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  1. Content type: Research

    Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular diseases (CVD) and vascular health. Peripheral blood-derived CD34+ progenitor cells have been used as biomarker for CVD risk and m...

    Authors: Cleyton C. Domingues, Fiona J. Dore, Alexander Cho, Neeki Ahmadi, Yana Kropotova, Nabanita Kundu, Naji Younes, Vivek Jain and Sabyasachi Sen

    Citation: Stem Cell Research & Therapy 2019 10:147

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  2. Content type: Research

    Survival and therapeutic actions of bone marrow-derived mesenchymal stem cells (BMMSCs) can be limited by the hostile microenvironment present during acute spinal cord injury (SCI). Here, we investigated wheth...

    Authors: Kyan James Allahdadi, Thaís Alves de Santana, Girlaine Café Santos, Carine Machado Azevedo, Roberta Alves Mota, Carolina Kymie Nonaka, Daniela Nascimento Silva, Clarissa Xavier Resende Valim, Cláudio Pereira Figueira, Washington Luis Conrado dos Santos, Renan Fernandes do Espirito Santo, Afrânio Ferreira Evangelista, Cristiane Flora Villarreal, Ricardo Ribeiro dos Santos, Bruno Solano Freitas de Souza and Milena Botelho Pereira Soares

    Citation: Stem Cell Research & Therapy 2019 10:146

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  3. Content type: Research

    Glioblastoma (GBM) is the most common type of primary malignant brain tumor. Molecular hydrogen has been considered a preventive and therapeutic medical gas in many diseases including cancer. In our study, we ...

    Authors: Meng-yu Liu, Fei Xie, Yan Zhang, Ting-ting Wang, Sheng-nan Ma, Peng-xiang Zhao, Xin Zhang, Tyler W. Lebaron, Xin-long Yan and Xue-mei Ma

    Citation: Stem Cell Research & Therapy 2019 10:145

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  4. Content type: Research

    Non-small cell lung cancer (NSCLC) is the second most prevalent cause of cancer-related fatality. Long non-coding RNAs (lncRNAs) have been observed to exercise functions in NSCLC. Here, the current study aimed...

    Authors: Peng Li, Wenqun Xing, Jinliang Xu, Dongfeng Yuan, Guanghui Liang, Baoxing Liu and Haibo Ma

    Citation: Stem Cell Research & Therapy 2019 10:144

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  5. Content type: Research

    Human adipose-derived mesenchymal progenitor cells (haMPCs) are stem cells with multiple differentiation potential and immunomodulatory function. Re-Join® comprises in vitro expanded haMPCs from adipose tissue...

    Authors: Liangjing Lu, Chengxiang Dai, Zhongwen Zhang, Hui Du, Suke Li, Ping Ye, Qiong Fu, Li Zhang, Xiaojing Wu, Yuru Dong, Yang Song, Dongbao Zhao, Yafei Pang and Chunde Bao

    Citation: Stem Cell Research & Therapy 2019 10:143

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  6. Content type: Research

    Angiogenesis, as an endogenous repair mechanism, plays crucial roles in wound healing and tissue regeneration. However, this process is impaired in the elderly due to aging-related vascular endothelial dysfunc...

    Authors: Bi Chen, Yongjin Sun, Juntao Zhang, Qingwei Zhu, Yunlong Yang, Xin Niu, Zhifeng Deng, Qing Li and Yang Wang

    Citation: Stem Cell Research & Therapy 2019 10:142

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  7. Content type: Short report

    Visceral (VS) fat depot is known to have defective adipogenic functions compared to subcutaneous (SC) fat, but its mechanism of origin is unclear.

    Authors: Sandhya Sriram, Chengxiang Yuan, Smarajit Chakraborty, Winson Tay, Min Park, Asim Shabbir, Sue-Anne Toh, Weiping Han and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2019 10:141

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  8. Content type: Research

    Peripheral arterial disease (PAD) is a common cause of disability and mortality. The reconstruction of blood circulation presents to be the key to treatment, which can be achieved by surgery and interventional...

