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  1. Content type: Research

    Adipose derived stem cells can be stimulated to produce a growth factor rich secretome which enhances axon regeneration. In this study we investigated the importance of exosomes, extracellular vesicles release...

    Authors: Rosanna C Ching, Mikael Wiberg and Paul J Kingham

    Citation: Stem Cell Research & Therapy 2018 9:266

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  2. Content type: Research

    In the bone marrow, MSCs reside in a hypoxic milieu (1–5% O2) that is thought to preserve their multipotent state. Typically, in vitro expansion of MSCs is performed under normoxia (~ 21% O2), a process that has ...

    Authors: Ben Antebi, Luis A Rodriguez II, Kerfoot P Walker III, Amber M Asher, Robin M Kamucheka, Lucero Alvarado, Arezoo Mohammadipoor and Leopoldo C Cancio

    Citation: Stem Cell Research & Therapy 2018 9:265

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  3. Content type: Correction

    The original article [1] contained a minor error regarding the mean diameter of the alginate microcapsules described in relation to Fig. 4 in the Results section. The microcapsules had an actual mean diameter ...

    Authors: Vitor Hugo Santos, João Pedro Hübbe Pfeifer, Jaqueline Brandão de Souza, Betsabéia Heloisa Gentilha Milani, Rogério Antonio de Oliveira, Marjorie Golim Assis, Elenice Deffune, Andrei Moroz and Ana Liz Garcia Alves

    Citation: Stem Cell Research & Therapy 2018 9:259

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    The original article was published in BMC Veterinary Research 2018 14:114

  4. Content type: Correction

    The original article [1] contains numerous value errors in the graphs in Fig. 2b regarding the markers describing the values for total tubule length and mean tubule length without aprotinin at 2.5 mg/ml concen...

    Authors: Severin Mühleder, Karoline Pill, Mira Schaupper, Krystyna Labuda, Eleni Priglinger, Pablo Hofbauer, Verena Charwat, Uwe Marx, Heinz Redl and Wolfgang Holnthoner

    Citation: Stem Cell Research & Therapy 2018 9:261

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    The original article was published in Stem Cell Research & Therapy 2018 9:35

  5. Content type: Correction

    The original article [1] contains a major error carried across the captions of Tables 1, 2, and 3. In each table caption, the data were expressed as “mean ± standard deviation (SD)”; unfortunately, the authors...

    Authors: Fa-Ming Chen, Li-Na Gao, Bei-Min Tian, Xi-Yu Zhang, Yong-Jie Zhang, Guang-Ying Dong, Hong Lu, Qing Chu, Jie Xu, Yang Yu, Rui-Xin Wu, Yuan Yin, Songtao Shi and Yan Jin

    Citation: Stem Cell Research & Therapy 2018 9:260

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    The original article was published in Stem Cell Research & Therapy 2016 7:33

  6. Content type: Correction

    The original article [1] contains a number of small errors which the authors would like to clarify:

    Authors: Bushra Memon, Manale Karam, Sara Al-Khawaga and Essam M. Abdelalim

    Citation: Stem Cell Research & Therapy 2018 9:262

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    The original article was published in Stem Cell Research & Therapy 2018 9:15

  7. Content type: Short report

    Normal human breast epithelial cells are maintained by the proliferation and differentiation of different human breast epithelial progenitors (HBEPs). However, these progenitor subsets can only be obtained at ...

    Authors: Sumanta Chatterjee, Pratima Basak, Edward Buchel, Leigh C. Murphy and Afshin Raouf

    Citation: Stem Cell Research & Therapy 2018 9:264

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  8. Content type: Review

    With the development of regenerative medicine, a variety of mesenchymal stem cells (MSCs) are increasingly considered for the treatment of premature ovarian failure (POF). Reportedly, bone marrow-derived MSCs ...

    Authors: Yantao He, Dongmei Chen, Lingling Yang, Qiaoni Hou, Huiming Ma and Xian Xu

    Citation: Stem Cell Research & Therapy 2018 9:263

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  9. Content type: Research

    Skeletal muscle regeneration is possible thanks to unipotent stem cells, which are satellite cells connected to the myofibers. Populations of stem cells other than muscle-specific satellite cells are considere...

