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  1. Significant developments in stem cell therapy for Parkinson’s disease (PD) have already been achieved; however, methods for reliable assessment of dopamine neuron maturation in vivo are lacking. Establishing t...

    Authors: Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee…

    Citation: Stem Cell Research & Therapy 2020 11:347

    Content type: Research

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  2. Research into the pathogenesis of endometriosis (EMs) would substantially promote its effective treatment and early diagnosis. However, the aetiology of EMs is poorly understood and controversial despite the p...

    Authors: Yanli Liu, Shengying Liang, Fen Yang, Yuliang Sun, Lidan Niu, Yakun Ren, Hongmei Wang, Yanan He, Jiang Du, Jun Yang and Juntang Lin

    Citation: Stem Cell Research & Therapy 2020 11:346

    Content type: Research

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  3. Mesenchymal stromal cells (MSCs) are a subset of heterogeneous non-hematopoietic fibroblast-like cells that can differentiate into cells of multiple lineages, such as chondrocytes, osteoblasts, adipocytes, myo...

    Authors: Xiaomo Wu, Ju Jiang, Zhongkai Gu, Jinyan Zhang, Yang Chen and Xiaolong Liu

    Citation: Stem Cell Research & Therapy 2020 11:345

    Content type: Review

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  4. Full-thickness wounds severely affect patients’ life quality and become challenging problems for clinicians. Stem cells have great prospects in the treatment of wounds. Our previous study confirmed that autolo...

    Authors: Shaobin Huang, Zhicheng Hu, Peng Wang, Yi Zhang, Xiaoling Cao, Yunxian Dong, Pu Cheng, Hailin Xu, Wenkai Zhu, Bing Tang and Jiayuan Zhu

    Citation: Stem Cell Research & Therapy 2020 11:344

    Content type: Research

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  5. Inadequate vascularization is a challenge in bone tissue engineering because internal cells are prone to necrosis due to a lack of nutrient supply. Rat bone marrow-derived mesenchymal stem cells (rBMSCs) and h...

    Authors: Miaomiao Chai, Ce Gu, Qihua Shen, Jiaxing Liu, Yi Zhou, Ziyang Jin, Wanli Xiong, Yan Zhou and Wensong Tan

    Citation: Stem Cell Research & Therapy 2020 11:343

    Content type: Research

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  6. Differentiation of mouse trophoblast stem cells (TSCs) to trophoblast giant cells (TGCs) has been widely used as a model system to study placental development and function. While several differentially express...

    Authors: Rahim Ullah, Ambreen Naz, Hafiza Sara Akram, Zakir Ullah, Muhammad Tariq, Aziz Mithani and Amir Faisal

    Citation: Stem Cell Research & Therapy 2020 11:342

    Content type: Research

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  7. The skeletal muscle regeneration relays on the satellite cells which are stem cells located between basal lamina and plasmalemma of muscle fiber. In the injured muscles, the satellite cells become activated, s...

    Authors: Bartosz Mierzejewski, Iwona Grabowska, Daniel Jackowski, Aliksandra Irhashava, Zuzanna Michalska, Władysława Stremińska, Katarzyna Jańczyk-Ilach, Maria Anna Ciemerych and Edyta Brzoska

    Citation: Stem Cell Research & Therapy 2020 11:341

    Content type: Research

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  8. In the clinical study by Le Thi Bich et al., allogeneic expanded umbilical cord-derived mesenchymal stem cells (UC-MSCs) were intravenously infused to treat patients with chronic obstructive pulmonary disease ...

    Authors: Talita Stessuk and João Tadeu Ribeiro-Paes

    Citation: Stem Cell Research & Therapy 2020 11:340

    Content type: Commentary

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    The original article was published in Stem Cell Research & Therapy 2020 11:60

  9. It has been reported that the high-dosage administration of domestically approved pharmaceutical drugs, especially granulocyte colony-stimulating factor (G-CSF) and romiplostim (RP), is a rapid and appropriate...

    Authors: Masaru Yamaguchi, Marino Suzuki, Moeri Funaba, Akane Chiba and Ikuo Kashiwakura

    Citation: Stem Cell Research & Therapy 2020 11:339

    Content type: Research

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  10. The repair of critical-sized bone defect represents a challenging problem in bone tissue engineering. To address the most important problem in bone defect repair, namely insufficient blood supply, this study a...

