi Pan, Yanfeng Zhang, Jingwei Jiang, Yubin Zhang and Liang Jin

    Stem Cell Research & Therapy 2017 8:172

    Published on: 26 July 2017

  17. Research

    Minocycline modulates NFκB phosphorylation and enhances antimicrobial activity against Staphylococcus aureus in mesenchymal stromal/stem cells

    Mesenchymal stromal/stem cells (MSCs) have demonstrated pro-healing properties due to their anti-inflammatory, angiogenic, and even antibacterial properties. We have shown previously that minocycline enhances ...

    Alberto Daniel Guerra, Warren E. Rose, Peiman Hematti and W. John Kao

    Stem Cell Research & Therapy 2017 8:171

    Published on: 21 July 2017

  18. Research

    A small-molecule/cytokine combination enhances hematopoietic stem cell proliferation via inhibition of cell differentiation

    Accumulated evidence supports the potent stimulating effects of multiple small molecules on the expansion of hematopoietic stem cells (HSCs) which are important for the therapy of various hematological disorde...

    Lan Wang, Xin Guan, Huihui Wang, Bin Shen, Yu Zhang, Zhihua Ren, Yupo Ma, Xinxin Ding and Yongping Jiang

    Stem Cell Research & Therapy 2017 8:169

    Published on: 18 July 2017

  19. Research

    Do we really need to differentiate mesenchymal stem cells into insulin-producing cells for attenuation of the autoimmune responses in type 1 diabetes: immunoprophylactic effects of precursors to insulin-producing cells

    Type 1 diabetes (T1D) is a multifactorial autoimmune disorder where pancreatic beta cells are lost before the clinical manifestations of the disease. Administration of mesenchymal stem cells (MSCs) or MSCs dif...

    Anshu Sharma and Rajni Rani

    Stem Cell Research & Therapy 2017 8:167

    Published on: 12 July 2017

  20. Research

    Ang II-AT2R increases mesenchymal stem cell migration by signaling through the FAK and RhoA/Cdc42 pathways in vitro

    Mesenchymal stem cells (MSCs) migrate via the bloodstream to sites of injury and are possibly attracted by inflammatory factors. As a proinflammatory mediator, angiotensin II (Ang II) reportedly enhances the m...

    Xiu-ping Xu, Hong-li He, Shu-ling Hu, Ji-bin Han, Li-li Huang, Jing-yuan Xu, Jian-feng Xie, Ai-ran Liu, Yi Yang and Hai-bo Qiu

    Stem Cell Research & Therapy 2017 8:164

    Published on: 12 July 2017

  21. Research

    Improvement in asymmetric dimethylarginine and oxidative stress in patients with limb salvage after autologous mononuclear stem cell application for critical limb ischemia

    Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, acts as an inhibitor of angiogenesis and is associated with an increased risk of cardiovascular mortality. Administration o...

    Juraj Madaric, Martina Valachovicova, Ludovit Paulis, Jana Pribojova, Renata Mateova, Katarina Sebekova, Luba Postulkova, Terezia Madaricova, Maria Bucova, Martin Mistrik and Ivan Vulev

    Stem Cell Research & Therapy 2017 8:165

    Published on: 12 July 2017

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