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  1. Content type: Research

    Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Her...

    Authors: Cajsa Davegårdh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, Bente Klarlund Pedersen, Camilla Scheele and Charlotte Ling

    Citation: Stem Cell Research & Therapy 2019 10:26

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  2. Content type: Research

    Patients with diabetes mellitus (DM) often suffered with many musculoskeletal disorders, such as tendon rupture and tendinopathy. However, the understanding of the pathogenesis of these alternations is limited...

    Authors: Liu SHI, Ying-juan LI, Guang-chun DAI, Yu-cheng LIN, Gang LI, Chen WANG, Hui CHEN and Yun-feng RUI

    Citation: Stem Cell Research & Therapy 2019 10:27

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  3. Content type: Research

    Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by OCT4. p21, a gene negatively associated with self-re...

    Authors: Yan Lu, Huinan Qu, Da Qi, Wenhong Xu, Shutong Liu, Xiangshu Jin, Peiye Song, Yantong Guo, Yiyang Jia, Xinqi Wang, Hairi Li, Yulin Li and Chengshi Quan

    Citation: Stem Cell Research & Therapy 2019 10:28

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  4. Content type: Research

    Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by ra...

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou

    Citation: Stem Cell Research & Therapy 2019 10:30

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  5. Content type: Research

    Fully understanding the developmental process of hepatic stem cells (HSCs) and the mechanisms of their committed differentiation is essential for optimizing the generation of functional hepatocytes for cell th...

    Authors: Jiefang Huang, Xiaonan Zhao, Jian Wang, Yiji Cheng, Qiong Wu, Bei Wang, Fang Zhao, Lijun Meng, Yanyun Zhang, Min Jin and Huanbai Xu

    Citation: Stem Cell Research & Therapy 2019 10:31

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  6. Content type: Short report

    Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this st...

    Authors: Simona Ruggieri, Luigi Viggiano, Tiziana Annese, Carmela Rubolino, Andrea Gerbino, Roberta De Zio, Patrizia Corsi, Roberto Tamma, Domenico Ribatti, Mariella Errede, Francesca Operto, Lucia Margari, Nicoletta Resta, Silvia Di Tommaso, Jessica Rosati, Maria Trojano…

    Citation: Stem Cell Research & Therapy 2019 10:29

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  7. Content type: Research

    Human mesenchymal stem cells are a strong candidate for cell therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity. Yet, their scarcity, limited expansion...

    Authors: Madison McGrath, Edmund Tam, Martina Sladkova, Athbah AlManaie, Matthew Zimmer and Giuseppe Maria de Peppo

    Citation: Stem Cell Research & Therapy 2019 10:11

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  8. Content type: Research

    Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research e...

    Authors: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson and Alicia J. El Haj

    Citation: Stem Cell Research & Therapy 2019 10:25

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  9. Content type: Research

    Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that...

    Authors: Yanzhen Bi, Jiannan Li, Yonghong Yang, Quanyi Wang, Quanquan Wang, Xiaobei Zhang, Guanjun Dong, Yibo Wang, Zhongping Duan, Zhenfeng Shu, Tongjun Liu, Yu Chen, Kai Zhang and Feng Hong

    Citation: Stem Cell Research & Therapy 2019 10:22

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  10. Content type: Research

    Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-M...

    Authors: Xiao-Yu Luo, Xiang-Jun Meng, Da-Chun Cao, Wei Wang, Kun Zhou, Lei Li, Mei Guo and Ping Wang

    Citation: Stem Cell Research & Therapy 2019 10:16

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  11. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary dependi...

    Authors: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi and Changshun Shao

    Citation: Stem Cell Research & Therapy 2019 10:18

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  12. Content type: Research

    Distraction osteogenesis (DO) is an effective but lengthy procedure to fully induce bone regeneration in large bone defects. Accumulating evidence supports the role of exosomes secreted by endothelial progenit...

    Authors: Yachao Jia, Yu Zhu, Shuo Qiu, Jia Xu and Yimin Chai

    Citation: Stem Cell Research & Therapy 2019 10:12

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  13. Content type: Research

    Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or in...

    Authors: Suhyun Park, Seon In Hwang, Jonghun Kim, Seoyeon Hwang, Sohee Kang, Sera Yang, Jonghwa Kim, Wonseok Kang, Kyun-Hwan Kim, Dong Wook Han and Yong-Han Paik

    Citation: Stem Cell Research & Therapy 2019 10:21

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  14. Content type: Research

    Cell therapy remains the most promising approach against ischemic heart injury. However, poor survival of engrafted cells in ischemic sites diminishes its therapeutic efficacy. Follistatin-like 1 (Fstl1) is do...

