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  1. Currently, mesenchymal stem/stromal stem cell (MSC) therapy has become a promising option for accelerating cutaneous wound healing. In vivo reports have outlined the robust competences of MSCs to offer a solid...

    Authors: Faroogh Marofi, Kozlitina Iuliia Alexandrovna, Ria Margiana, Mahta Bahramali, Wanich Suksatan, Walid Kamal Abdelbasset, Supat Chupradit, Maryam Nasimi and Marwah Suliman Maashi

    Citation: Stem Cell Research & Therapy 2021 12:597

    Content type: Review

    Published on:

  2. With the development of tissue engineering, enhanced tendon regeneration could be achieved by exploiting suitable cell types and biomaterials. The accessibility, robust cell amplification ability, superior ten...

    Authors: Jialin Chen, Qingyun Mo, Renwang Sheng, Aijing Zhu, Chen Ling, Yifan Luo, Aini Zhang, Zhixuan Chen, Qingqiang Yao, Zhuoying Cai and Wei Zhang

    Citation: Stem Cell Research & Therapy 2021 12:596

    Content type: Research

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  3. SATB2-associated syndrome (SAS) is a multisystem disorder caused by mutation of human SATB2 gene. Tooth agenesis is one of the most common phenotypes observed in SAS. Our study aimed at identifying novel variant ...

    Authors: Tianyi Xin, Qian Li, Rushui Bai, Ting Zhang, Yanheng Zhou, Yuehua Zhang, Bing Han and Ruili Yang

    Citation: Stem Cell Research & Therapy 2021 12:595

    Content type: Research

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  4. Optic neuritis (ON) is frequently encountered in multiple sclerosis, neuromyelitis optica spectrum disorder, anti-myelin oligodendrocyte glycoprotein associated disease, and other systemic autoimmune disorders...

    Authors: Anagha Aneesh, Alice Liu, Heather E. Moss, Douglas Feinstein, Sriram Ravindran, Biji Mathew and Steven Roth

    Citation: Stem Cell Research & Therapy 2021 12:594

    Content type: Review

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  5. Electronic-cigarette (e-cig) usage, particularly in the youth population, is a growing concern. It is known that e-cig causes endothelial dysfunction, which is a risk factor for the development of cardiovascul...

    Authors: Hoai Huong Thi Le, Chen-wei Liu, Philip Denaro III, Jordan Jousma, Ning-Yi Shao, Irfan Rahman and Won Hee Lee

    Citation: Stem Cell Research & Therapy 2021 12:593

    Content type: Research

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  6. The invasive and complicated procedures involving the use of traditional stem cells limit their application in bone tissue engineering. Cell-free, tissue-engineered bones often have complex scaffold structures...

    Authors: Jiachen Sun, Lang Li, Fei Xing, Yun Yang, Min Gong, Guoming Liu, Shuang Wu, Rong Luo, Xin Duan, Ming Liu, Min Zou and Zhou Xiang

    Citation: Stem Cell Research & Therapy 2021 12:591

    Content type: Research

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  7. Self-limited Childhood Epilepsies are the most prevalent epileptic syndrome in children. Its pathogenesis is unknown. In this disease, symptoms resolve spontaneously in approximately 50% of patients when matur...

    Authors: Mariana L. Casalia, Juan Cruz Casabona, Corina García, Verónica Cavaliere Candedo, Héctor Ramiro Quintá, María Isabel Farías, Joaquín Gonzalez, Dolores Gonzalez Morón, Marta Córdoba, Damian Consalvo, Gustavo Mostoslavsky, Francisco J. Urbano, Juana Pasquini, Mario Gustavo Murer, Lorena Rela, Marcelo A. Kauffman…

    Citation: Stem Cell Research & Therapy 2021 12:590

    Content type: Research

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  8. PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is in...

    Authors: So-Young Lee, Hyun-Ju An, Jin Man Kim, Min-Ji Sung, Do Kyung Kim, Hyung Kyung Kim, Jongbeom Oh, Hye Yun Jeong, Yu Ho Lee, Taeyoung Yang, Jun Han Kim, Ha Jeong Lim and Soonchul Lee

    Citation: Stem Cell Research & Therapy 2021 12:589

    Content type: Research

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  9. Liver transplantation (LT) is required in many end-stage liver diseases. Donation after cardiac death (DCD) livers are often used, and treatment of acute rejection (ACR) requires the use of immunosuppressive d...

