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  1. Content type: Research

    To explore the mechanism of human umbilical cord-derived mesenchymal stem cell (hUMSC) transplantation to improve ovarian function and the endometrial receptivity in autoimmune premature ovarian failure (POF) ...

    Authors: Xueyan Lu, Jingjing Cui, Linlu Cui, Qianqian Luo, Qizhi Cao, Wendan Yuan and Hongqin Zhang

    Citation: Stem Cell Research & Therapy 2019 10:214

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  2. Content type: Research

    As the representative of fenamic acids, an important group of NSAIDs, flufenamic acid (FFA) has been used for anti-inflammation and analgesia in the clinic. Recently, researches have focused on the role of som...

    Authors: Xuenan Liu, Zheng Li, Hao Liu, Yuan Zhu, Dandan Xia, Siyi Wang, Ranli Gu, Weiliang Wu, Ping Zhang, Yunsong Liu and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2019 10:213

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  3. Content type: Research

    Over 50% of acute stroke patients have hyperglycemia, which is associated with a poorer prognosis and outcome. Our aim was to investigate the impact of hyperglycemia on behavioral recovery and brain repair of ...

    Authors: Mari Carmen Gómez-de Frutos, Fernando Laso-García, Luke Diekhorst, Laura Otero-Ortega, Blanca Fuentes, Jukka Jolkkonen, Olivier Detante, Anaick Moisan, Arturo Martínez-Arroyo, Exuperio Díez-Tejedor and María Gutiérrez-Fernández

    Citation: Stem Cell Research & Therapy 2019 10:212

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  4. Content type: Research

    Autosomal recessive osteopetrosis is a genetically and phenotypically heterogeneous disease, caused by defects in osteoclast formation and function. The only available treatment is allogeneic stem cell transpl...

    Authors: Fatma Visal Okur, İnci Cevher, Cansu Özdemir, Çetin Kocaefe and Duygu Uçkan Çetinkaya

    Citation: Stem Cell Research & Therapy 2019 10:211

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  5. Content type: Research

    The paradigm of hematopoietic stem and progenitor cells (HSPCs) has become accepted ever since the discovery of adult mouse liver hematopoietic stem cells and their multipotent characteristics that give rise t...

    Authors: Yuhong Qin, Keke Fang, Nan Lu, Yuan Hu, Zhigang Tian and Cai Zhang

    Citation: Stem Cell Research & Therapy 2019 10:210

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  6. Content type: Research

    Definitive treatment strategies for bisphosphonate-related osteonecrosis of the jaw (BRONJ) have not been developed. Cell-based therapy is an attractive treatment method for intractable diseases in the medical...

    Authors: Shinichiro Kuroshima, Kazunori Nakajima, Muneteru Sasaki, Takashi I, Yoshinori Sumita, Takayuki Asahara, Izumi Asahina and Takashi Sawase

    Citation: Stem Cell Research & Therapy 2019 10:209

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  7. Content type: Research

    Stem cell therapy has revealed a promising future for treating erectile dysfunction (ED), but the fate and curative mechanism of intracavernosal transplanted stem cells are under further exploration. This stud...

    Authors: Hai-Bo Zhang, Feng-Zhi Chen, Shu-Hua He, Yan-Bing Liang, Zhi-Qiang Wang, Li Wang, Ze-Rong Chen, Wei Ding, Shan-Chao Zhao and An-Yang Wei

    Citation: Stem Cell Research & Therapy 2019 10:208

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  8. Content type: Research

    The goals of this study were to explore the expression profiles and functional networks of long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) in mesenchymal stromal cells (MSCs) involved in regulating t...

    Authors: Ming Li, Zhongyu Xie, Zhaopeng Cai, Fang Su, Guan Zheng, Jinteng Li, Shan Wang, Shuizhong Cen, Wenjie Liu, Su’an Tang, Guiwen Ye, Zhaofeng Li, Rujia Mi, Yiqian Pan, Peng Wang, Yanfeng Wu…

    Citation: Stem Cell Research & Therapy 2019 10:207

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  9. Content type: Correction

    The original article [1] displayed a co-author, Junbo Ge who has since stated that he should not have been a co-author in the article; the article has now been amended to remove Junbo Ge accordingly. All autho...

    Authors: Mengkang Fan, Yin Huang, Zhangwei Chen, Yan Xia, Ao Chen, Danbo Lu, Yuan Wu, Ning Zhang and Juying Qian

    Citation: Stem Cell Research & Therapy 2019 10:206

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    The original article was published in Stem Cell Research & Therapy 2019 10:150

  10. Content type: Research

    Chronic consumption of most drugs of abuse leads to brain oxidative stress and neuroinflammation, which inhibit the glutamate transporter GLT-1, proposed to perpetuate drug intake. The present study aimed at i...

