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  1. The physical factors of the extracellular matrix have a profound influence on the differentiation behavior of mesenchymal stem cells. In this study, the effect of the biophysical microenvironment on rat bone m...

    Authors: Yuchao Yang, Yanting Feng, Rongmei Qu, Qingtao Li, Dongming Rong, Tingyu Fan, Yiting Yang, Bing Sun, Zhenyu Bi, Asmat Ullah Khan, Ting Deng, Jingxing Dai and Jun Ouyang

    Citation: Stem Cell Research & Therapy 2020 11:522

    Content type: Research

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  2. In the last years, several clinical trials have proved the safety and efficacy of adipose-derived stem/stromal cells (ASC) in contrasting osteoarthritis (OA). Since ASC act mainly through paracrine mechanisms,...

    Authors: Chiara Giannasi, Stefania Niada, Cinzia Magagnotti, Enrico Ragni, Annapaola Andolfo and Anna Teresa Brini

    Citation: Stem Cell Research & Therapy 2020 11:521

    Content type: Research

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  3. Accumulating evidence indicates that mesenchymal stem cells (MSCs) exert tissue repair effects and therapeutic angiogenesis through their noncoding RNAs (ncRNAs). Our previous studies showed that MSCs derived ...

    Authors: Qin Shi, Baolan Sun, Di Wang, Yi Zhu, Xinxin Zhao, Xiaoqing Yang and Yuquan Zhang

    Citation: Stem Cell Research & Therapy 2020 11:520

    Content type: Research

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  4. Human umbilical cord mesenchymal stem cells (HUC-MSCs) present in the umbilical cord tissue are self-renewing and multipotent. They can renew themselves continuously and, under certain conditions, differentiat...

    Authors: Qixin Xie, Rui Liu, Jia Jiang, Jing Peng, Chunyan Yang, Wen Zhang, Sheng Wang and Jing Song

    Citation: Stem Cell Research & Therapy 2020 11:519

    Content type: Review

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  5. To investigate the odonto-immunomodulatory properties of dental pulp stem cell-derived small extracellular vesicles (DPSCs-sEV), which promote odontogenesis by switching macrophages toward the pro-healing M2 p...

    Authors: Jianmao Zheng, Yuanyuan Kong, Xiaoli Hu, Zhishan Li, Yaoyin Li, Yingqun Zhong, Xi Wei and Junqi Ling

    Citation: Stem Cell Research & Therapy 2020 11:517

    Content type: Research

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  6. Bone destruction is a hallmark of multiple myeloma (MM). It has been reported that proteasome inhibitors (PIs) can reduce bone resorption and increase bone formation in MM patients, but the underlying mechanis...

    Authors: Dan Zhang, Kim De Veirman, Rong Fan, Qiang Jian, Yuchen Zhang, Li Lei, Holly Evans, Yanmeng Wang, Lei Lei, Baiyan Wang, Ramone A. Williamson, Andrew Chantry, Pengcheng He, Ang Li, Hendrik De Raeve, Karin Vanderkerken…

    Citation: Stem Cell Research & Therapy 2020 11:516

    Content type: Research

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  7. Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global pandemic. The prevalence/severity of COVID-19 is higher among patients with cardiovasc...

    Authors: Youjeong Kwon, Sarath Babu Nukala, Shubhi Srivastava, Hiroe Miyamoto, Nur Izzah Ismail, Jordan Jousma, Jalees Rehman, Sang-Bing Ong, Won Hee Lee and Sang-Ging Ong

    Citation: Stem Cell Research & Therapy 2020 11:514

    Content type: Letter

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  8. The present study compared the effects of antifibrotic medications, pirfenidone, and nintedanib, with transplantation of human umbilical mesenchymal stem cells (HUMSCs) in restoring rat pulmonary fibrosis (PF).

    Authors: Kuo-An Chu, Chang-Ching Yeh, Fu-Hsien Kuo, Wen-Ren Lin, Chien-Wei Hsu, Tien-Hua Chen and Yu-Show Fu

    Citation: Stem Cell Research & Therapy 2020 11:513

    Content type: Research

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  9. Placenta-derived mesenchymal stem cells (PD-MSCs) have been highlighted as an alternative cell therapy agent that has become a next-generation stem cell treatment. Phosphatase of regenerating liver-1 (PRL-1), ...

    Authors: Jae Yeon Kim, Jong Ho Choi, Ji Hye Jun, Sohae Park, Jieun Jung, Si Hyun Bae and Gi Jin Kim

    Citation: Stem Cell Research & Therapy 2020 11:512

    Content type: Research

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  10. Mesenchymal stem cell (MSC)-derived exosomes have shown comprehensive application prospects over the years. Despite performing similar functions, exosomes from different origins present heterogeneous character...