    Authors: Kamil Kowalski, Matthieu Dos Santos, Pascal Maire, Maria A. Ciemerych and Edyta Brzoska

    Citation: Stem Cell Research & Therapy 2018 9:258

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  10. Content type: Research

    Cell therapy for degenerative diseases aims at rescuing tissue damage by delivery of precursor cells. Thus far, this strategy has been mostly unsuccessful due to massive loss of donor cells shortly after trans...

    Authors: Giuliana Di Rocco, Silvia Baldari, Antonietta Gentile, Maurizio Capogrossi and Gabriele Toietta

    Citation: Stem Cell Research & Therapy 2018 9:250

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  11. Content type: Research

    It is known that, following a physiological insult, bone marrow-derived mesenchymal stem cells (MSCs) mobilize and home to the site of injury. However, the effect of injury on the function of endogenous MSCs i...

    Authors: Ben Antebi, Kerfoot P. Walker III, Arezoo Mohammadipoor, Luis A. Rodriguez, Robbie K. Montgomery, Andriy I. Batchinsky and Leopoldo C. Cancio

    Citation: Stem Cell Research & Therapy 2018 9:251

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  12. Content type: Research

    WNT5A is known to be involved in the pathogenesis of osteoarthritis. This study investigated the molecular mechanism of exosomal miR-92a-3p and WNT5A in chondrogenesis and cartilage degeneration.

    Authors: Guping Mao, Ziji Zhang, Shu Hu, Zhiqi Zhang, Zongkun Chang, Zhiyu Huang, Weiming Liao and Yan Kang

    Citation: Stem Cell Research & Therapy 2018 9:247

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  13. Content type: Research

    Cultivated oral mucosal epithelial cells (OMECs) are widely used in the treatment of limbal stem cell deficiency (LSCD) for their ocular reconstruction capability. As the most important component of the limbal...

    Authors: Xin-Yue Zhao, Hua-Tao Xie, Chao-Ye Duan, Jing Li and Ming-Chang Zhang

    Citation: Stem Cell Research & Therapy 2018 9:256

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  14. Content type: Research

    The increasing number of patients with ovarian insufficiency due to autoimmune disorders, genetic predisposition, or iatrogenic effects of treatment such as cancer therapies necessitates an urgent measure to f...

    Authors: Ashraf Hassanpour, Tahereh Talaei-Khozani, Elias Kargar-Abarghouei, Vahid Razban and Zahra Vojdani

    Citation: Stem Cell Research & Therapy 2018 9:252

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  15. Content type: Research

    Androgen deprivation (AD) as the first-line treatment for advanced prostate cancer (PCa) is insufficient for a long-term effect. Castration resistance remains the greatest obstacle in PCa clinical therapy. Mes...

    Authors: Yang Yu, Qingyun Zhang, Chengzhong Ma, Xue Yang, Rui Lin, Hongxiang Zhang, Yan Liu, Zhipeng Han and Jiwen Cheng

    Citation: Stem Cell Research & Therapy 2018 9:242

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  16. Content type: Research

    Bone marrow mesenchymal stem cells (BMSC) transfer has been attempted as a therapeutic strategy in experimental lung injury and fibrosis. Reduction of neutrophilic infiltration is one of the mechanisms involve...

    Authors: XiaoSan Su, Liu Yang, YanFeng Yin, Jie Huang, Fei Qiao, Yu Fang, Lu Yu, YinYin Wang, KaiHua Zhou and Jun Wang

    Citation: Stem Cell Research & Therapy 2018 9:253

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  17. Content type: Research

    Premature ovarian failure (POF) is a severe complication associated with chemotherapy for female patients of childbearing age. A previous study has shown that bone marrow-derived mesenchymal stem cells (MSCs) ...