    Authors: Han Shen, Guanghao Cui, Yanqiong Li, Wenxue Ye, Yimin Sun, Zihan Zhang, Jingjing Li, Guiying Xu, Xiansheng Zeng, Yanxia Zhang, Wencheng Zhang, Zan Huang, Weiqian Chen and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2019 10:17

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  15. Content type: Research

    Mesenchymal stem cells (MSCs) have emerged as a promising regenerative tool, owing mainly to their multi-differentiation potential and immunosuppressive capacity. When compared with MSCs classically derived fr...

    Authors: Jiao Ma, Jun Wu, Lei Han, Xiangxiang Jiang, Long Yan, Jie Hao and Hongmei Wang

    Citation: Stem Cell Research & Therapy 2019 10:19

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  16. Content type: Research

    Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach a...

    Authors: Tianyue Pan, Hao Liu, Yuan Fang, Zheng Wei, Shiyang Gu, Gang Fang, Yifan Liu, Yang Luo, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi…

    Citation: Stem Cell Research & Therapy 2019 10:15

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  17. Content type: Research

    The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood.

    Authors: Alexandra Calle, Soraya López-Martín, Marta Monguió-Tortajada, Francesc Enric Borràs, María Yáñez-Mó and Miguel Ángel Ramírez

    Citation: Stem Cell Research & Therapy 2019 10:23

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  18. Content type: Research

    Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese m...

    Authors: Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun and Xiaobo Sun

    Citation: Stem Cell Research & Therapy 2019 10:20

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  19. Content type: Research

    Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of...

    Authors: Chen Kan, Na Ding, Jiazhao Yang, Zhenya Tan, Tammy L. McGuire, Haimei Lu, Keqin Zhang, Diana M. Palila Berger, John A. Kessler and Lixin Kan

    Citation: Stem Cell Research & Therapy 2019 10:14

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  20. Content type: Research

    Although mesenchymal stem/stromal cell (MSC) chondrogenic differentiation has been thoroughly investigated, the rudiments for enhancing chondrogenesis have remained largely dependent on external cues. Focus to...

    Authors: Melika Sarem, Oliver Otto, Simon Tanaka and V. Prasad Shastri

    Citation: Stem Cell Research & Therapy 2019 10:10

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  21. Content type: Research

    Mouse somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors known to regulate pluripotency, including Oct4, Sox2, Klf4, and c-Myc. It has been reported that Sirtuin 6...

    Authors: Peng Xu, Ting-ting Wang, Xiu-zhen Liu, Nan-Yu Wang, Li-hong Sun, Zhu-qin Zhang, Hou-zao Chen, Xiang Lv, Yue Huang and De-Pei Liu

    Citation: Stem Cell Research & Therapy 2019 10:9

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  22. Content type: Research

    The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research interest. A renewable source of brown adipocyte (BA) proge...

    Authors: Michael D. West, Ching-Fang Chang, Dana Larocca, Jie Li, Jianjie Jiang, Pamela Sim, Ivan Labat, Karen B. Chapman, Kari E. Wong, James Nicoll, Michael J. Van Kanegan, Aubrey D. N. J. de Grey, Igor O. Nasonkin, Andreas Stahl and Hal Sternberg

    Citation: Stem Cell Research & Therapy 2019 10:7

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  23. Content type: Correction

    The original article [1] contained errors in the presentation of Figure 7.

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang

    Citation: Stem Cell Research & Therapy 2019 10:6

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    The original article was published in Stem Cell Research & Therapy 2018 9:339

  24. Content type: Research

    The etiology and pathology osteonecrosis of the femoral head (ONFH) are not completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis factor alpha (TNFα) has been shown to be i...

    Authors: Bin Fang, Ding Wang, Jiaqian Zheng, Qiushi Wei, Dongxiang Zhan, Yamei Liu, Xuesong Yang, Haibin Wang, Gang Li, Wei He and Liangliang Xu

    Citation: Stem Cell Research & Therapy 2019 10:5

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  25. Content type: Research

    Hertwig’s epithelial root sheath (HERS) is important in guiding tooth root formation by differentiating into cementoblasts through epithelial–mesenchymal transition (EMT) and inducing odontoblastic differentia...

    Authors: Xuebing Li, Sicheng Zhang, Zirui Zhang, Weihua Guo, Guoqing Chen and Weidong Tian

    Citation: Stem Cell Research & Therapy 2019 10:3

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  26. Content type: Research

    To explore the effect of mesenchymal stem cells isolated from menstrual blood (MB-MSCs) on epirubicin-induced damage to human ovarian granulosa cells (GCs) and its potential mechanisms.