    Authors: Wei Gao, Dawei Chen, Guanjian Liu and Xingwu Ran

    Citation: Stem Cell Research & Therapy 2019 10:140

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  9. Content type: Research

    Nuclear factor-κB (NF-κB), an important transcription factor, participates in many physiological and pathological processes such as growth, differentiation, organogenesis, apoptosis, inflammation, and immune r...

    Authors: Yan Liang, Guoqing Chen, Yuzhi Yang, Ziyue Li, Tian Chen, Wenhua Sun, Mei Yu, Kuangwu Pan, Weihua Guo and Weidong Tian

    Citation: Stem Cell Research & Therapy 2019 10:139

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  10. Content type: Research

    Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative therapeutic approach for different hematological malignancies (HMs), and epigenetic modifications, including DNA methylation, play a rol...

    Authors: Stefania Trino, Pietro Zoppoli, Angelo Michele Carella, Ilaria Laurenzana, Alessandro Weisz, Domenico Memoli, Giovanni Calice, Francesco La Rocca, Vittorio Simeon, Lucia Savino, Luigi Del Vecchio, Pellegrino Musto, Antonella Caivano and Luciana De Luca

    Citation: Stem Cell Research & Therapy 2019 10:138

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  11. Content type: Research

    Human pluripotent stem cells (hPSCs) provide supplies of potential functional blood cells to suffice the clinical needs. However, the underlying mechanism of generating genuine hematopoietic stem cells (HSCs) ...

    Authors: Yv Wang, Jie Gao, Hongtao Wang, Mengge Wang, Yuqi Wen, Jiaojiao Guo, Pei Su, Lihong Shi, Wen Zhou and Jiaxi Zhou

    Citation: Stem Cell Research & Therapy 2019 10:136

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  12. Content type: Research

    Xenotransplantation of spermatogonial stem cells (SSCs) has become a popular topic in various research fields because manipulating these cells can provide insights into the mechanisms associated with germ cell...

    Authors: Naira Caroline Godoy Pieri, Ana Carolina Furlanetto Mançanares, Aline Fernanda de Souza, Hugo Fernandes, Angela Maria Gonella Diaza, Fabiana Fernandes Bressan, Kelly Cristine Santos Roballo, Juliana Barbosa Casals, Mario Binelli, Carlos Eduardo Ambrósio and Daniele dos Santos Martins

    Citation: Stem Cell Research & Therapy 2019 10:135

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  13. Content type: Research

    Concentrated growth factor (CGF), as a natural biomaterial, is known to contain platelets, cytokines, and growth factors to facilitate the healing process, but there has been little information acquired in reg...

    Authors: Fangfang Xu, Lu Qiao, Yumei Zhao, Weiting Chen, Shebing Hong, Jing Pan and Beizhan Jiang

    Citation: Stem Cell Research & Therapy 2019 10:134

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  14. Content type: Research

    Delivery of endothelial cells into the ischemic tissue is emerging as an alternative approach in revascularization of injured tissues by means of angiogenesis to restore organ function. Adipose-derived stem ce...

    Authors: Ting Shang, Shuaijun Li, Yun Zhang, Laiya Lu, Lei Cui and Fang Fang Guo

    Citation: Stem Cell Research & Therapy 2019 10:133

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  15. Content type: Correction

    The original article [1] contained an error in the presentation of the first author’s name, Nádia de Cássia Noronha. This has now been corrected.

    Authors: Nádia de Cássia Noronha, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim

    Citation: Stem Cell Research & Therapy 2019 10:132

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    The original article was published in Stem Cell Research & Therapy 2019 10:131

  16. Content type: Review

    Multipotent mesenchymal stromal cells (MSC) have been widely explored for cell-based therapy of immune-mediated, inflammatory, and degenerative diseases, due to their immunosuppressive, immunomodulatory, and r...