    Authors: Xiaoying Chen, Qing Wang, Xinran Li, Qingru Wang, Jiaxin Xie and Xiafei Fu

    Citation: Stem Cell Research & Therapy 2018 9:240

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  18. Content type: Research

    Through recent studies, the onset of acute pancreatitis in pancreatic acinar cells (PACs) and the regulatory role of PACs in severe acute pancreatitis (SAP) have been revealed. During the early stages of pancr...

    Authors: Qiang Li, Woo-Jin Song, Min-Ok Ryu, Aryung Nam, Ju-Hyun An, Jin-Ok Ahn, Dong Ha Bhang, Yun Chan Jung and Hwa-Young Youn

    Citation: Stem Cell Research & Therapy 2018 9:255

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  19. Content type: Research

    This study investigated the therapeutic effects of MSC-derived exosomes (MSC-Exos) on erectile function in a rat model of cavernous nerve injury (CNI).

    Authors: Xi Ouyang, Xiaoyan Han, Zehong Chen, Jiafeng Fang, Xuna Huang and Hongbo Wei

    Citation: Stem Cell Research & Therapy 2018 9:246

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  20. Content type: Review

    Neurodegenerative disorders have a complex pathology and are characterized by a progressive loss of neuronal architecture in the brain or spinal cord. Neuroprotective agents have demonstrated promising results...

    Authors: Syed Shadab Raza, Aurel Popa Wagner, Yawer S. Hussain and Mohsin Ali Khan

    Citation: Stem Cell Research & Therapy 2018 9:245

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  21. Content type: Research

    Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age is the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described t...

    Authors: Nayra Cárdenes, Diana Álvarez, Jacobo Sellarés, Yating Peng, Catherine Corey, Sophie Wecht, Seyed Mehdi Nouraie, Swaroop Shanker, John Sembrat, Marta Bueno, Sruti Shiva, Ana L. Mora and Mauricio Rojas

    Citation: Stem Cell Research & Therapy 2018 9:257

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  22. Content type: Method

    Non-adherent or ultra-low attachment three-dimensional (3D) culture, also called sphere formation assay, has been widely used to assess the malignant phenotype and stemness potential of transformed or cancer c...

    Authors: Weijie Gao, Dinglan Wu, Yuliang Wang, Zhu Wang, Chang Zou, Yong Dai, Chi-Fai Ng, Jeremy Yuen-Chun Teoh and Franky Leung Chan

    Citation: Stem Cell Research & Therapy 2018 9:243

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  23. Content type: Review

    Inducing donor-specific immunological tolerance, which avoids the complications of long-term immunosuppression, is an important goal in organ transplantation. Interleukin-35 (IL-35), a cytokine identified in 2...

    Authors: Hao Guo, Baozhu Li, Wei Wang, Na Zhao and Haopeng Gao

    Citation: Stem Cell Research & Therapy 2018 9:254

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  24. Content type: Research

    Stem cells are increasingly seen as a solution for many health challenges for an ageing population. However, their potential benefits in the clinic are currently curtailed by technical challenges such as high ...

    Authors: Richard Harrison, Hilda Anaid Lugo Leija, Stephanie Strohbuecker, James Crutchley, Sarah Marsh, Chris Denning, Alicia El Haj and Virginie Sottile

    Citation: Stem Cell Research & Therapy 2018 9:248

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  25. Content type: Review

    Aging is a high risk factor for the development of osteoporosis, a multifactorial age-related progressive disease characterized by reduced bone mass and increased risk of fractures. At the cellular level, the ...

    Authors: Arantza Infante and Clara I. Rodríguez

    Citation: Stem Cell Research & Therapy 2018 9:244

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  26. Content type: Commentary

    Amyotrophic lateral sclerosis (ALS) is a fatal paralytic disease with no cure or treatment to stop disease progression. Because ALS represents an urgent unmet medical need, a significant number of therapeutics...

    Authors: Luis Barbeito

    Citation: Stem Cell Research & Therapy 2018 9:241

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    The original article was published in Stem Cell Research & Therapy 2018 9:152

  27. Content type: Research

    In-vitro spermatogenesis in mammalian species is considered an important topic in reproductive biology. New strategies for achieving a complete version of spermatogenesis ex vivo have been conducted using an o...