    Authors: Zhongrui Yan, Fengyi Guo, Qing Yuan, Yu Shao, Yedan Zhang, Huiyan Wang, Shaohua Hao and Xue Du

    Citation: Stem Cell Research & Therapy 2019 10:4

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  27. Content type: Research

    Tendon stem/progenitor cells (TSPC) exhibit a low proliferative response to heal tendon injury, leading to limited regeneration outcomes. Exogenous growth factors that activate TSPC proliferation have emerged ...

    Authors: Tsung-Chuan Ho, Shawn H. Tsai, Shu-I Yeh, Show-Li Chen, Kwang-Yi Tung, Hsin-Yu Chien, Yung-Chang Lu, Chang-Hung Huang and Yeou-Ping Tsao

    Citation: Stem Cell Research & Therapy 2019 10:2

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  28. Content type: Research

    Heart failure has become a global health problem with increasing incidences worldwide. Traditional pharmacological treatments can delay but cannot reverse the underlying disease processes. The clinical applica...

    Authors: Fei Zhang, Yuan Xie and Yuhao Bian

    Citation: Stem Cell Research & Therapy 2018 9:358

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  29. Content type: Review

    Human embryonic stem cells (hESC) and induced pluripotent stem cells (hiPSC) are considered attractive sources of pancreatic β cells and islet organoids. Recently, several reports presented that hESC/iPSC-deri...

    Authors: Hussain Md. Shahjalal, Ahmed Abdal Dayem, Kyung Min Lim, Tak-il Jeon and Ssang-Goo Cho

    Citation: Stem Cell Research & Therapy 2018 9:355

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  30. Content type: Research

    Methotrexate (MTX) is widely used for the treatment of rheumatoid arthritis (RA). The drug is cost-effective, but sometimes causes hepatotoxicity, requiring a physician’s attention. In this study, we simulated...

    Authors: Juryun Kim, Yena Kim, Jinhyeok Choi, Hyerin Jung, Kijun Lee, Jaewoo Kang, Narae Park, Yeri Alice Rim, Yoojun Nam and Ji Hyeon Ju

    Citation: Stem Cell Research & Therapy 2018 9:357

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  31. Content type: Research

    Bone marrow mesenchymal stem cells (BMSCs) can provide an additional source of therapeutic stem cells for regeneration of liver cells during acute liver injury (ALI). However, the insufficient hepatic homing b...

    Authors: Ting Sun, Feng Gao, Xin Li, Yingyu Cai, Min Bai, Fan Li and Lianfang Du

    Citation: Stem Cell Research & Therapy 2018 9:356

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  32. Content type: Retraction Note

    This article [1] has been retracted by the authors because, contrary to the statement in the article, ethical approval was not obtained to conduct this study.

    Authors: Ihn Han, Miyong Yun, Eun-Ok Kim, Bonglee Kim, Min-Hyung Jung and Sung-Hoon Kim

    Citation: Stem Cell Research & Therapy 2018 9:354

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    The original article was published in Stem Cell Research & Therapy 2014 5:54

  33. Content type: Research

    Adipose tissue is an excellent source for isolation of stem cells for treating various clinical conditions including injuries to the neuromuscular system. Many previous studies have focused on differentiating ...

    Authors: R. El-Habta, M. Sloniecka, P. J. Kingham and L. J. Backman

    Citation: Stem Cell Research & Therapy 2018 9:352

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  34. Content type: Short report

    A 27-year-old male with HIV-associated naïve and high-risk Burkitt’s lymphoma sequentially received short-term, high-dose non-myeloablative chemotherapy and autologous CD34-positive stem cell transfusion in th...

    Authors: Haiyan Min, Jianwei Yang, Sanbin Wang, Pengfei Tao, Yuqin Song, Xiaopei Wang, Huiqin Li, Xinping Yang, Xingqi Dong, Fu-Sheng Wang, Ming Shi, Xicheng Wang and Ruonan Xu

    Citation: Stem Cell Research & Therapy 2018 9:353

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  35. Content type: Research

    Human bone marrow-derived mesenchymal stem/stromal cells (hBM MSCs) have multiple functions, critical for skeletal formation and function. Their functional heterogeneity, however, represents a major challenge ...

    Authors: Alison T. Merryweather-Clarke, David Cook, Barbara Joo Lara, Peng Hua, Emmanouela Repapi, Neil Ashley, Shiang Y. Lim and Suzanne M. Watt

    Citation: Stem Cell Research & Therapy 2018 9:351

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  36. Content type: Review

    The discovery of animal cloning and subsequent development of cell reprogramming technology were quantum leaps as they led to the achievement of rejuvenation by cell reprogramming and the emerging view that ag...