    Authors: Nádia de Cássia Noronha NC, Amanda Mizukami, Carolina Caliári-Oliveira, Juçara Gastaldi Cominal, José Lucas M. Rocha, Dimas Tadeu Covas, Kamilla Swiech and Kelen C. R. Malmegrim

    Citation: Stem Cell Research & Therapy 2019 10:131

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  17. Content type: Research

    Pluripotent stem cells are attractive progenitor cells for the generation of erythroid cells in vitro as have expansive proliferative potential. However, although embryonic (ESC) and induced pluripotent (iPSC)...

    Authors: Kongtana Trakarnsanga, Daniel Ferguson, Deborah E. Daniels, Rebecca E. Griffiths, Marieangela C. Wilson, Kathryn E. Mordue, Abi Gartner, Tatyana N. Andrienko, Annabel Calvert, Alison Condie, Angela McCahill, Joanne C. Mountford, Ashley M. Toye, David J. Anstee and Jan Frayne

    Citation: Stem Cell Research & Therapy 2019 10:130

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  18. Content type: Research

    Poor cell engraftment and survival after transplantation limited the application of stem cell therapy. Synthetic biomaterials could provide an artificial microenvironment for stem cells, thereby improve cell s...

    Authors: Nianhuan Zhao, Zhiwei Yue, Jian Cui, Yong Yao, Xianghe Song, Bangping Cui, Xin Qi, Zhibo Han, Zhong-Chao Han, Zhikun Guo, Zuo-Xiang He and Zongjin Li

    Citation: Stem Cell Research & Therapy 2019 10:129

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  19. Content type: Research

    Odontoblast is a unique progenitor that plays a role in dentin formation. So far, the dentinogenic differentiation of dental pulp stem cells and the role of surface molecules of odontoblasts in dentinogenesis ...

    Authors: Kyung-Jung Kang, Chun-Jeih Ryu and Young-Joo Jang

    Citation: Stem Cell Research & Therapy 2019 10:128

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  20. Content type: Research

    Bone-derived mesenchymal stem cell (BMSC) transplantation has been reported to be effective for the treatment of ischemic heart disease, but whether BMSCs are the optimal cell type remains under debate. Increa...

    Authors: Dihan Lu, Yan Liao, Shuang-Hua Zhu, Qiao-Chao Chen, Dong-Mei Xie, Jian-Jun Liao, Xia Feng, Mei Hua Jiang and Wen He

    Citation: Stem Cell Research & Therapy 2019 10:127

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  21. Content type: Research

    The treatment of extensive and/or chronic skin wounds is a widespread and costly public health problem. Mesenchymal stem cells (MSCs) have been proposed as a potential cell therapy for inducing wound healing i...

    Authors: José E. Millán-Rivero, Carlos M. Martínez, Paola A. Romecín, Salvador D. Aznar-Cervantes, Marina Carpes-Ruiz, José L. Cenis, Jose M. Moraleda, Noemí M. Atucha and David García-Bernal

    Citation: Stem Cell Research & Therapy 2019 10:126

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  22. Content type: Review

    Stem cell transplantation (SCT) has become a promising way to treat ischemic heart failure (IHF). We performed a large-scale meta-analysis of randomized clinical trials to investigate the efficacy and safety o...

    Authors: Yixuan Wang, Fen Xu, Jingwei Ma, Jiawei Shi, Si Chen, Zongtao Liu and Junwei Liu

    Citation: Stem Cell Research & Therapy 2019 10:125

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  23. Content type: Review

    Emerging evidence shows that epithelial-mesenchymal transition (EMT) plays a crucial role in tumor invasion, metastasis, cancer stem cells, and drug resistance. Data obtained thus far have revealed that F-box ...

