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  1. Research

    The similarities between smDCs and regDCs in alleviating the immune injury caused by transplantation of hepatocytes differentiated from ESCs

    This study aimed to investigate the tolerogenic mechanisms induced by semimature dendritic cells (smDCs) and regulatory dendritic cells (regDCs) after transplantation of hepatocytes differentiated from mouse e...

    Cheng Zhang, Wenwei Liao, Bing Cai, Furong Liu, Qiong Ke, Xiaofeng Zhu, Xiaoshun He and Anbin Hu

    Stem Cell Research & Therapy 2017 8:266

    Published on: 21 November 2017

  2. Research

    Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice

    Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HS...

    Pasupathi Sundaramoorthy, Qinhong Wang, Zhihong Zheng, Yiqun Jiao, Benny J. Chen, Phuong L. Doan, Nelson J. Chao and Yubin Kang

    Stem Cell Research & Therapy 2017 8:263

    Published on: 15 November 2017

  3. Research

    Autologous adipose-derived regenerative cell therapy modulates development of hypertrophic scarring in a red Duroc porcine model

    Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that ...

    Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus and John K. Fraser

    Stem Cell Research & Therapy 2017 8:261

    Published on: 15 November 2017

  4. Research

    Pellet coculture of osteoarthritic chondrocytes and infrapatellar fat pad-derived mesenchymal stem cells with chitosan/hyaluronic acid nanoparticles promotes chondrogenic differentiation

    Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. T...

    Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang and Cheng Chen

    Stem Cell Research & Therapy 2017 8:264

    Published on: 15 November 2017

  5. Research

    Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study

    Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage...

    Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E. Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee and In-Bo Han

    Stem Cell Research & Therapy 2017 8:262

    Published on: 15 November 2017

  6. Research

    Substance P and patterned silk biomaterial stimulate periodontal ligament stem cells to form corneal stroma in a bioengineered three-dimensional model

    We aimed to generate a bioengineered multi-lamellar human corneal stroma tissue in vitro by differentiating periodontal ligament stem cells (PDLSCs) towards keratocytes on an aligned silk membrane.

    Jialin Chen, Wei Zhang, Peyman Kelk, Ludvig J. Backman and Patrik Danielson

    Stem Cell Research & Therapy 2017 8:260

    Published on: 13 November 2017

  7. Research

    Therapeutic effects of bone marrow-derived mononuclear cells from healthy or silicotic donors on recipient silicosis mice

    Administration of bone marrow mononuclear cells (BMMCs) modulates lung inflammation and fibrosis in experimental silicosis. However, no studies have evaluated whether silicosis affects the efficacy of autologo...

    Helena D’Anunciação de Oliveira, Elga Bernardo Bandeira de Melo, Johnatas Dutra Silva, Jamil Zola Kitoko, Bianca Gutfilen, Thiago Barboza, Sergio Augusto Lopes de Souza, Christina Maeda Takiya, Patricia Rieken Macedo Rocco, Miquéias Lopes-Pacheco and Marcelo Marcos Morales

    Stem Cell Research & Therapy 2017 8:259

    Published on: 10 November 2017

  8. Research

    TGFβ3 recruits endogenous mesenchymal stem cells to initiate bone regeneration

    The recruitment of a sufficient number of endogenous mesenchymal stem cells (MSCs) is the first stage of in-situ tissue regeneration. Transforming growth factor beta-3 (TGFβ3) could recruit stem or progenitor ...

    Moyuan Deng, Tieniu Mei, Tianyong Hou, Keyu Luo, Fei Luo, Aijun Yang, Bo Yu, Hao Pang, Shiwu Dong and Jianzhong Xu

    Stem Cell Research & Therapy 2017 8:258

    Published on: 10 November 2017

  9. Research

    Human amnion cells reverse acute and chronic pulmonary damage in experimental neonatal lung injury

    Despite advances in neonatal care, bronchopulmonary dysplasia (BPD) remains a significant contributor to infant mortality and morbidity. While human amnion epithelial cells (hAECs) have shown promise in small ...

    Dandan Zhu, Jean Tan, Amina S. Maleken, Ruth Muljadi, Siow T. Chan, Sin N. Lau, Kirstin Elgass, Bryan Leaw, Joanne Mockler, Daniel Chambers, Kristen T. Leeman, Carla F. Kim, Euan M. Wallace and Rebecca Lim

    Stem Cell Research & Therapy 2017 8:257

    Published on: 10 November 2017

  10. Research

    Poly(ethylene glycol)-modified silk fibroin membrane as a carrier for limbal epithelial stem cell transplantation in a rabbit LSCD model

    Limbal epithelial stem cells (LESCs) play important roles in corneal epithelial homeostasis and regeneration, and damage to the limbus will lead to limbal stem cell deficiency (LSCD), with conjunctivalization ...

    Yijian Li, Yuli Yang, Lei Yang, Yuxiao Zeng, Xiaowei Gao and Haiwei Xu

    Stem Cell Research & Therapy 2017 8:256

    Published on: 7 November 2017

  11. Research

    Regenerative potential of primary adult human neural stem cells on micropatterned bio-implants boosts motor recovery

    The adult brain is unable to regenerate itself sufficiently after large injuries. Therefore, hopes rely on therapies using neural stem cell or biomaterial transplantation to sustain brain reconstruction. The a...