    Authors: Yuanjia He, Shuang Lin, Qiang Ao and Xiaoning He

    Citation: Stem Cell Research & Therapy 2020 11:338

    Content type: Research

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  11. Selected placental mesenchymal stromal cells isolated from the fetal mesenchymal placental tissues (f-hPSCs) were tested as cell therapy of lethal acute radiation syndrome (ARS) with bone marrow regeneration a...

    Authors: Evgenia Volinsky, Astar Lazmi-Hailu, Nerel Cohen, Boaz Adani, Mohammad Faroja, Myriam Grunewald and Raphael Gorodetsky

    Citation: Stem Cell Research & Therapy 2020 11:337

    Content type: Research

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  12. Diabetic nephropathy (DN) is one of the most serious complications of diabetes and the leading cause of end-stage chronic kidney disease. Currently, there are no effective drugs for treating DN. Therefore, nov...

    Authors: E Xiang, Bing Han, Quan Zhang, Wei Rao, Zhangfan Wang, Cheng Chang, Yaqi Zhang, Chengshu Tu, Changyong Li and Dongcheng Wu

    Citation: Stem Cell Research & Therapy 2020 11:336

    Content type: Research

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  13. Mesenchymal stem cells, including those derived from human adipose tissue (hASCs), are currently being widely investigated for cell therapy. However, when transplanted at the site of injury, the survival and e...

    Authors: Patricia Garrido-Pascual, Ana Alonso-Varona, Begoña Castro, María Burón and Teodoro Palomares

    Citation: Stem Cell Research & Therapy 2020 11:335

    Content type: Research

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  14. Stem cells, including induced pluripotent stem cells (iPSCs), have tremendous potential in health care, though with several significant limitations. Each of the limitations, including immunogenicity, may block...

    Authors: Xiaokai Wang, Meng Lu, Xiaoyu Tian, Yansong Ren, Yijun Li, Meng Xiang and Sifeng Chen

    Citation: Stem Cell Research & Therapy 2020 11:334

    Content type: Research

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  15. Pulpitis is a common dental disease characterized by sustained inflammation and impaired pulp self-repair. Mesenchymal stem cell-based minimally invasive vital pulp therapy (MSC-miVPT) is a potential treatment...

    Authors: Hong Hong, Xiaochuan Chen, Kun Li, Nan Wang, Mengjie Li, Bo Yang, Xiaoqi Yu and Xi Wei

    Citation: Stem Cell Research & Therapy 2020 11:333

    Content type: Research

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  16. Cell therapy using hepatocytes derived from stem cells has been regarded as a promising alternate to liver transplantation. However, the heterogeneity of these hepatocytes makes them unsuitable for therapeutic...

    Authors: Ja Sung Choi, In Sil Jeong, Young-Jin Park and Sung-Whan Kim

    Citation: Stem Cell Research & Therapy 2020 11:332

    Content type: Research

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  17. Mesenchymal stem cells (MSCs) have a limited self-renewal ability, impaired multi-differentiation potential, and undetermined cell senescence during in vitro series expansion. To address this concern, we inves...

    Authors: Zeyuan Cao, Yunyi Xie, Le Yu, Yi Li and Yan Wang

    Citation: Stem Cell Research & Therapy 2020 11:329

    Content type: Research

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  18. Cell-based tissue engineering represents a promising management for meniscus repair and regeneration. The present study aimed to investigate whether the injection of parathyroid hormone (PTH) (1-34) could prom...

    Authors: Wen Zhao, Tong Zou, Hao Cui, Yangou Lv, Dengke Gao, Chenmei Ruan, Xia Zhang and Yihua Zhang

    Citation: Stem Cell Research & Therapy 2020 11:328

    Content type: Research

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  19. Despite the potential, bone marrow-derived mesenchymal stem cells (BMSCs) show limitations for beta (ß)-cell replacement therapy due to inefficient methods to deliver BMSCs into pancreatic lineage. In this stu...

    Authors: Nidheesh Dadheech, Abhay Srivastava, Mitul Vakani, Paresh Shrimali, Ramesh Bhonde and Sarita Gupta

    Citation: Stem Cell Research & Therapy 2020 11:327

    Content type: Research

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  20. Periodontal ligament stem cells (PDLSCs) have many applications in the field of cytotherapy, tissue engineering, and regenerative medicine. However, the effect of age on the biological and immunological charac...