    Authors: Keykavos Gholami, Gholamreza Pourmand, Morteza Koruji, Sepideh Ashouri and Mehdi Abbasi

    Citation: Stem Cell Research & Therapy 2018 9:249

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  28. Content type: Research

    Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (H2O2). In diabetes, elevated levels of glucose...

    Authors: Y. S. Basmaeil, A. M. Al Subayyil, T. Khatlani, E. Bahattab, M. Al-Alwan, F. M. Abomaray, B. Kalionis, M. A. Alshabibi, A. S. AlAskar and M. H. Abumaree

    Citation: Stem Cell Research & Therapy 2018 9:238

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  29. Content type: Research

    Cell therapy constitutes an attractive alternative to treat stress urinary incontinence. Although promising results have been demonstrated in this field, the procedure requires further optimization. The most c...

    Authors: Anna Burdzinska, Bartosz Dybowski, Weronika Zarychta-Wiśniewska, Agnieszka Kulesza, Marta Butrym, Radoslaw Zagozdzon, Agnieszka Graczyk-Jarzynka, Piotr Radziszewski, Zdzislaw Gajewski and Leszek Paczek

    Citation: Stem Cell Research & Therapy 2018 9:239

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  30. Content type: Research

    Mesenchymal stem cells (MSCs) play an anti-inflammatory role by secreting certain bioactive molecules to exert their therapeutic effects for disease treatment. However, the underlying mechanism of MSCs in chro...

    Authors: Junyu Fan, Xiaojun Tang, Qian Wang, Zhuoya Zhang, Shufang Wu, Wenchao Li, Shanshan Liu, Genhong Yao, Hongwei Chen and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2018 9:237

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  31. Content type: Review

    In this review we present current evidence on the possibility of umbilical cord tissue cryopreservation for subsequent clinical use. Protocols for obtaining umbilical cord-derived vessels, Wharton’s jelly-base...

    Authors: Irina Arutyunyan, Timur Fatkhudinov and Gennady Sukhikh

    Citation: Stem Cell Research & Therapy 2018 9:236

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  32. Content type: Research

    Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of tran...

    Authors: Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, Alberto Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella…

    Citation: Stem Cell Research & Therapy 2018 9:235

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  33. Content type: Research

    In an earlier pilot study with 10 women, we investigated a new approach for therapy of faecal incontinence (FI) due to obstetric trauma, involving ultrasound-guided injection of autologous skeletal muscle-deri...

    Authors: Andrea Frudinger, Rainer Marksteiner, Johann Pfeifer, Eva Margreiter, Johannes Paede and Marco Thurner

    Citation: Stem Cell Research & Therapy 2018 9:233

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  34. Content type: Research

    Periodontal ligament stem cells (PDLSCs) are considered as candidate cells for the regeneration of periodontal and alveolar bone tissues. Antisense to the cerebellar degeneration-related protein 1 transcript (...

    Authors: Xiaobei Li, Yunfei Zheng, Yan Zheng, Yiping Huang, Yixin Zhang, Lingfei Jia and Weiran Li

    Citation: Stem Cell Research & Therapy 2018 9:232

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  35. Content type: Research

    An understanding of the mechanism underlying adipogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) will provide new therapeutic approaches for many diseases, including osteopor...

    Authors: Yangling Wang, Lei Yang, Xiaofeng Liu, Tao Hong, Tao Wang, Aiwu Dong, Jiangxiong Li, Xiaoyuan Xu and Lingling Cao

    Citation: Stem Cell Research & Therapy 2018 9:231

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  36. Content type: Research

    Inner ear hair cells as mechanoreceptors are extremely important for hearing. Defects in hair cells are a major cause of deafness. Induced pluripotent stem cells (iPSCs) are promising for regenerating inner ea...

    Authors: Jianling Chen, Fanfan Hong, Cui Zhang, Liang Li, Cuicui Wang, Haosong Shi, Yong Fu and Jinfu Wang

    Citation: Stem Cell Research & Therapy 2018 9:230

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  37. Content type: Correction

    The original article [1] contained two minor errors affecting the labelling of Fig. 3d and Figs. 6b & 6c; these errors have now been corrected in the respective figures in the original article.