    Carole Davoust, Benjamin Plas, Amélie Béduer, Boris Demain, Anne-Sophie Salabert, Jean Christophe Sol, Christophe Vieu, Laurence Vaysse and Isabelle Loubinoux

    Stem Cell Research & Therapy 2017 8:253

    Published on: 7 November 2017

  12. Research

    miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo

    Endometriosis is a common, benign, and estrogen-dependent disease characterized by pelvic pain and infertility. To date, the pathogenesis of endometriosis remains unclear. Recent studies have demonstrated that...

    Zongwen Liang, Yijie Chen, Yuan Zhao, Chaoyi Xu, Anqi Zhang, Qiong Zhang, Danhan Wang, Jing He, Wenfeng Hua and Ping Duan

    Stem Cell Research & Therapy 2017 8:251

    Published on: 7 November 2017

  13. Research

    Adjudin-preconditioned neural stem cells enhance neuroprotection after ischemia reperfusion in mice

    Transplantation of neural stem cells (NSCs) has been proposed as a promising therapeutic strategy for the treatment of ischemia/reperfusion (I/R)-induced brain injury. However, existing evidence has also chall...

    Tingting Zhang, Xiao Yang, Tengyuan Liu, Jiaxiang Shao, Ningzhen Fu, Aijuan Yan, Keyi Geng and Weiliang Xia

    Stem Cell Research & Therapy 2017 8:248

    Published on: 7 November 2017

  14. Research

    Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment

    Several studies have suggested that caffeic acid phenethyl ester (CAPE) can induce the expression of hypoxia inducible factor-1α (HIF-1α) protein. We determined whether CAPE has a novel function in improving t...

    Xiaofang Chen, Yi Han, Bowen Zhang, Yiming Liu, Sihan Wang, Tuling Liao, Ziliang Deng, Zeng Fan, Jing Zhang, Lijuan He, Wen Yue, Yanhua Li and Xuetao Pei

    Stem Cell Research & Therapy 2017 8:255

    Published on: 7 November 2017

  15. Research

    Cancer cell-soluble factors reprogram mesenchymal stromal cells to slow cycling, chemoresistant cells with a more stem-like state

    Mesenchymal stem cells (MSCs) play different roles in modulating tumor progression, growth, and metastasis. MSCs are recruited to the tumor site in large numbers and subsequently have an important microenviron...

    Ahmed El-Badawy, Mohamed A. Ghoneim, Mahmoud M. Gabr, Radwa Ayman Salah, Ihab K. Mohamed, Marwa Amer and Nagwa El-Badri

    Stem Cell Research & Therapy 2017 8:254

    Published on: 7 November 2017

  16. Research

    Connexin 32 and connexin 43 are involved in lineage restriction of hepatic progenitor cells to hepatocytes

    Bi-potential hepatic progenitor cells can give rise to both hepatocytes and cholangiocytes, which is the last phase and critical juncture in terms of sequentially hepatic lineage restriction from any kind of s...

    Haiyun Pei, Chao Zhai, Huilin Li, Fang Yan, Jinhua Qin, Hongfeng Yuan, Rui Zhang, Shuyong Wang, Wencheng Zhang, Mingyang Chang, Yunfang Wang and Xuetao Pei

    Stem Cell Research & Therapy 2017 8:252

    Published on: 7 November 2017

  17. Short report

    Single cell transcriptomics suggest that human adipocyte progenitor cells constitute a homogeneous cell population

    Regulation of adipose tissue stem cells (ASCs) and adipogenesis impact the development of excess body fat-related metabolic complications. Animal studies have suggested the presence of distinct subtypes of ASC...

    Juan R. Acosta, Simon Joost, Kasper Karlsson, Anna Ehrlund, Xidan Li, Myriam Aouadi, Maria Kasper, Peter Arner, Mikael Rydén and Jurga Laurencikiene

    Stem Cell Research & Therapy 2017 8:250

    Published on: 7 November 2017

  18. Research

    Human iPSC-derived chondrocytes mimic juvenile chondrocyte function for the dual advantage of increased proliferation and resistance to IL-1β

    Induced pluripotent stem cells (iPSC) provide an unlimited patient-specific cell source for regenerative medicine. Adult cells have had limited success in cartilage repair, but juvenile chondrocytes (from dono...

    Jieun Lee, Piera Smeriglio, Constance R. Chu and Nidhi Bhutani

    Stem Cell Research & Therapy 2017 8:244

    Published on: 2 November 2017

  19. Research

    Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance by suppressing NLRP3 inflammasome-mediated inflammation in type 2 diabetes rats

    Insulin resistance is one of the most common and important pathological features of type 2 diabetes (T2D). Recently, insulin resistance is increasingly considered to be associated with systemic chronic inflamm...

    Xiaoya Sun, Haojie Hao, Qingwang Han, Xiaoyan Song, Jiejie Liu, Liang Dong, Weidong Han and Yiming Mu

    Stem Cell Research & Therapy 2017 8:241

    Published on: 2 November 2017

  20. Research

    Galectin-1 and galectin-3 expression in equine mesenchymal stromal cells (MSCs), synovial fibroblasts and chondrocytes, and the effect of inflammation on MSC motility

    Mesenchymal stromal cells (MSCs) can be used intra-articularly to quell inflammation and promote cartilage healing; however, mechanisms by which MSCs mitigate joint disease remain poorly understood. Galectins,...

    Heidi L. Reesink, Ryan M. Sutton, Carolyn R. Shurer, Ryan P. Peterson, Julie S. Tan, Jin Su, Matthew J. Paszek and Alan J. Nixon

    Stem Cell Research & Therapy 2017 8:243

    Published on: 2 November 2017

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