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  1. Dental pulp stem cells (DPSCs) are a promising cell source in endodontic regeneration and tissue engineering with limited self-renewal and pluripotency capacity. N6-methyladenosine (m6A) is the most prevalent, re...

    Authors: Haiyun Luo, Wenjing Liu, Yanli Zhang, Yeqing Yang, Xiao Jiang, Shiqing Wu and Longquan Shao

    Citation: Stem Cell Research & Therapy 2021 12:159

    Content type: Research

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  2. The aim of this meta-analysis was to evaluate the therapeutic effects of mesenchymal stromal cells (MSCs) versus traditional regimens for induction therapy in kidney transplantation (KT), especially the safety...

    Authors: Lingfei Zhao, Chenxia Hu, Fei Han, Dajin Chen, Jun Cheng, Jianyong Wu, Wenhan Peng and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2021 12:158

    Content type: Research

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  3. As one of the most common chronic diseases in the world, osteoporosis occurs especially in postmenopausal women. Circular RNAs (circRNAs) are emerging as major drivers in human disease. The aim of the present ...

    Authors: Feng Zhi, Yi Ding, Rong Wang, Yujiao Yang, Kaiming Luo and Fei Hua

    Citation: Stem Cell Research & Therapy 2021 12:157

    Content type: Research

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  4. Age-associated lung tissue degeneration is a risk factor for lung injury and exacerbated lung disease. It is also the main risk factor for chronic lung diseases (such as COPD, idiopathic pulmonary fibrosis, ca...

    Authors: Yu-kun Yang, Ye Li, Yan-ying Wang, Guang-ping Ruan, Chuan Tian, Qiang Wang, Huan-yu He, Gao-hong Zhu, Dong Fang, Mao Wang, Xiang-qing Zhu and Xing-hua Pan

    Citation: Stem Cell Research & Therapy 2021 12:156

    Content type: Research

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  5. A new coronavirus respiratory disease (COVID-19) caused by the SARS-CoV-2 virus, surprised the entire world, producing social, economic, and health problems. The COVID-19 triggers a lung infection with a multi...

    Authors: Rodrigo N. Riedel, Antonio Pérez-Pérez, Víctor Sánchez-Margalet, Cecilia L. Varone and Julieta L. Maymó

    Citation: Stem Cell Research & Therapy 2021 12:155

    Content type: Review

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  6. Osthole has a potential therapeutic application for anti-osteoporosis. The present study verified whether osthole downregulates osteoclastogenesis via targeting OPG.

    Authors: Zhen-Xiong Jin, Xin-Yuan Liao, Wei-Wei Da, Yong-Jian Zhao, Xiao-Feng Li and De-Zhi Tang

    Citation: Stem Cell Research & Therapy 2021 12:154

    Content type: Research

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  7. Mesenchymal stem cells (MSCs) have been utilized in treating acute graft-versus-host disease (aGvHD) as they show strong immunosuppressive capacity through the release of various mediators, including immunosup...

    Authors: Weijiang Liu, Na Zhou, Yuanlin Liu, Wei Zhang, Xue Li, Yang Wang, Rongxiu Zheng and Yi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:153

    Content type: Research

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  8. Umbilical cord-derived mesenchymal stem/stromal cells (UC-MSCs) emerge as a perspective for therapeutic use in immune and inflammatory diseases. Indeed, immunomodulatory and anti-inflammatory properties, assoc...

    Authors: Miryam Mebarki, Camille Abadie, Jérôme Larghero and Audrey Cras

    Citation: Stem Cell Research & Therapy 2021 12:152

    Content type: Review

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  9. Chemically strategies to generate hepatic cells from human pluripotent stem cells (hPSCs) for the potential clinical application have been improved. However, producing high quality and large quantities of hepa...

    Authors: Tingcai Pan, Jiawang Tao, Yan Chen, Jiaye Zhang, Anteneh Getachew, Yuanqi Zhuang, Ning Wang, Yingying Xu, Shenglin Tan, Ji Fang, Fan Yang, Xianhua Lin, Kai You, Yi Gao and Yin-xiong Li

    Citation: Stem Cell Research & Therapy 2021 12:151

    Content type: Research

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  10. Little is known about the implications of circRNAs in the effects of melatonin (MEL) on bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoporosis (OP) progression. The aim of our stu...