    Authors: Huan Cao, Longlong Wu, Xuan Tian, Weiping Zheng, Mengshu Yuan, Xiang Li, Xiaorong Tian, Yuxin Wang, Hongli Song and Zhongyang Shen

    Citation: Stem Cell Research & Therapy 2021 12:587

    Content type: Research

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  10. Injection of autologous adipose tissue (AT) has recently been demonstrated to be an effective and safe treatment for anal fistulas. AT mesenchymal stem cells (AT-MSCs) mediate the healing process, but the rela...

    Authors: Michaela Tencerova, Lilli Lundby, Steen Buntzen, Stig Norderval, Helene Tarri Hougaard, Bodil Ginnerup Pedersen and Moustapha Kassem

    Citation: Stem Cell Research & Therapy 2021 12:586

    Content type: Research

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  11. Human embryonic stem cells (hESCs) transplantation had shown to provide a potential source of cells in neurodegenerative disease studies and lead to behavioral recovery in lentivirus transfected or, toxin-indu...

    Authors: Jaisan Islam, Kyoung Ha So, Elina KC, Hyeong Cheol Moon, Aryun Kim, Sang Hwan Hyun, Soochong Kim and Young Seok Park

    Citation: Stem Cell Research & Therapy 2021 12:585

    Content type: Research

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  12. Ischemic heart diseases is one of the leading causes of death worldwide. Although revascularization timely is an effective therapeutic intervention to salvage the ischemic myocardium, reperfusion itself causes...

    Authors: Jinting Yang, Lihui Tang, Fengjiang Zhang, Tingting Yang, Ting Lu, Kai Sun, Na Sun, Jinxuan Ren and Min Yan

    Citation: Stem Cell Research & Therapy 2021 12:584

    Content type: Research

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  13. Biliary atresia (BA) is a severe hepatobiliary disease in infants that ultimately results in hepatic failure; however, its pathological mechanism is poorly elucidated. Current surgical options, including Kasai...

    Authors: Soichiro Sonoda, Koichiro Yoshimaru, Haruyoshi Yamaza, Ratih Yuniartha, Toshiharu Matsuura, Erika Yamauchi-Tomoda, Sara Murata, Kento Nishida, Yoshinao Oda, Shouichi Ohga, Tasturo Tajiri, Tomoaki Taguchi and Takayoshi Yamaza

    Citation: Stem Cell Research & Therapy 2021 12:582

    Content type: Research

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  14. Recently, great efforts have been made to design protocols for obtaining ocular cells from human stem cells to model diseases or for regenerative purposes. Current protocols generally focus on isolating retina...

    Authors: Helena Isla-Magrané, Anna Veiga, José García-Arumí and Anna Duarri

    Citation: Stem Cell Research & Therapy 2021 12:581

    Content type: Research

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  15. Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR g...

    Authors: Shin Yi Tang, Shijun Zha, Zhicheng Du, Jieming Zeng, Detu Zhu, Yumei Luo and Shu Wang

    Citation: Stem Cell Research & Therapy 2021 12:580

    Content type: Research

    Published on:

  16. The fate of hematopoietic stem cells (HSCs) is determined by a complex regulatory network that includes both intrinsic and extrinsic signals. In the past decades, many intrinsic key molecules of HSCs have been...

    Authors: Jing Zhang, Yaozhen Chen, Dandan Yin, Fan Feng, Qunxing An, Zhixin Liu, Ning An, Jinmei Xu, Jing Yi, Shunli Gu, Wen Yin, Yazhou Wang and Xingbin Hu

    Citation: Stem Cell Research & Therapy 2021 12:579

    Content type: Research

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  17. Lymphedema, the accumulation of interstitial fluid caused by poor lymphatic drainage, is a progressive and permanent disease with no curative treatment. Several studies have evaluated cell-based therapies in s...

    Authors: Hector Lafuente, Ibon Jaunarena, Eukene Ansuategui, Arantza Lekuona and Ander Izeta

    Citation: Stem Cell Research & Therapy 2021 12:578

    Content type: Review

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  18. Diabetes mellitus causes deterioration in the body, including serious damage of the oral cavity related to salivary gland dysfunction, characterised by hyposalivation and xerostomia. Human dental pulp stem cel...

    Authors: Rasha H. Al-Serwi, Ahmed Othman Fathy Othman El-Kersh and Gehan El-Akabawy

    Citation: Stem Cell Research & Therapy 2021 12:577

    Content type: Research

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  19. Bone formation plays an important role in early tendon–bone healing after anterior cruciate ligament reconstruction (ACLR). Dedifferentiated osteogenic bone marrow mesenchymal stem cells (De-BMSCs) have enhanc...