    Authors: Yizuo Song, Min Lin, Yi Liu, Zhi-Wei Wang and Xueqiong Zhu

    Citation: Stem Cell Research & Therapy 2019 10:124

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  24. Content type: Research

    IL-33 is a pleiotropic cytokine of the IL-1 family, which has been reported to implicate in both innate and adaptive immune responses. Recent studies suggest IL-33 is crucial for regulation of myelopoiesis and...

    Authors: Ping Huang, Xiangyong Li, Ying Meng, Baohong Yuan, Tao Liu, Mengya Jiao, Xiaodi Wang, Yunjun Liu and Hui Yin

    Citation: Stem Cell Research & Therapy 2019 10:123

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  25. Content type: Research

    Sox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs ...

    Authors: Shuchen Zhang, Emma Bell, Huihan Zhi, Sarah Brown, Siti A. M. Imran, Véronique Azuara and Wei Cui

    Citation: Stem Cell Research & Therapy 2019 10:122

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  26. Content type: Research

    Retina and/or optic nerve injury may cause irreversible blindness, due to degeneration of retinal ganglion cells. We and others have previously shown that the intravitreal injection of mesenchymal stem cells (...

    Authors: Louise A. Mesentier-Louro, Leandro C. Teixeira-Pinheiro, Fernanda Gubert, Juliana F. Vasques, Almir J. Silva-Junior, Luiza Chimeli-Ormonde, Gabriel Nascimento-dos-Santos, Rosalia Mendez-Otero and Marcelo F. Santiago

    Citation: Stem Cell Research & Therapy 2019 10:121

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  27. Content type: Review

    In mammals, a basal level of autophagy, a self-eating cellular process, degrades cytosolic proteins and subcellular organelles in lysosomes to provide energy, recycles the cytoplasmic components, and regenerat...

    Authors: Chenxia Hu, Lingfei Zhao, Daxian Wu and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:120

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  28. Content type: Review

    Stem cell-based therapy appears to be a promising new candidate for acute kidney injury (AKI) management. Traditionally, it has been accepted that the mechanism underlying the regenerative effect of stem cells...

    Authors: Lingfei Zhao, Chenxia Hu, Ping Zhang, Hua Jiang and Jianghua Chen

    Citation: Stem Cell Research & Therapy 2019 10:119

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  29. Content type: Research

    Adult stem cells exist in a quiescent state (G0) within the in vivo niche; the loss of quiescence often leads to a decrease in the number and function of adult stem cells, impairing tissue regeneration and rep...

    Authors: Bin Li, Chao Sun, Jing Sun, Ming-hui Yang, Rui Zuo, Chang Liu, Wei-ren Lan, Ming-han Liu, Bo Huang and Yue Zhou

    Citation: Stem Cell Research & Therapy 2019 10:118

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  30. Content type: Research

    Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or mac...

    Authors: Shihua Wang, Xiaodong Su, Meiqian Xu, Xian Xiao, Xiaoxia Li, Hongling Li, Armand Keating and Robert Chunhua Zhao

    Citation: Stem Cell Research & Therapy 2019 10:117

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  31. Content type: Research

    The mechanisms underpinning the regenerative capabilities of mesenchymal stem cells (MSC) were originally thought to reside in their ability to recognise damaged tissue and to differentiate into specific cell ...

    Authors: Robert Mitchell, Ben Mellows, Jonathan Sheard, Manuela Antonioli, Oliver Kretz, David Chambers, Marie-Theres Zeuner, James E. Tomkins, Bernd Denecke, Luca Musante, Barbara Joch, Florence Debacq-Chainiaux, Harry Holthofer, Steve Ray, Tobias B. Huber, Joern Dengjel…

    Citation: Stem Cell Research & Therapy 2019 10:116

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  32. Content type: Research

    Mesenchymal stem cells (MSCs) and their cellular response to various stimuli have been characterized in great detail in culture conditions. In contrast, the cellular response of MSCs in an in vivo setting is s...