    Authors: María Elena Quintanilla, Fernando Ezquer, Paola Morales, Daniela Santapau, Pablo Berríos-Cárcamo, Marcelo Ezquer, Mario Herrera-Marschitz and Yedy Israel

    Citation: Stem Cell Research & Therapy 2019 10:205

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  11. Content type: Research

    Endometrial regenerative cells (ERCs) are a new type of mesenchymal-like stromal cells, and their therapeutic potential has been tested in a variety of disease models. SDF-1/CXCR4 axis plays a chemotaxis role ...

    Authors: Xiang Li, Xu Lan, Yiming Zhao, Grace Wang, Ganggang Shi, Hongyue Li, Yonghao Hu, Xiaoxi Xu, Baoren Zhang, Kui Ye, Xiangying Gu, Caigan Du and Hao Wang

    Citation: Stem Cell Research & Therapy 2019 10:204

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  12. Content type: Research

    Friedreich’s ataxia (FRDA) is an autosomal recessive disease caused by a non-coding mutation in the first intron of the frataxin (FXN) gene that suppresses its expression. Compensatory hypertrophic cardiomyopathy...

    Authors: Andy On-Tik Wong, Gabriel Wong, Michael Shen, Maggie Zi-Ying Chow, Wan Wai Tse, Bimal Gurung, Suet Yee Mak, Deborah K. Lieu, Kevin D. Costa, Camie W. Chan, Alain Martelli, Joseph F. Nabhan and Ronald A. Li

    Citation: Stem Cell Research & Therapy 2019 10:203

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  13. Content type: Research

    By post-transcriptionally regulating multiple target transcripts, microRNAs (miRNAs or miR) play important biological functions. H1 embryonic stem cells (hESCs) and NTera-2 embryonal carcinoma cells (ECCs) are...

    Authors: Ildercílio Mota de Souza Lima, Josiane Lilian dos Santos Schiavinato, Sarah Blima Paulino Leite, Danuta Sastre, Hudson Lenormando de Oliveira Bezerra, Bruno Sangiorgi, Amanda Cristina Corveloni, Carolina Hassibe Thomé, Vitor Marcel Faça, Dimas Tadeu Covas, Marco Antônio Zago, Mauro Giacca, Miguel Mano and Rodrigo Alexandre Panepucci

    Citation: Stem Cell Research & Therapy 2019 10:202

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  14. Content type: Research

    The meniscus tear is one of the most common knee injuries particularly seen in athletes and aging populations. Subchondral bone sclerosis, irreparable joint damage, and the early onset of osteoarthritis make t...

    Authors: Feng Liu, Hongyao Xu and He Huang

    Citation: Stem Cell Research & Therapy 2019 10:201

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  15. Content type: Research

    Follicle depletion is one of the causes of premature ovarian failure (POF) and primary ovarian insufficiency (POI). Hence, maintenance of a certain number of female germline stem cells (FGSCs) is optimal to pr...

    Authors: Yu Jiang, Dantian Zhu, Wenfeng Liu, Qiushi Qin, Zhi Fang and Zezheng Pan

    Citation: Stem Cell Research & Therapy 2019 10:198

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  16. Content type: Review

    Adipose-derived stem cells (ASCs) are promising therapeutic cells for ischemic heart diseases, due to the ease and efficiency of acquisition, the potential of myocardial lineage differentiation, and the paracr...

    Authors: Xiaoting Li, Teng Ma, Jiacheng Sun, Mingjing Shen, Xiang Xue, Yongbing Chen and Zhiwei Zhang

    Citation: Stem Cell Research & Therapy 2019 10:196

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  17. Content type: Research

    Recent progress in the induced generation of dopaminergic (DA) neurons from different types of stem cells or reprogrammed somatic cells holds tremendous potential for the treatment of Parkinson’s disease (PD)....

    Authors: Hao Yang, Dingjun Hao, Cheng Liu, Dageng Huang, Bo Chen, Hong Fan, Cuicui Liu, Lingling Zhang, Qian Zhang, Jing An and Jingjing Zhao

    Citation: Stem Cell Research & Therapy 2019 10:195

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  18. Content type: Review

    Exosomes are bilayer membrane vesicles with cargos that contain a variety of surface proteins, markers, lipids, nucleic acids, and noncoding RNAs. Exosomes from different cardiac cells participate in the proce...