    Authors: Xiaoyu Li, Bowen Zhang, Hong Wang, Xiaolu Zhao, Zijie Zhang, Gang Ding and Fulan Wei

    Citation: Stem Cell Research & Therapy 2020 11:326

    Content type: Research

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  21. Mesenchymal stem cells (MSCs) can regulate innate and adaptive immune systems through interacting with immune cells directly and secreting multiple soluble factors. Due to their immunosuppressive properties, M...

    Authors: Jingjing Qi, Xiaojun Tang, Wenchao Li, Weiwei Chen, Genhong Yao and Lingyun Sun

    Citation: Stem Cell Research & Therapy 2020 11:325

    Content type: Research

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  22. Treating patients with end-stage diffuse coronary artery disease (EnD-CAD) unsuitable for coronary intervention remains a clinical challenge. They usually express refractory angina and have a high risk of mort...

    Authors: Pei-Hsun Sung, Hsin-Ju Chiang, Yi-Chen Li, John Y. Chiang, Chi-Hsiang Chu, Pei-Lin Shao, Fan-Yen Lee, Mel S. Lee and Hon-Kan Yip

    Citation: Stem Cell Research & Therapy 2020 11:324

    Content type: Research

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  23. Extracellular vesicles (EVs) from human mesenchymal stem cells (hMSCs) are known to be mediators of intercellular communication and have been suggested as possible therapeutic agents in many diseases. Their po...

    Authors: Daphne Hingert, Karin Ekström, Jonathan Aldridge, Rosella Crescitelli and Helena Brisby

    Citation: Stem Cell Research & Therapy 2020 11:323

    Content type: Research

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  24. Burns remain a serious public health problem with high morbidity and mortality rates worldwide. Although there are various treatment options available, there is no consensus on the best treatment for severe bu...

    Authors: Yuan Li, Wei-dong Xia, Leanne Van der Merwe, Wen-tong Dai and Cai Lin

    Citation: Stem Cell Research & Therapy 2020 11:322

    Content type: Review

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  25. Bone marrow stromal cells (BMSC) have promise in cartilage tissue engineering, but for their potential to be fully realised, the propensity to undergo hypertrophy must be mitigated. The literature contains div...

    Authors: Ena Music, Kathryn Futrega, James S. Palmer, Mackenzie Kinney, Bill Lott, Travis J. Klein and Michael R. Doran

    Citation: Stem Cell Research & Therapy 2020 11:321

    Content type: Research

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  26. There are multiple promising treatment strategies for central nervous system trauma and disease. However, to develop clinically potent and safe treatments, models of human-specific conditions are needed to com...

    Authors: Chenhong Lin, Cinzia Calzarossa, Teresa Fernandez-Zafra, Jia Liu, Xiaofei Li, Åsa Ekblad-Nordberg, Erika Vazquez-Juarez, Simone Codeluppi, Lena Holmberg, Maria Lindskog, Per Uhlén and Elisabet Åkesson

    Citation: Stem Cell Research & Therapy 2020 11:320

    Content type: Research

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  27. Gestational diabetes (GDM) is a common complication of pregnancy. The impact of pregnancy complications on placental function suggests that extraembryonic stem cells in the placenta may also be affected during...

    Authors: Liyun Chen, Chung-Teng Wang, Nicholas R. Forsyth and Pensee Wu

    Citation: Stem Cell Research & Therapy 2020 11:319

    Content type: Research

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  28. MicroRNAs (miRNAs) play a role in regulating osteogenic differentiation (OD) of mesenchymal stem cells by inhibiting mRNAs translation under cyclic strain. miR-503-3p was downregulated in OD of human adipose-d...

    Authors: Yadong Luo, Xu Ding, Huan Ji, Meng Li, Haiyang Song, Sheng Li, Chenxing Wang, Heming Wu and Hongming Du

    Citation: Stem Cell Research & Therapy 2020 11:318

    Content type: Research

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  29. Upon migrating to the injured sites, bone marrow mesenchymal stem cells (BMSCs) play critical roles in the repair of bone lesion caused by chronic apical periodontitis. Emerging evidences have shown that Enteroco...