    Authors: Kai Tie, Jinghang Cai, Jun Qin, Hao Xiao, Yangfan Shangguan, Hui Wang and Liaobin Chen

    Citation: Stem Cell Research & Therapy 2021 12:576

    Content type: Research

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  20. Three-dimensional (3D) spheroid culture can promote the osteogenic differentiation of bone marrow mesenchymal stromal cells (BMSC). 3D printing offers the possibility to produce customized scaffolds for comple...

    Authors: Siddharth Shanbhag, Salwa Suliman, Samih Mohamed-Ahmed, Carina Kampleitner, Mohamed Nageeb Hassan, Patrick Heimel, Toni Dobsak, Stefan Tangl, Anne Isine Bolstad and Kamal Mustafa

    Citation: Stem Cell Research & Therapy 2021 12:575

    Content type: Research

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  21. Stem cell-based therapies for neurodegenerative diseases like Parkinson’s disease are a promising approach in regenerative medicine and are now moving towards early stage clinical trials. However, a number of ...

    Authors: Miranda Robbins, Venkat Pisupati, Roberta Azzarelli, Samer I. Nehme, Roger A. Barker, Ljiljana Fruk and Gabriele S. Kaminski Schierle

    Citation: Stem Cell Research & Therapy 2021 12:574

    Content type: Research

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  22. Osteoporosis is a common bone disease in elderly population caused by imbalanced bone formation and bone resorption. Mesenchymal stem cells (MSCs) are responsible for maintaining this bone homeostasis. The phe...

    Authors: Libo Yu, Mingxu Xie, Fengjie Zhang, Chao Wan and Xiaoqiang Yao

    Citation: Stem Cell Research & Therapy 2021 12:573

    Content type: Research

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  23. Cartilage damage is a common medical issue in clinical practice. Complete cartilage repair remains a significant challenge owing to the inferior quality of regenerative tissue. Safe and non-invasive magnetic t...

    Authors: Jiyuan Yan, Chaoxu Liu, Chang Tu, Ruizhuo Zhang, Xiangyu Tang, Hao Li, Huaixi Wang, Yongzhuang Ma, Yingchi Zhang, Hua Wu and Gaohong Sheng

    Citation: Stem Cell Research & Therapy 2021 12:572

    Content type: Research

    Published on:

  24. Umbilical cord-derived mesenchymal stromal cells (UC-MSCs) revealed their key role in immune regulation, offering promising therapeutic perspectives for immune and inflammatory diseases. We aimed to develop a ...

    Authors: Miryam Mebarki, Nathan Iglicki, Céline Marigny, Camille Abadie, Claire Nicolet, Guillaume Churlaud, Camille Maheux, Hélène Boucher, Antoine Monsel, Philippe Menasché, Jérôme Larghero, Lionel Faivre and Audrey Cras

    Citation: Stem Cell Research & Therapy 2021 12:571

    Content type: Research

    Published on:

  25. Amnion-derived mesenchymal stem cells (AM-MSCs) are an attractive source of stem cell therapy for patients with irreversible liver disease. However, there are obstacles to their use due to low efficiency and x...

    Authors: Jiwan Choi, Seoon Kang, Bitnara Kim, Seongjun So, Jongsuk Han, Gyeong-Nam Kim, Mi-Young Lee, Seonae Roh, Ji-Yoon Lee, Soo Jin Oh, Young Hoon Sung, Yeonmi Lee, Sung Hoon Kim and Eunju Kang

    Citation: Stem Cell Research & Therapy 2021 12:569

    Content type: Research

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  26. Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These...

    Authors: Yajing Wang, Dan Ma, Zewen Wu, Baoqi Yang, Rong Li, Xingxing Zhao, Helin Yang and Liyun Zhang

    Citation: Stem Cell Research & Therapy 2021 12:567

    Content type: Review

    Published on:

  27. Diabetic patients are more vulnerable to skeletal complications. Peroxisome proliferators-activated receptor (PPAR) β/δ has a positive regulatory effect on bone turnover under physiologic glucose concentration...

    Authors: Miao Chen, Dian Jing, Rui Ye, Jianru Yi and Zhihe Zhao

    Citation: Stem Cell Research & Therapy 2021 12:566

    Content type: Research

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  28. Human Mesenchymal stromal cells (hMSCs) from various tissue sources are widely investigated in clinical trials. These MSCs are often administered to patients immediately after thawing the cryopreserved product...