    Authors: Rodolfo G. Goya, Marianne Lehmann, Priscila Chiavellini, Martina Canatelli-Mallat, Claudia B. Hereñú and Oscar A. Brown

    Citation: Stem Cell Research & Therapy 2018 9:349

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  37. Content type: Research

    Ischemic vascular diseases are the major cause of death worldwide. In recent years, endothelial cell (EC)-based approaches to vascular regeneration are increasingly viable strategies for treating ischemic dise...

    Authors: Fuyi Cheng, Yujing Zhang, Yuan Wang, Qingyuan Jiang, Cheng jian Zhao, Jie Deng, Xiaolei Chen, Yunqi Yao, Zhemin Xia, Lin Cheng, Lei Dai, Gang Shi, Yang Yang, Shuang Zhang, Dechao Yu, Yuquan Wei…

    Citation: Stem Cell Research & Therapy 2018 9:350

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  38. Content type: Research

    This study was aimed to investigate the role and specific molecular mechanism of HIF1A-AS2/miR-665/IL6 axis in regulating osteogenic differentiation of adipose-derived stem cells (ASCs) via the PI3K/Akt signal...

    Authors: Ruoyu Wu, Jihao Ruan, Yongjin Sun, Mengyu Liu, Zhuang Sha, Cunyi Fan and Qingkai Wu

    Citation: Stem Cell Research & Therapy 2018 9:348

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  39. Content type: Research

    Millions of people are affected with retinal diseases that eventually cause blindness, and retinal progenitor cell (RPC) transplantation is a promising therapeutic avenue. However, RPC expansion and the underl...

    Authors: Caixia Jin, Qingjian Ou, Zongyi Li, Juan Wang, Jieping Zhang, Haibin Tian, Jing-Ying Xu, Furong Gao, Lixia Lu and Guo-Tong Xu

    Citation: Stem Cell Research & Therapy 2018 9:346

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  40. Content type: Research

    Renal ischemia–reperfusion (I/R) injury is a major cause of acute kidney injury (AKI), which is associated with high morbidity and mortality. AKI is a serious and costly medical condition. Effective therapy fo...

    Authors: Wen-Ching Shen, Yu-Hsiang Chou, Hsiang-Po Huang, Jenn-Feng Sheen, Shih-Chieh Hung and Hsin-Fu Chen

    Citation: Stem Cell Research & Therapy 2018 9:344

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  41. Content type: Research

    Basic fibroblast growth factor (bFGF) regulates maintenance of stemness and modulation of osteo/odontogenic differentiation and mineralization in stem cells from human exfoliated deciduous teeth (SHEDs). Miner...

    Authors: Nunthawan Nowwarote, Waleerat Sukarawan, Prasit Pavasant, Brian L. Foster and Thanaphum Osathanon

    Citation: Stem Cell Research & Therapy 2018 9:345

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  42. Content type: Research

    Apelin plays a key beneficial role in energy metabolism by increasing glucose uptake and insulin sensitivity; however, apelin has a short half-life because it is rapidly cleared from the circulation limiting i...

    Authors: Lian Ru Gao, Ning Kun Zhang, Yan Zhang, Yu Chen, Li Wang, Ying Zhu and Hai Hong Tang

    Citation: Stem Cell Research & Therapy 2018 9:339

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    The Correction to this article has been published in Stem Cell Research & Therapy 2019 10:6

  43. Content type: Research

    Three-dimensional (3D) floating culture clumps of mesenchymal stem cell (MSC)/extracellular matrix (ECM) complexes (C-MSCs) consist of cells and self-produced ECM. Previous studies have demonstrated that C-MSC...

    Authors: Nao Komatsu, Mikihito Kajiya, Souta Motoike, Manabu Takewaki, Susumu Horikoshi, Tomoyuki Iwata, Kazuhisa Ouhara, Katsuhiro Takeda, Shinji Matsuda, Tsuyoshi Fujita and Hidemi Kurihara

    Citation: Stem Cell Research & Therapy 2018 9:342

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  44. Content type: Review

    Mesenchymal stem cells (MSC) comprise a heterogeneous population of rapidly proliferating cells that can be isolated from adult (e.g., bone marrow, adipose tissue) as well as fetal (e.g., umbilical cord) tissu...

    Authors: Ioannis Christodoulou, Maria Goulielmaki, Marina Devetzi, Mihalis Panagiotidis, Georgios Koliakos and Vassilis Zoumpourlis

    Citation: Stem Cell Research & Therapy 2018 9:336

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  45. Content type: Research

    Despite considerable progress in the development of methods for hematopoietic differentiation, efficient generation of transplantable hematopoietic stem cells (HSCs) and other genuine functional blood cells fr...

    Authors: Mengge Wang, Hongtao Wang, Yuqi Wen, Xiaoyuan Chen, Xin Liu, Jie Gao, Pei Su, Yuanfu Xu, Wen Zhou, Lihong Shi and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2018 9:340

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