    Authors: Ramil Hakim, Ruxandra Covacu, Vasilios Zachariadis, Arvid Frostell, Sreenivasa Raghavan Sankavaram, Lou Brundin and Mikael Svensson

    Citation: Stem Cell Research & Therapy 2019 10:115

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  33. Content type: Research

    Recent studies have shown that deficiency in the Fanconi anemia (FA) DNA repair pathway enhances the error-prone non-homologous end-joining (NHEJ) repair, leading to increased genomic instability, and that gen...

    Authors: Yan Nie, Yibo Li, Xiaoli Li, Andrew F. Wilson and Qishen Pang

    Citation: Stem Cell Research & Therapy 2019 10:114

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  34. Content type: Research

    Pluripotent stem cell-derived cardiomyocytes (PSC-CMs) are widely used models for regenerative medicine and disease research. However, PSC-CMs are usually immature in morphology and functionality and the matur...

    Authors: Rou Chen, Jun He, Yumei Wang, You Guo, Juan Zhang, Luying Peng, Duo Wang, Qin Lin, Jie Zhang, Zheng Guo and Li Li

    Citation: Stem Cell Research & Therapy 2019 10:113

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  35. Content type: Research

    New insights on cellular and molecular aspects of both oligodendrocyte (OL) differentiation and myelin synthesis pathways are potential avenues for developing a cell-based therapy for demyelinating disorders c...

    Authors: Negin Afrang, Rezvan Tavakoli, Nooshin Tasharrofi, Amir Alian, Alireza Naderi Sohi, Mahboubeh Kabiri, Mehrnoosh Fathi-Roudsari, Mina Soufizomorrod, Farzad Rajaei, Masoud Soleimani and Fatemeh Kouhkan

    Citation: Stem Cell Research & Therapy 2019 10:112

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  36. Content type: Review

    Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wo...

    Authors: Azar Nourian Dehkordi, Fatemeh Mirahmadi Babaheydari, Mohammad Chehelgerdi and Shiva Raeisi Dehkordi

    Citation: Stem Cell Research & Therapy 2019 10:111

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  37. Content type: Research

    Synthetic implants are being used to restore injured or damaged tissues following cancer resection and congenital diseases. However, the survival of large tissue implant replacements depends on their ability t...

    Authors: M. F. Griffin, N. Naderi, D. M. Kalaskar, A. M. Seifalian and P. E. Butler

    Citation: Stem Cell Research & Therapy 2019 10:110

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  38. Content type: Research

    Osteoarthritis (OA) is the most prevalent joint disease, and to date, no options for effective tissue repair and restoration are available. With the aim of developing new therapies, the impact of mesenchymal s...

    Authors: Enrico Ragni, Carlotta Perucca Orfei, Paola De Luca, Gaia Lugano, Marco Viganò, Alessandra Colombini, Federico Valli, Daniele Zacchetti, Valentina Bollati and Laura de Girolamo

    Citation: Stem Cell Research & Therapy 2019 10:109

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  39. Content type: Research

    Tendons are a crucial component of the musculoskeletal system and responsible for transmission forces derived from muscle to bone. Patients with tendon injuries are often observed with decreased collagen produ...

    Authors: Yang Liu, Lu Feng, Jia Xu, Zhengmeng Yang, Tianyi Wu, Jiajun Zhang, Liu Shi, Dahai Zhu, Jinfang Zhang and Gang Li

    Citation: Stem Cell Research & Therapy 2019 10:108

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  40. Content type: Research

    Intrauterine adhesion (IUA) is characterized by progressive intrauterine fibrosis as a consequence of trauma to the basal layer of the endometrium. In an attempt to relieve IUA, many approaches have been appli...

    Authors: Xing Chen, Jingtao Sun, Xiaoyu Li, Lele Mao, Lei Cui and Wenpei Bai

    Citation: Stem Cell Research & Therapy 2019 10:107

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  41. Content type: Research

    Human adipose-derived stem cells (hADSCs) are an important source of cells for regenerative medicine. Evidence of extensive interactions with the surrounding microenvironment has led researchers to focus more ...