    Authors: Xudong Wang, Taiqiu Chen, Zhihuai Deng, Wenjie Gao, Tongzhou Liang, Xianjian Qiu, Bo Gao, Zizhao Wu, Jincheng Qiu, Yuanxin Zhu, Yanbo Chen, Zhancheng Liang, Hang Zhou, Caixia Xu, Anjing Liang, Peiqiang Su…

    Citation: Stem Cell Research & Therapy 2021 12:150

    Content type: Research

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  11. Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GP...

    Authors: Shun Ouyang, Yan Li, Xing Wu, Yan Wang, Fanmao Liu, Jianning Zhang, Yumin Qiu, Zhe Zhou, Zhichao Wang, Wenhao Xia and Xiufang Lin

    Citation: Stem Cell Research & Therapy 2021 12:149

    Content type: Research

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  12. Idiopathic pulmonary fibrosis (IPF) is an age-related disease with no cure. Mesenchymal stem cell (MSC)-based therapy has emerged as a novel strategy for IPF treatment. Nevertheless, MSCs derived from patients...

    Authors: Linli Shi, Qian Han, Yimei Hong, Weifeng Li, Gencheng Gong, Jiangyu Cui, Mengmeng Mao, Xiaoting Liang, Bei Hu, Xin Li, Qun Luo and Yuelin Zhang

    Citation: Stem Cell Research & Therapy 2021 12:147

    Content type: Research

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  13. Muscle is severely affected by ischemia/reperfusion injury (IRI). Quiescent satellite cells differentiating into myogenic progenitor cells (MPC) possess a remarkable regenerative potential. We herein establish...

    Authors: Franka Messner, Marco Thurner, Jule Müller, Michael Blumer, Julia Hofmann, Rainer Marksteiner, Sebastien Couillard-Despres, Jakob Troppmair, Dietmar Öfner, Stefan Schneeberger and Theresa Hautz

    Citation: Stem Cell Research & Therapy 2021 12:146

    Content type: Research

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  14. Endothelial progenitor cells (EPCs) are promising candidates for the cellular therapy of peripheral arterial and cardiovascular diseases. However, hitherto there is no specific marker(s) defining precisely EPC...

    Authors: Mohamed Essameldin Abdelgawad, Christophe Desterke, Georges Uzan and Sina Naserian

    Citation: Stem Cell Research & Therapy 2021 12:145

    Content type: Research

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  15. Brain death (BD) has been suggested to induce coronary endothelial dysfunction. Ischemia/reperfusion (IR) injury during heart transplantation may lead to further damage of the endothelium. Previous studies hav...

    Authors: Sevil Korkmaz-Icöz, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamás Radovits, Alex Ali Sayour, Mihály Ruppert, Gábor Veres, Matthias Karck and Gábor Szabó

    Citation: Stem Cell Research & Therapy 2021 12:144

    Content type: Research

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  16. Intervertebral fusion is the most common surgery to treat lumbar degenerative disease (LDD). And the graft material used in the operation is derived from the iliac crest to promote fusion. However, autografts ...

    Authors: Weigang Li, Chunwei Huang, Tian Ma, Jiachen Wang, Wenbin Liu, Jiyuan Yan, Gaohong Sheng, Ruizhuo Zhang, Hua Wu and Chaoxu Liu

    Citation: Stem Cell Research & Therapy 2021 12:143

    Content type: Research

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  17. Dental pulp stem cells (DPSCs) are increasingly being advocated as viable cell sources for regenerative medicine-based therapies. However, significant heterogeneity in DPSC expansion and multi-potency capabili...

    Authors: Nadia Y. A. Alaidaroos, Amr Alraies, Rachel J. Waddington, Alastair J. Sloan and Ryan Moseley

    Citation: Stem Cell Research & Therapy 2021 12:142

    Content type: Research

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  18. As a large capillary network, the human placenta plays an important role throughout pregnancy. Placental vascular development is complex and delicate and involves many types of placental cells, such as trophob...

    Authors: Haiying Ma, Shenglu Jiang, Lili Du, Jinfang Liu, Xiaoyan Xu, Xiaomei Lu, Ling Ma, Hua Zhu, Jun Wei and Yanqiu Yu

    Citation: Stem Cell Research & Therapy 2021 12:141

    Content type: Research

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  19. Mesenchymal stem cells (MSCs) are multipotent cells that show self-renewal, multi-directional differentiation, and paracrine and immune regulation. As a result of these properties, the MSCs have great clinical...

    Authors: Wanhao Yan, Shu Diao and Zhipeng Fan

    Citation: Stem Cell Research & Therapy 2021 12:140

    Content type: Review

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  20. Clinical transplants of hematopoietic stem cells (HSC) can provide a lifesaving therapy for many hematological diseases; however, therapeutic applications are hampered by donor availability. In vivo, HSC exist in...