    Authors: Emily R. Moore, Ya Xing Zhu, Han Seul Ryu and Christopher R. Jacobs

    Citation: Stem Cell Research & Therapy 2018 9:229

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    The original article was published in Stem Cell Research & Therapy 2018 9:190

  38. Content type: Review

    Glioma, which accounts for more than 30% of primary central nervous system tumours, is characterised by symptoms such as headaches, epilepsy, and blurred vision. Glioblastoma multiforme is the most aggressive,...

    Authors: Qing Zhang, Wei Xiang, Dong-ye Yi, Bing-zhou Xue, Wan-wan Wen, Ahmed Abdelmaksoud, Nan-xiang Xiong, Xiao-bing Jiang, Hong-yang Zhao and Peng Fu

    Citation: Stem Cell Research & Therapy 2018 9:228

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  39. Content type: Research

    Deep vein thrombosis (DVT) is caused by blood clotting in the deep veins. Thrombosis resolution and recanalization can be accelerated by endothelial progenitor cells. In this report, we investigated the effect...

    Authors: Jiacheng Sun, Zhiwei Zhang, Teng Ma, Ziying Yang, Jinlong Zhang, Xuan Liu, Da Lu, Zhenya Shen, Junjie Yang and Qingyou Meng

    Citation: Stem Cell Research & Therapy 2018 9:223

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  40. Content type: Review

    Acute kidney injury (AKI) remains a worldwide public health issue due to its increasing incidence, significant mortality, and lack of specific target-orientated therapy. Developments in mesenchymal stem cell (...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2018 9:225

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  41. Content type: Research

    Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin 1 (SIRT1) affect cellular NAD+ levels and play essentia...

    Authors: Siyuan Zha, Zhen Li, Qing Cao, Fei Wang and Fang Liu

    Citation: Stem Cell Research & Therapy 2018 9:224

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  42. Content type: Research

    Tooth agenesis, one of the most common developmental anomalies, can affect the function and esthetics of patients. The aim of the present study was to identify genetic clues for familial tooth agenesis and exp...

    Authors: Tianyi Xin, Ting Zhang, Qian Li, Tingting Yu, Yunyan Zhu, Ruili Yang and Yanheng Zhou

    Citation: Stem Cell Research & Therapy 2018 9:221

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  43. Content type: Correction

    The original article [1] contained a small typo affecting the co-author, Mohammed Al-Hawwas’s name. This error has now been corrected.

    Authors: Nimshitha Pavathuparambil Abdul Manaph, Mohammed Al-Hawwas, Larisa Bobrovskaya, Patrick T. Coates and Xin-Fu Zhou

    Citation: Stem Cell Research & Therapy 2018 9:222

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    The original article was published in Stem Cell Research & Therapy 2018 9:189

  44. Content type: Research

    Irradiation-induced kidney damage is inevitable during radiotherapeutic practice, which limits effective radiotherapy doses on tumor treatment. In the present study, the role of mTOR complex 1 (mTORC1) signali...

    Authors: Lijian Shao, Wuping Yang, Rui Xu, Shuqin Zhu, Yanqiu Huang, Huan Li, Xincheng Wu, Mengzhen Yue, Xiaoliang Xiong, Xiaowen Chen, Bohai Kuang, Guangqin Fan, Qingxian Zhu and Huihong Zeng

    Citation: Stem Cell Research & Therapy 2018 9:219

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  45. Content type: Research

    Mesenchymal stromal cell (MSC)-based therapy is a promising strategy for preventing the progression of chronic kidney disease (CKD), with the potential to induce tissue regeneration. In search of the best cell...

    Authors: Cinzia Rota, Marina Morigi, Domenico Cerullo, Martino Introna, Ornella Colpani, Daniela Corna, Chiara Capelli, Ton J. Rabelink, Danielle G. Leuning, Daniela Rottoli, Ariela Benigni, Carlamaria Zoja and Giuseppe Remuzzi

    Citation: Stem Cell Research & Therapy 2018 9:220

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