    Authors: Mingwei Li, Lifan Wei, Wei Zhou, Zhiyan He, Shujun Ran and Jingping Liang

    Citation: Stem Cell Research & Therapy 2020 11:317

    Content type: Research

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  30. MSCs isolated from bone marrow (BM-MSCs) have well-established chondrogenic potential, but MSCs derived from the synovial membrane (SM-MSCs) and synovial fluid (SF-MSCs) are thought to possess superior chondro...

    Authors: Paul Neybecker, Christel Henrionnet, Elise Pape, Laurent Grossin, Didier Mainard, Laurent Galois, Damien Loeuille, Pierre Gillet and Astrid Pinzano

    Citation: Stem Cell Research & Therapy 2020 11:316

    Content type: Research

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  31. Embryonic stem cells (ESCs) are important source of clinical stem cells for therapy, so dissecting the functional gene regulatory network involved in their self-renewal and proliferation is an urgent task. We ...

    Authors: Jingwen Wang, Jiahui Liu, Miaoman Ye, Feng Liu, Su Wu, Junjiu Huang and Guang Shi

    Citation: Stem Cell Research & Therapy 2020 11:314

    Content type: Research

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  32. Small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSC) derived from human induced pluripotent stem cells (iPSC, iMSC-sEV) are considered to have great potential in treating ischemic diseas...

    Authors: Yuguo Xia, Xiaozheng Ling, Guowen Hu, Qingwei Zhu, Juntao Zhang, Qing Li, Bizeng Zhao, Yang Wang and Zhifeng Deng

    Citation: Stem Cell Research & Therapy 2020 11:313

    Content type: Research

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  33. Adipose-derived stem cells (ADSCs) have become one of the most utilized adult stem cells due to their abundance and accessibility. Recent studies have shown that paracrine cytokines, exosomes, and other active...

    Authors: Yuan Cai, Jianyi Li, Changsha Jia, Yunfan He and Chengliang Deng

    Citation: Stem Cell Research & Therapy 2020 11:312

    Content type: Review

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  34. T helper 17 cells (Th17)/regulatory T cells (Treg), as subtypes of CD4+ T cells, play an important role in the inflammatory response of acute respiratory distress syndrome (ARDS). However, there is still a lack o...

    Authors: Jianxiao Chen, Xiwen Zhang, Jianfeng Xie, Ming Xue, Ling Liu, Yi Yang and Haibo Qiu

    Citation: Stem Cell Research & Therapy 2020 11:311

    Content type: Research

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  35. Adipose-derived mesenchymal stem cells (AD-MSCs) are a type of stem cell that is abundant and widely used. The molecular characteristics of AD-MSCs from different passages from donors of different ages have no...

    Authors: Guan-Ming Lu, Yong-Xian Rong, Zhi-Jie Liang, Dong-Lin Hunag, Yan-Fei Ma, Zhi-Zhai Luo, Fang-Xiao Wu, Xin-Heng Liu, Yu Liu, Steven Mo, Zhong-Quan Qi and Hong-Mian Li

    Citation: Stem Cell Research & Therapy 2020 11:310

    Content type: Research

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  36. Organoids play an important role in basic research, drug screening, and regenerative medicine. Here, we aimed to develop a novel kind of three-dimensional (3D) organoids generated from urine-derived stem cells...

    Authors: Guoliang Sun, Beichen Ding, Meimei Wan, Liang Chen, John Jackson and Anthony Atala

    Citation: Stem Cell Research & Therapy 2020 11:309

    Content type: Research

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  37. Multiple strategies have been proposed to promote the differentiation potential of mesenchymal stem cells (MSCs), which is the fundamental property in tissue formation and regeneration. However, these strategi...

    Authors: Kejia Li, Tong Ning, Hao Wang, Yangzi Jiang, Jue Zhang and Zigang Ge

    Citation: Stem Cell Research & Therapy 2020 11:308

    Content type: Research

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  38. Stem cells have a vast range of functions from tissue regeneration to immunoregulation. They have the ability to modulate immune responses and change the progression of different inflammatory and autoimmune di...

    Authors: Sara Shamdani, Georges Uzan and Sina Naserian

    Citation: Stem Cell Research & Therapy 2020 11:307

    Content type: Viewpoint

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  39. 7-Methylguanosine (m7G) is one of the most conserved modifications in nucleosides within tRNAs and rRNAs. It plays essential roles in the regulation of mRNA export, splicing, and translation. Recent studies highl...