    Authors: Kyle Lewis, Momoko Yoshimoto and Takanori Takebe

    Citation: Stem Cell Research & Therapy 2021 12:139

    Content type: Review

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  21. Mesenchymal stem cells (MSCs) exhibit active abilities to suppress or modulate deleterious immune responses by various molecular mechanisms. These cells are the subject of major translational efforts as cellul...

    Authors: Yi Yu, Alejandra Vargas Valderrama, Zhongchao Han, Georges Uzan, Sina Naserian and Estelle Oberlin

    Citation: Stem Cell Research & Therapy 2021 12:138

    Content type: Research

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  22. Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enabl...

    Authors: Reinhard Dolp, Gertraud Eylert, Christopher Auger, Ayesha Aijaz, Yufei Andy Chen, Saeid Amini-Nik, Alexandra Parousis, Andrea-Kaye Datu and Marc G. Jeschke

    Citation: Stem Cell Research & Therapy 2021 12:137

    Content type: Research

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  23. This arcticle has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13287-016-0438-5.

    Authors: Lihui Yu, Ying Lu, Xiaocui Han, Wenyue Zhao, Jiazhi Li, Jun Mao, Bo Wang, Jie Shen, Shujun Fan, Lu Wang, Mei Wang, Lianhong Li, Jianwu Tang and Bo Song

    Citation: Stem Cell Research & Therapy 2021 12:136

    Content type: Retraction Note

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    The original article was published in Stem Cell Research & Therapy 2016 7:180

  24. Authors: Virginie Neirinckx, Gulistan Agirman, Cécile Coste, Alice Marquet, Valérie Dion, Bernard Rogister, Rachelle Franzen and Sabine Wislet

    Citation: Stem Cell Research & Therapy 2021 12:135

    Content type: Editor's Note

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    The Research to this article has been published in Stem Cell Research & Therapy 2015 6:211

  25. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yifeng Ke, Xiaoe Fan, Rui Hao, Lijie Dong, Min Xue, Liangzhang Tan, Chunbo Yang, Xiaorong Li and Xinjun Ren

    Citation: Stem Cell Research & Therapy 2021 12:134

    Content type: Correction

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    The original article was published in Stem Cell Research & Therapy 2021 12:21

  26. The purpose of this study was to investigate the therapeutic effects of genetically modified mesenchymal stem cells (MSCs) in the treatment of type 2 diabetes mellitus (T2DM) in order to identify a new method ...

    Authors: Binghua Xue, Xiuxiao Xiao, Tingting Yu, Xinhua Xiao, Jing Xie, Qiuhe Ji, Li Wang, Tao Na, Shufang Meng, Lingjia Qian and Haifeng Duan

    Citation: Stem Cell Research & Therapy 2021 12:133

    Content type: Research

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  27. Bone morphogenetic protein 2 (BMP2) is a promising chondrogenic growth factor for cartilage tissue-engineering, but it also induces robust endochondral ossification. Human synovial-derived mesenchymal stromal ...

    Authors: Pengcheng Xiao, Zhenglin Zhu, Chengcheng Du, Yongsheng Zeng, Junyi Liao, Qiang Cheng, Hong Chen, Chen Zhao and Wei Huang

    Citation: Stem Cell Research & Therapy 2021 12:132

    Content type: Research

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  28. Duchenne muscular dystrophy (DMD) is caused by mutations of the gene that encodes the protein dystrophin. A loss of dystrophin leads to severe and progressive muscle wasting in both skeletal and heart muscles....

    Authors: Wanling Xuan, Mahmood Khan and Muhammad Ashraf

    Citation: Stem Cell Research & Therapy 2021 12:131

    Content type: Research

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  29. Thin endometrium adversely affects reproductive success rates with fertility treatment. Autologous transplantation of exogenously prepared endometrium can be a promising therapeutic option for thin endometrium...

    Authors: Ryo Yokomizo, Yukiko Fujiki, Harue Kishigami, Hiroshi Kishi, Tohru Kiyono, Sanae Nakayama, Haruhiko Sago, Aikou Okamoto and Akihiro Umezawa

    Citation: Stem Cell Research & Therapy 2021 12:130

    Content type: Research

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  30. The repair of large-scale full-thickness skin defects represents a challenging obstacle in skin tissue engineering. To address the most important problem in skin defect repair, namely insufficient blood supply...