    Authors: Camila Medrano-Trochez, Paramita Chatterjee, Pallab Pradhan, Hazel Y. Stevens, Molly E. Ogle, Edward A. Botchwey, Joanne Kurtzberg, Carolyn Yeago, Greg Gibson and Krishnendu Roy

    Citation: Stem Cell Research & Therapy 2021 12:565

    Content type: Research

    Published on:

  29. Vibrio cholerae is the causative agent of cholera, which is commonly associated with high morbidity and mortality, and presents a major challenge to healthcare systems throughout the world. Lipopolysaccharide (LP...

    Authors: Mahboube Bahroudi, Bita Bakhshi, Sara Soudi and Shahin Najar-peerayeh

    Citation: Stem Cell Research & Therapy 2021 12:564

    Content type: Research

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  30. Although numerous studies demonstrate the role of cancer stem cells in occurrence, recurrence, and distant metastases in gastric cancer (GC), little is known about the evolving genetic and epigenetic changes i...

    Authors: Renshen Xiang, Wei Song, Jun Ren, Jing Wu, Jincheng Fu and Tao Fu

    Citation: Stem Cell Research & Therapy 2021 12:563

    Content type: Research

    Published on:

  31. To evaluate the safety and efficacy of intra-articular (IA) injection of allogeneic adipose-derived stem cells (ADSCs) ELIXCYTE® for knee osteoarthritis.

    Authors: Cheng-Fong Chen, Chih-Chien Hu, Chen-Te Wu, Hung-Ta H. Wu, Chun-Shin Chang, Yi-Pei Hung, Chia-Chu Tsai and Yuhan Chang

    Citation: Stem Cell Research & Therapy 2021 12:562

    Content type: Research

    Published on:

  32. Exosomes are extracellular vesicles secreted by various cells, mainly composed of lipid bilayers without organelles. In recent years, an increasing number of researchers have focused on the use of exosomes for...

    Authors: Yao Sun, Guoliang Liu, Kai Zhang, Qian Cao, Tongjun Liu and Jiannan Li

    Citation: Stem Cell Research & Therapy 2021 12:561

    Content type: Review

    Published on:

  33. The adult mammalian retina does not have the capacity to regenerate cells lost due to damage or disease. Therefore, retinal injuries and blinding diseases result in irreversible vision loss. However, retinal s...

    Authors: Kenneth N. Grisé, Brenda L. K. Coles, Nelson X. Bautista and Derek van der Kooy

    Citation: Stem Cell Research & Therapy 2021 12:560

    Content type: Research

    Published on:

  34. Diabetic cutaneous ulcers (DCU) are a complication of diabetes with diabetic foot ulcers being the most common, and the wounds are difficult to heal, increasing the risk of bacterial infection. Cell-based ther...

    Authors: Yiren Jiao, Xiaolin Chen, Yongxia Niu, Sunxing Huang, Jingwen Wang, Mingxun Luo, Guang Shi and Junjiu Huang

    Citation: Stem Cell Research & Therapy 2021 12:559

    Content type: Research

    Published on:

  35. End-stage liver disease (ESLD) is characterized by the deterioration of liver function and a subsequent high mortality rate. Studies have investigated the use of adult stem cells to treat ESLD. Here, a systema...

    Authors: Chen-Hui Zhu, Dian-Han Zhang, Chen-Wei Zhu, Jing Xu, Chuan-Long Guo, Xiang-Gen Wu, Qi-Long Cao and Guo-Hu Di

    Citation: Stem Cell Research & Therapy 2021 12:558

    Content type: Review

    Published on:

  36. Vitamin D is important for the mineralization of bones by stimulating osteoblast differentiation of bone marrow mesenchymal stem cells (BMMSCs). BMMSCs are a target of vitamin D action, and the metabolism of 2...

    Authors: Qiting He, Ruixi Qin, Julie Glowacki, Shuanhu Zhou, Jie Shi, Shaoyi Wang, Yuan Gao and Lei Cheng

    Citation: Stem Cell Research & Therapy 2021 12:557

    Content type: Research

    Published on:

  37. Intrauterine adhesion refers to endometrial repair disorders which are usually caused by uterine injury and may lead to a series of complications such as abnormal menstrual bleeding, recurrent abortion and sec...