    Authors: Fen Xu, Qinqin Xiang, Jiuzuo Huang, Qianlong Chen, Nanze Yu, Xiao Long and Zhou Zhou

    Citation: Stem Cell Research & Therapy 2019 10:106

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  42. Content type: Research

    Preterm newborns are at high risk of developing neurodevelopmental deficits caused by neuroinflammation leading to perinatal brain injury. Human Wharton’s jelly mesenchymal stem cells (hWJ-MSC) derived from th...

    Authors: Gierin Thomi, Daniel Surbek, Valérie Haesler, Marianne Joerger-Messerli and Andreina Schoeberlein

    Citation: Stem Cell Research & Therapy 2019 10:105

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  43. Content type: Research

    Putative endothelial progenitor cells (pEPCs) have been confirmed to participate in alleviation of renal fibrosis in several ischaemic diseases. However, their mechanistic effect on renal fibrosis, which is ch...

    Authors: Juan Yang, Meng Wang, Fengming Zhu, Jie Sun, Huzi Xu, Octavia Li-Sien Chong Lee Shin, Zhi Zhao, Guangchang Pei, Han Zhu, Chujin Cao, Xiaofeng He, Yi Huang, Zufu Ma, Liu Liu, Le Wang, Yong Ning…

    Citation: Stem Cell Research & Therapy 2019 10:104

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  44. Content type: Research

    Premature ovarian insufficiency is a common complication of anticancer treatments in young women and girls. The ovary is a complex, highly regulated reproductive organ, whose proper function is contingent upon...

    Authors: Lisa J. Green, Hong Zhou, Vasantha Padmanabhan and Ariella Shikanov

    Citation: Stem Cell Research & Therapy 2019 10:102

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  45. Content type: Research

    The ex vivo expansion potential of mesenchymal stromal/stem cells (MSC) together with their differentiation and secretion properties makes these cells an attractive tool for transplantation and tissue engineer...

    Authors: Elisabetta Manuela Foppiani, Olivia Candini, Ilenia Mastrolia, Alba Murgia, Giulia Grisendi, Anna Valeria Samarelli, Giulia Boscaini, Lucrezia Pacchioni, Massimo Pinelli, Giorgio De Santis, Edwin M. Horwitz, Elena Veronesi and Massimo Dominici

    Citation: Stem Cell Research & Therapy 2019 10:101

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  46. Content type: Research

    Primary mesenchymal stem cells (MSCs) are fraught with aging-related shortfalls. Human-induced pluripotent stem cell (iPSC)-derived MSCs (iMSCs) have been shown to be a useful clinically relevant source of MSC...

    Authors: Lucas-Sebastian Spitzhorn, Matthias Megges, Wasco Wruck, Md Shaifur Rahman, Jörg Otte, Özer Degistirici, Roland Meisel, Rüdiger Volker Sorg, Richard O. C. Oreffo and James Adjaye

    Citation: Stem Cell Research & Therapy 2019 10:100

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  47. Content type: Research

    The manufacture of mesenchymal stem/stromal cells (MSCs) for clinical use needs to be cost effective, safe and scaled up. Current methods of expansion on tissue culture plastic are labour-intensive and involve...

    Authors: Claire Mennan, John Garcia, Sally Roberts, Charlotte Hulme and Karina Wright

    Citation: Stem Cell Research & Therapy 2019 10:99

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  48. Content type: Research

    Mesenchymal stem cells (MSCs) are increasingly being applied as a therapy for liver fibrosis. Exosomes possess similar functions to their parent cells; however, they are safe and effective cell-free reagents w...

    Authors: Xiaoli Rong, Junzhi Liu, Xia Yao, Tiechao Jiang, Yimin Wang and Feng Xie

    Citation: Stem Cell Research & Therapy 2019 10:98

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