    Authors: Ming-yue Xu, Zhi-shuai Ye, Xian-tao Song and Rong-chong Huang

    Citation: Stem Cell Research & Therapy 2019 10:194

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  19. Content type: Research

    Pigs have emerged as one of the most popular large animal models in biomedical research, which in many cases is considered as a superior choice over rodent models. In addition, transplantation studies using pi...

    Authors: Junjun Xu, Leqian Yu, Jianxiong Guo, Jinzhu Xiang, Zheng Zheng, Dengfeng Gao, Bingbo Shi, Haiyang Hao, Deling Jiao, Liang Zhong, Yu Wang, Jun Wu, Hongjiang Wei and Jianyong Han

    Citation: Stem Cell Research & Therapy 2019 10:193

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  20. Content type: Research

    The use of mesenchymal stem cells (MSCs) is being extensively studied in clinical trials in the setting of various diseases including diabetes, stroke, and progressive multiple sclerosis. The unique immunomodu...

    Authors: Caroline Laroye, Amir Boufenzer, Lucie Jolly, Lisiane Cunat, Corentine Alauzet, Jean-Louis Merlin, Clémence Yguel, Danièle Bensoussan, Loïc Reppel and Sébastien Gibot

    Citation: Stem Cell Research & Therapy 2019 10:192

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  21. Content type: Research

    WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. ...

    Authors: Maryam Kay, Bahram Mohammad Soltani, Fahimeh Hosseini Aghdaei, Hassan Ansari and Hossein Baharvand

    Citation: Stem Cell Research & Therapy 2019 10:191

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  22. Content type: Research

    There is an urgent need for targeted biological therapies for prostate cancer with greater efficacy and less toxicity, particularly for metastatic disease, where current therapies are not curative. Therapeutic...

    Authors: Tahir Muhammad, Ali Sakhawat, Aamir Ali Khan, Ling Ma, Ruth A. Gjerset and Yinghui Huang

    Citation: Stem Cell Research & Therapy 2019 10:190

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  23. Content type: Research

    Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful t...

    Authors: Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue and Zhijun Pan

    Citation: Stem Cell Research & Therapy 2019 10:189

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  24. Content type: Research

    Feline adipose-derived mesenchymal stem cells (ASCs) have been successfully used in clinical trials for the treatment of immune-mediated diseases with T cell dysregulation. However, the immunomodulatory pathwa...

    Authors: Nopmanee Taechangam, Smita S. Iyer, Naomi J. Walker, Boaz Arzi and Dori L. Borjesson

    Citation: Stem Cell Research & Therapy 2019 10:188

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  25. Content type: Research

    Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissues. However, in order to evaluate the therapeutic activity of MSC, cell tracking techniques are r...

    Authors: Anna Andrzejewska, Anna Jablonska, Martyna Seta, Sylwia Dabrowska, Piotr Walczak, Miroslaw Janowski and Barbara Lukomska

    Citation: Stem Cell Research & Therapy 2019 10:187

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  26. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) derived from human embryonic stem cells (hESCs) are attractive for their hematopoietic-supporting or potential therapeutic effects. However, procedures for high-effective ...

    Authors: Yimeng Wei, Huixing Hou, Leisheng Zhang, Nianhuan Zhao, Chengwen Li, Jiali Huo, Ying Liu, Wenxia Zhang, Zongjin Li, Dengke Liu, Zhibo Han, Lei Zhang, Baoquan Song, Ying Chi and Zhongchao Han

    Citation: Stem Cell Research & Therapy 2019 10:186

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  27. Content type: Research

    Disease modeling with patient-derived induced pluripotent stem cells (iPSCs) is a powerful tool for elucidating the mechanisms underlying disease pathogenesis and developing safe and effective treatments. Pati...

    Authors: Takashi Okumura, Yumi Horie, Chen-Yi Lai, Huan-Ting Lin, Hirofumi Shoda, Bunki Natsumoto, Keishi Fujio, Eri Kumaki, Tsubasa Okano, Shintaro Ono, Kay Tanita, Tomohiro Morio, Hirokazu Kanegane, Hisanori Hasegawa, Fumitaka Mizoguchi, Kimito Kawahata…

    Citation: Stem Cell Research & Therapy 2019 10:185

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  28. Content type: Research

    Our group has developed a novel method for spontaneous spheroid formation using a specific low-adherence culture plate with around 90° water contact angle. In this study, this method was applied for oral mucos...