    Authors: Shuang Lin, Xiaoning He and Yuanjia He

    Citation: Stem Cell Research & Therapy 2021 12:129

    Content type: Research

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  31. Recently, growing evidence has indicated an important role of the complement system, a crucial component of immunity, in mediating neuroinflammation and promoting neuronal apoptosis following closed head injur...

    Authors: Mou Gao, Qin Dong, Wenjia Wang, Zhijun Yang, Lili Guo, Yingzhou Lu, Boyun Ding, Lihua Chen, Jianning Zhang and Ruxiang Xu

    Citation: Stem Cell Research & Therapy 2021 12:128

    Content type: Research

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  32. Extracellular vesicles (EVs) produced by human bone marrow-derived mesenchymal stromal cells (hBM-MSCs) are currently investigated for their clinical effectiveness towards immune-mediated diseases. The large a...

    Authors: Jonathan Gobin, Gauri Muradia, Jelica Mehic, Carole Westwood, Lauren Couvrette, Andrew Stalker, Stewart Bigelow, Christian C. Luebbert, Frédéric St-Denis Bissonnette, Michael J. W. Johnston, Simon Sauvé, Roger Y. Tam, Lisheng Wang, Michael Rosu-Myles and Jessie R. Lavoie

    Citation: Stem Cell Research & Therapy 2021 12:127

    Content type: Research

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  33. Cancer is a leading cause of death in both developed and developing countries, and because of population growth and aging, it is a growing medical burden worldwide. With robust development in medicine, the use...

    Authors: Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Hakimeh Zali and Hassan Niknejad

    Citation: Stem Cell Research & Therapy 2021 12:126

    Content type: Review

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  34. Stroke serves as a prevalent cerebrovascular disorder with severe cerebral ischemia/reperfusion (CIR) injury, in which neural stem cells (NSCs) play critical roles in the recovery of cerebral function. Circula...

    Authors: Bo Yang, Li’e Zang, Jingwen Cui and Linlin Wei

    Citation: Stem Cell Research & Therapy 2021 12:125

    Content type: Research

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  35. Mesenchymal stromal cells (MSCs) constitute one of the cell types most frequently used in cell therapy. Although several studies have shown the efficacy of these cells to modulate inflammation in different ani...

    Authors: Rosario Hervás-Salcedo, María Fernández-García, Miriam Hernando-Rodríguez, Oscar Quintana-Bustamante, Jose-Carlos Segovia, Marcio Alvarez-Silva, Mariano García-Arranz, Pablo Minguez, Victoria del Pozo, Marta Rodríguez de Alba, Damián García-Olmo, Carmen Ayuso, María Luisa Lamana, Juan A. Bueren and Rosa María Yañez

    Citation: Stem Cell Research & Therapy 2021 12:124

    Content type: Research

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  36. To repair bone defects, a variety of bone substitution materials have been used, such as ceramics, metals, natural and synthetic polymers, and combinations thereof. In recent decades, a wide range of synthetic...

    Authors: Siyi Wang, Rong Li, Dandan Xia, Xiao Zhao, Yuan Zhu, Ranli Gu, Jungmin Yoon and Yunsong Liu

    Citation: Stem Cell Research & Therapy 2021 12:123

    Content type: Review

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  37. This research is the first to produce induced pluripotent stem cell-derived inner ear sensory neurons in the Neurog1+/− heterozygote mouse using blastocyst complementation. Additionally, this approach corrected n...

    Authors: Aleta R. Steevens, Matthew W. Griesbach, Yun You, James R. Dutton, Walter C. Low and Peter A. Santi

    Citation: Stem Cell Research & Therapy 2021 12:122

    Content type: Short report

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  38. Diabetic osteoporosis (DOP) is a systemic metabolic bone disease caused by diabetes mellitus (DM). Adipose-derived stem cells (ASCs) play an important role in bone regeneration. Our previous study confirmed th...

    Authors: Shuanglin Peng, Sirong Shi, Gang Tao, Yanjing Li, Dexuan Xiao, Lang Wang, Qing He, Xiaoxiao Cai and Jingang Xiao

    Citation: Stem Cell Research & Therapy 2021 12:120

    Content type: Research

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  39. Tumor-associated antigens (TAAs) can be targeted in cancer therapy. We previously identified a monoclonal antibody (mAb) 12C7, which presented anti-tumor activity in lung cancer stem cells (LCSCs). Here, we ai...