    Authors: Yujie Deng, Zhongyang Zhou, Weidong Ji, Shuibin Lin and Min Wang

    Citation: Stem Cell Research & Therapy 2020 11:306

    Content type: Research

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  40. Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restric...

    Authors: Kun Xiao, Fei Hou, Xiuyu Huang, Binbin Li, Zhi Rong Qian and Lixin Xie

    Citation: Stem Cell Research & Therapy 2020 11:305

    Content type: Review

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  41. Canine inflammatory brain disease (IBD) is a severe inflammatory disorder characterized by infiltration of activated immune cell subsets into the brain and spinal cord. Multipotent mesenchymal stromal cells (M...

    Authors: Rogério Martins Amorim, Kaitlin C. Clark, Naomi J. Walker, Priyadarsini Kumar, Kyle Herout, Dori L. Borjesson and Aijun Wang

    Citation: Stem Cell Research & Therapy 2020 11:304

    Content type: Research

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  42. The epidermis, which is the outermost layer of mammalian skin, provides an essential barrier that is essential for maintenance of life. The epidermis is a stratified epithelium, which is maintained by the prol...

    Authors: Ronghua Yang, Shuai Yang, Jingling Zhao, Ximin Hu, Xiaodong Chen, Jingru Wang, Julin Xie and Kun Xiong

    Citation: Stem Cell Research & Therapy 2020 11:303

    Content type: Review

    Published on:

  43. Intracavernous injection of mesenchymal stem cells (MSCs) is a promising method for diabetic mellitus-induced erectile dysfunction (DMED), but short survival time of MSCs in cavernous is a fatal defect for the...

    Authors: Haoran Wang, Keqin Zhang, Zheng Ruan, Dingqi Sun, Hui Zhang, Guiting Lin, Liangliang Hu, Shengtian Zhao and Qiang Fu

    Citation: Stem Cell Research & Therapy 2020 11:302

    Content type: Research

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  44. Destruction or dysfunction of limbal epithelial stem cells (LESCs) leads to unilateral or bilateral limbal stem cell deficiency (LSCD). Fifteen years have passed since the first transplantation of ex vivo cult...

    Authors: Joao Victor Cabral, Catherine Joan Jackson, Tor Paaske Utheim and Katerina Jirsova

    Citation: Stem Cell Research & Therapy 2020 11:301

    Content type: Review

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  45. Despite recent advances in neonatal care, sepsis remains a leading cause of mortality in neonates. Mesenchymal stem cells derived from various tissues, such as bone marrow, umbilical cord, and adipose tissue, ...

    Authors: Yu Sato, Daigo Ochiai, Yushi Abe, Hirotaka Masuda, Marie Fukutake, Satoru Ikenoue, Yoshifumi Kasuga, Masayuki Shimoda, Yae Kanai and Mamoru Tanaka

    Citation: Stem Cell Research & Therapy 2020 11:300

    Content type: Research

    Published on:

  46. Cellular replacement strategies using human induced pluripotent stem cells (iPSCs) and their cardiac derivatives are emerging as novel treatments for post-myocardial infarction (MI) heart failure (HF); however...

    Authors: Xin Jiang, Ziyi Yang and Ming Dong

    Citation: Stem Cell Research & Therapy 2020 11:297

    Content type: Research

    Published on:

  47. This study was designed to determine the effect of human umbilical cord multipotent mesenchymal stromal cells (hUC-MSC) on acute ischemia/reperfusion (I/R) injury of spermatogenic cells.

    Authors: Liang Zhong, Mengbo Yang, Xiangyu Zou, Tao Du, Huiming Xu and Jie Sun

    Citation: Stem Cell Research & Therapy 2020 11:294

    Content type: Research

    Published on:

  48. There have been limited advances in the treatment of bone and joint infections, which currently involves a combination of surgery and antibiotic administration. There is a timely need in orthopedics to develop...

    Authors: Haruyo Yagi, Antonia F. Chen, David Hirsch, Adam C. Rothenberg, Jian Tan, Peter G. Alexander and Rocky S. Tuan

    Citation: Stem Cell Research & Therapy 2020 11:293

    Content type: Research

    Published on:

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