    Authors: Yu-Ting Song, Peng-Cheng Liu, Jie Tan, Chen-Yu Zou, Qian-Jin Li, Jesse Li-Ling and Hui-Qi Xie

    Citation: Stem Cell Research & Therapy 2021 12:556

    Content type: Review

    Published on:

  38. Cell therapy provides hope for treatment of advanced liver failure. Proliferating human hepatocytes (ProliHHs) were derived from primary human hepatocytes (PHH) and as potential alternative for cell therapy in...

    Authors: Chen Ma, Ludi Zhang, Ting He, Huiying Cao, Xiongzhao Ren, Chenhui Ma, Jiale Yang, Ruimin Huang and Guoyu Pan

    Citation: Stem Cell Research & Therapy 2021 12:555

    Content type: Research

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  39. The corneal endothelium plays a key role in maintaining corneal transparency. Its dysfunction is currently treated with penetrating or lamellar keratoplasty. Advanced cell therapy methods seek to address the p...

    Authors: Ingrida Smeringaiova, Tor Paaske Utheim and Katerina Jirsova

    Citation: Stem Cell Research & Therapy 2021 12:554

    Content type: Review

    Published on:

  40. Studying human germ cell development and male infertility is heavily relied on mouse models. In vitro differentiation of human pluripotent stem cells into spermatogonial stem cell-like cells (SSCLCs) can be us...

    Authors: Xiaotong Wang, Mengyuan Qu, Zili Li, Yuting Long, Kai Hong and Honggang Li

    Citation: Stem Cell Research & Therapy 2021 12:553

    Content type: Research

    Published on:

  41. Cell-based therapeutic strategies have been proposed as an alternative for brain repair after stroke, but their clinical application has been hampered by potential adverse effects in the long term. The present...

    Authors: Rodrigo Azevedo Loiola, Miguel García-Gabilondo, Alba Grayston, Paulina Bugno, Agnieszka Kowalska, Sophie Duban-Deweer, Eleonora Rizzi, Johan Hachani, Yasuteru Sano, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, Maciej Piotr Mazurek, Anna Rosell and Fabien Gosselet

    Citation: Stem Cell Research & Therapy 2021 12:552

    Content type: Research

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  42. Cholesterol accumulation and calcium depletion induce hepatic injury via the endoplasmic reticulum (ER) stress response. ER stress regulates the calcium imbalance between the ER and mitochondria. We previously...

    Authors: Se Ho Kim, Jae Yeon Kim, Soo Young Park, Won Tae Jeong, Jin Man Kim, Si Hyun Bae and Gi Jin Kim

    Citation: Stem Cell Research & Therapy 2021 12:551

    Content type: Research

    Published on:

  43. Stearoyl-coenzyme A desaturase 1 (SCD1) is required for de novo synthesis of fatty acids. Through the fatty acid acylation process, this enzyme orchestrates post-translational modifications to proteins involve...

    Authors: Vahid Hosseini, Ashkan Kalantary-Charvadeh, Maryam Hajikarami, Parisa Fayyazpour, Reza Rahbarghazi, Mehdi Totonchi and Masoud Darabi

    Citation: Stem Cell Research & Therapy 2021 12:550

    Content type: Research

    Published on:

  44. Alopecia areata (AA) is a common autoimmune hair loss disease with increasing incidence. Corticosteroids are the most widely used for hair loss treatment; however, long-term usage of hormonal drugs is associat...

    Authors: Weiyue Deng, Yuying Zhang, Wei Wang, Aishi Song, Omar Mukama, Jiarong Huang, Xiaobo Han, Sihao Deng, Zuoxian Lin, Jean du Dieu Habimana, Rongqi Huang, Kexin Peng, Bing Ni, Shusheng Zhang, Xiaoxin Yan, Ji Li…

    Citation: Stem Cell Research & Therapy 2021 12:548

    Content type: Research

    Published on:

  45. Hepatic schistosomiasis, a chronic liver injury induced by long-term Schistosoma japonicum (S. japonicum) infection, is characterized by egg granulomas and fibrotic pathology. Hepatic progenitor cells (HPCs), whi...

    Authors: Beibei Zhang, Xiaoying Wu, Jing Li, An Ning, Bo Zhang, Jiahua Liu, Langui Song, Chao Yan, Xi Sun, Kuiyang Zheng and Zhongdao Wu

    Citation: Stem Cell Research & Therapy 2021 12:546

    Content type: Research

    Published on:

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