    Authors: Ni Li, Xianqi Li, Kai Chen, Hongwei Dong and Hideaki Kagami

    Citation: Stem Cell Research & Therapy 2019 10:184

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  29. Content type: Research

    Evidence has suggested that human adipose-derived stem cells (hADSCs) and low-level laser has neuroprotective effects on spinal cord injury (SCI). Therefore, the combined effect of the hADSCs and laser on neur...

    Authors: Arash Sarveazad, Atousa Janzadeh, Gholamreza Taheripak, Sima Dameni, Mahmoud Yousefifard and Farinaz Nasirinezhad

    Citation: Stem Cell Research & Therapy 2019 10:183

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  30. Content type: Review

    The use and effectiveness of hematopoietic stem cell transplantation (HSCT) are limited by lethal complications, i.e., acute and chronic graft-versus-host disease (aGVHD and cGVHD, respectively), in which immu...

    Authors: Lu Zhao, Shanquan Chen, Panxin Yang, Hongcui Cao and Lanjuan Li

    Citation: Stem Cell Research & Therapy 2019 10:182

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  31. Content type: Research

    Radiation exposure negatively affects the regenerative ability and makes reconstruction of bone defects after tumor section difficult. miR-34a is involved in radiation biology and bone metabolism. The aim of t...

    Authors: Huan Liu, Yan Dong, Xiaoke Feng, Liya Li, Yang Jiao, Shizhu Bai, Zhihong Feng, Hao Yu, Xuejian Li and Yimin Zhao

    Citation: Stem Cell Research & Therapy 2019 10:180

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  32. Content type: Research

    Disruptions of angiogenesis can have a significant effect on the healing of uterine scars. Human endometrial perivascular cells (CD146+PDGFRβ+) function as stem cells in the endometrium. Cysteine-rich angiogen...

    Authors: Zhongxun Li, Guijun Yan, Qiang Diao, Fei Yu, Xin’an Li, Xiaoqiang Sheng, Yong Liu, Yimin Dai, Huaijun Zhou, Xin Zhen, Yali Hu, Bruno Péault, Lijun Ding, Haixiang Sun and Hairong Li

    Citation: Stem Cell Research & Therapy 2019 10:179

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  33. Content type: Research

    Equine metabolic syndrome (EMS) refers to a cluster of associated abnormalities and metabolic disorders, including insulin resistance and adiposity. The numerous biological properties of mesenchymal stem cells...

    Authors: Lynda Bourebaba, Fatiha Bedjou, Michael Röcken and Krzysztof Marycz

    Citation: Stem Cell Research & Therapy 2019 10:178

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  34. Content type: Research

    Human decidual stromal cells (DSCs) are involved in the maintenance and development of pregnancy, in which they play a key role in the induction of immunological maternal–fetal tolerance. Precursors of DSCs (p...

    Authors: Raquel Muñoz-Fernández, Claudia De La Mata, Francisco Requena, Francisco Martín, Pablo Fernandez-Rubio, Tatiana Llorca, Maria José Ruiz-Magaña, Carmen Ruiz-Ruiz and Enrique G. Olivares

    Citation: Stem Cell Research & Therapy 2019 10:177

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  35. Content type: Research

    Molecular mechanisms underlying the regenerative process induced by stem cells in tissue-engineered urinary bladder are poorly explained. The study was performed to explore the pathways associated with regener...

    Authors: Marta Pokrywczynska, Marta Rasmus, Arkadiusz Jundzill, Daria Balcerczyk, Jan Adamowicz, Karolina Warda, Lukasz Buchholz and Tomasz Drewa

    Citation: Stem Cell Research & Therapy 2019 10:176

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  36. Content type: Research

    Cancer stem cells (CSCs) play a critical role in tumor development and progression and are involved in cancer metastasis. The role of reactive oxygen species (ROS) in CSCs and cancer metastasis remains controv...

    Authors: Caihua Wang, Liming Shao, Chi Pan, Jun Ye, Zonghui Ding, Jia Wu, Qin Du, Yuezhong Ren and Chunpeng Zhu

    Citation: Stem Cell Research & Therapy 2019 10:175

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  37. Content type: Research

    Our previous study proved that nanofat could enhance fat graft survival by promoting neovascularization. Fat extract (FE), a cell-free component derived from nanofat, also possesses proangiogenic activity.

    Authors: Hongjie Zheng, Ziyou Yu, Mingwu Deng, Yizuo Cai, Xiangsheng Wang, Yuda Xu, Lu Zhang, Wenjie Zhang and Wei Li

    Citation: Stem Cell Research & Therapy 2019 10:174

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  38. Content type: Research

    Hematopoietic stem cell (HSC) transplantation has been widely applied to the treatment of malignant blood diseases. However, limited number of functional HSCs hinders successful transplantation. The purpose of...