    Authors: Xiong Shu, Kai-Yue Cao, Hui-Qi Liu, Long Yu, Li-Xin Sun, Zhi-Hua Yang, Cheng-Ai Wu and Yu-Liang Ran

    Citation: Stem Cell Research & Therapy 2021 12:119

    Content type: Research

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  40. Oligovascular niche mediates interactions between cerebral endothelial cells and oligodendrocyte precursor cells (OPCs). Disruption of OPC-endothelium trophic coupling may aggravate the progress of cerebral wh...

    Authors: Ning Zhou, Lei Wang, Ping Fu, Zihao Cui, Yuhang Ge, Feiyu Jiang, Jing Liu, Chao Ren, Zuo Luan, Hongbin Fan and Ruiqin Yao

    Citation: Stem Cell Research & Therapy 2021 12:118

    Content type: Research

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  41. Although exosomes, as byproducts of human umbilical cord mesenchymal stem cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal cord injury (SCI), their mechanism of action r...

    Authors: Yang Wang, Xunwei Lai, Depeng Wu, Bin Liu, Nanxiang Wang and Limin Rong

    Citation: Stem Cell Research & Therapy 2021 12:117

    Content type: Research

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  42. Combination of mesenchymal stem cells (MSCs) and biomaterials is a rapidly growing approach in regenerative medicine particularly for chronic degenerative disorders including osteoarthritis and osteoporosis. T...

    Authors: Mohamed I. Elashry, Nadine Baulig, Alena-Svenja Wagner, Michele C. Klymiuk, Benjamin Kruppke, Thomas Hanke, Sabine Wenisch and Stefan Arnhold

    Citation: Stem Cell Research & Therapy 2021 12:116

    Content type: Research

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  43. Mesenchymal stem cells (MSCs) are favourable treatments for ischaemic diseases; however, MSCs from diabetic patients are not useful for this purpose. Recent studies have shown that the expression of miR-34a is...

    Authors: Fengyun Zhang, Fei Gao, Kun Wang, Xiaohong Liu and Zhuoqi Zhang

    Citation: Stem Cell Research & Therapy 2021 12:115

    Content type: Research

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  44. Retarded wound healing in patients with obesity contributes to a risk of complications associated with vascular insufficiency and oxidative stress. The high cholesterol levels of patients with obesity are asso...

    Authors: Jun Sung Kim, Young Hyun Jung, Hyun Jik Lee, Chang Woo Chae, Gee Euhn Choi, Jae Ryong Lim, Seo Yihl Kim, Joo Eun Lee and Ho Jae Han

    Citation: Stem Cell Research & Therapy 2021 12:114

    Content type: Research

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  45. Despite recent rapid progress in method development and biological understanding of induced pluripotent stem (iPS) cells, there has been a relative shortage of tools that monitor the early reprogramming proces...

    Authors: Sandhya Sriram, Nam-Young Kang, Subha Subramanian, Tannistha Nandi, Samydurai Sudhagar, Qiaorui Xing, Gerine Jin-Ling Tong, Allen Kuan-Liang Chen, Thekkeparambil Chandrabose Srijaya, Patrick Tan, Yuin-Han Loh, Young-Tae Chang and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2021 12:113

    Content type: Method

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  46. Nicotinamide phosphoribosyltransferase (NAMPT) regulates cellular functions through the protein deacetylation activity of nicotinamide adenine dinucleotide (NAD+)-dependent sirtuins (SIRTs). SIRTs regulate functi...

    Authors: Yun Xu, Masoud Nasri, Benjamin Dannenmann, Perihan Mir, Azadeh Zahabi, Karl Welte, Tatsuya Morishima and Julia Skokowa

    Citation: Stem Cell Research & Therapy 2021 12:112

    Content type: Research

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  47. Cerebral ischemia-reperfusion (I/R) injury, the most common form of stroke, has high mortality and often brings persistent and serious brain dysfunction among survivors. Administration of adipose-derived mesen...

    Authors: Yamei Zhang, Junying Liu, Mi Su, Xin Wang and Chenchen Xie

    Citation: Stem Cell Research & Therapy 2021 12:111

    Content type: Research

    Published on:

  48. Multipotent mesenchymal stromal cells (MSCs) are potentially therapeutic for muscle disease because they can accumulate at the sites of injury and act as immunosuppressants. MSCs are attractive candidates for ...

    Authors: Yuko Nitahara-Kasahara, Mutsuki Kuraoka, Yuki Oda, Hiromi Hayashita-Kinoh, Shin’ichi Takeda and Takashi Okada

    Citation: Stem Cell Research & Therapy 2021 12:105

    Content type: Research

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