    Authors: Yu Zhang, Bin Shen, Xin Guan, Meng Qin, Zhihua Ren, Yupo Ma, Wei Dai, Xinxin Ding and Yongping Jiang

    Citation: Stem Cell Research & Therapy 2019 10:173

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  39. Content type: Research

    Clinically, for stem cell-based therapy (SCBT), autologous stem cells are considered better than allogenic stem cells because of little immune rejection and no risk of communicable disease infection. However, ...

    Authors: Anyuan Shi, Aerali Heinayati, Dongyu Bao, Huifen Liu, Xiaochen Ding, Xin Tong, Liudi Wang, Bin Wang and Haiyan Qin

    Citation: Stem Cell Research & Therapy 2019 10:172

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  40. Content type: Research

    Administration of the iron chelator deferasirox (DFX) in transfusion-dependent patients occasionally results in haematopoiesis recovery by a mechanism remaining elusive. This study aimed to investigate at a mo...

    Authors: Tiziana Tataranni, Carmela Mazzoccoli, Francesca Agriesti, Luciana De Luca, Ilaria Laurenzana, Vittorio Simeon, Vitalba Ruggieri, Consiglia Pacelli, Gerardo Della Sala, Pellegrino Musto, Nazzareno Capitanio and Claudia Piccoli

    Citation: Stem Cell Research & Therapy 2019 10:171

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  41. Content type: Research

    Due to its complex pathogenesis and low clinical cure rate, bisphosphonate-related osteonecrosis of the jaw (BRONJ) poses a substantial challenge for oral and maxillofacial surgeons. Therefore, the treatment o...

    Authors: Xiaolong Zang, Linhai He, Lu Zhao, Yang He, E. Xiao and Yi Zhang

    Citation: Stem Cell Research & Therapy 2019 10:169

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  42. Content type: Research

    Ischemic heart diseases are still a threat to human health. Human pluripotent stem cell-based transplantation exhibits great promise in cardiovascular disease therapy, including heart ischemia. The purpose of ...

    Authors: You Yu, Nianci Qin, Xing-Ai Lu, Jingjing Li, Xinglong Han, Xuan Ni, Lingqun Ye, Zhenya Shen, Weiqian Chen, Zhen-Ao Zhao, Wei Lei and Shijun Hu

    Citation: Stem Cell Research & Therapy 2019 10:167

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  43. Content type: Research

    Cell reprogramming is a promising avenue for cell-based therapies as it allows for the generation of multipotent, unipotent, or mature somatic cells without going through a pluripotent state. While the use of ...

    Authors: Jan-Eric Ahlfors, Ashkan Azimi, Rouwayda El-Ayoubi, Alexander Velumian, Ilan Vonderwalde, Cecile Boscher, Oana Mihai, Sarathi Mani, Marina Samoilova, Mohamad Khazaei, Michael G. Fehlings and Cindi M Morshead

    Citation: Stem Cell Research & Therapy 2019 10:166

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  44. Content type: Research

    Mounting evidence has shown that a novel subset of mesenchymal stem cells (MSCs) derived from human gingiva referred to as gingival mesenchymal stem cells (GMSCs) displays a greater immunotherapeutic potential...

    Authors: Jun Zhao, Julie Wang, Junlong Dang, Wangyu Zhu, Yaqiong Chen, Ximei Zhang, Junliang Xie, Bo Hu, Feng Huang, Baoqing Sun, Joseph A. Bellanti and Song Guo Zheng

    Citation: Stem Cell Research & Therapy 2019 10:165

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  45. Content type: Research

    Contrary to the minimal criteria proposed by the International Society for Cell and Gene Therapy for defining multipotent mesenchymal stromal cells (MSC), human leukocyte antigen (HLA)-DR expression is largely...

    Authors: Marta Grau-Vorster, Anita Laitinen, Johanna Nystedt and Joaquim Vives

    Citation: Stem Cell Research & Therapy 2019 10:164

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  46. Content type: Research

    Pulmonary emphysema is a major component of chronic obstructive pulmonary disease (COPD). Emphysema progression attributed not only to alveolar structure loss and pulmonary regeneration impairment, but also to...

    Authors: Ying-Wei Lan, Jing-Chan Yang, Chih-Ching Yen, Tsung-Teng Huang, Ying-Cheng Chen, Hsiao-Ling Chen, Kowit-Yu Chong and Chuan-Mu Chen

    Citation: Stem Cell Research & Therapy 2019 10:163

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