    Authors: Zheng-gang Wang, Zhi-yi He, Shuang Liang, Qing Yang, Peng Cheng and An-min Chen

    Citation: Stem Cell Research & Therapy 2020 11:511

    Content type: Research

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  11. Stem cell therapies represent a promising tool in regenerative medicine. Considering the drawbacks of direct stem cell injections (e.g. poor cell localisation), extracellular matrix-based biomaterials (e.g. sc...

    Authors: Héctor Capella-Monsonís, Andrea De Pieri, Rita Peixoto, Stefanie Korntner and Dimitrios I. Zeugolis

    Citation: Stem Cell Research & Therapy 2020 11:510

    Content type: Research

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  12. Concomitant administration of allogeneic umbilical cord blood (UCB) infusion and erythropoietin (EPO) showed therapeutic efficacy in children with cerebral palsy (CP). However, no clinical studies have investi...

    Authors: Kyunghoon Min, Mi Ri Suh, Kye Hee Cho, Wookyung Park, Myung Seo Kang, Su Jin Jang, Sang Heum Kim, Seonkyeong Rhie, Jee In Choi, Hyun-Jin Kim, Kwang Yul Cha and MinYoung Kim

    Citation: Stem Cell Research & Therapy 2020 11:509

    Content type: Research

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  13. Mesenchymal stem cells (MSCs), including adipose-derived mesenchymal stem cells (ADSCs), have been shown to attenuate organ damage in acute respiratory distress syndrome (ARDS) and sepsis; however, the underly...

    Authors: Yukie Mizuta, Tomohiko Akahoshi, Jie Guo, Shuo Zhang, Sayoko Narahara, Takahito Kawano, Masaharu Murata, Kentaro Tokuda, Masatoshi Eto, Makoto Hashizume and Ken Yamaura

    Citation: Stem Cell Research & Therapy 2020 11:508

    Content type: Research

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  14. As the major interface between the body and the external environment, the skin is liable to various injuries. Skin injuries often lead to severe disability, and the exploration of promising therapeutic strateg...

    Authors: Jin Liu, Xinyu Qiu, Yajie Lv, Chenxi Zheng, Yan Dong, Geng Dou, Bin Zhu, Anqi Liu, Wei Wang, Jun Zhou, Siying Liu, Shiyu Liu, Bo Gao and Yan Jin

    Citation: Stem Cell Research & Therapy 2020 11:507

    Content type: Research

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  15. Mesenchymal stem cells (MSCs) play an important role in tumor progression; concomitantly, MSCs also undergo profound changes in the tumor microenvironment (TME). These changes can directly impact the applicati...

    Authors: Chenyang Wang, Jie Hu, Zheng Chen, Yifan Wang, Sinan Lu, Yuan Zhang, Yufeng Li, Yucheng Xiang, Yutian Ji, Cheng Zeng, Yuan Ding and Weilin Wang

    Citation: Stem Cell Research & Therapy 2020 11:506

    Content type: Research

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  16. Despite years of research, porcine-induced pluripotent stem cells (piPSCs) with germline chimeric capacity have not been established. Furthermore, the key transcription factors (TFs) defining the naïve state i...

    Authors: Bingbo Shi, Dengfeng Gao, Liang Zhong, Minglei Zhi, Xiaogang Weng, Junjun Xu, Junhong Li, Xuguang Du, Yanli Xin, Jie Gao, Qianqian Zhu, Suying Cao, Zhonghua Liu and Jianyong Han

    Citation: Stem Cell Research & Therapy 2020 11:505

    Content type: Research

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  17. De novo mutations (DNMs) have been implicated in the etiology of schizophrenia (SZ), a chronic debilitating psychiatric disorder characterized by hallucinations, delusions, cognitive dysfunction, and decreased...

    Authors: Edit Hathy, Eszter Szabó, Nóra Varga, Zsuzsa Erdei, Csongor Tordai, Boróka Czehlár, Máté Baradits, Bálint Jezsó, Júlia Koller, László Nagy, Mária Judit Molnár, László Homolya, Zsófia Nemoda, Ágota Apáti and János M. Réthelyi

    Citation: Stem Cell Research & Therapy 2020 11:504

    Content type: Research

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  18. Silicosis is an occupational respiratory disease caused by long-term excessive silica inhalation, which is most commonly encountered in industrial settings. Unfortunately, there is no effective therapy to dela...

    Authors: Chunjie Xu, Jing Zhao, Qiuyue Li, Lin Hou, Yan Wang, Siling Li, Fuyang Jiang, Zhonghui Zhu and Lin Tian

    Citation: Stem Cell Research & Therapy 2020 11:503

    Content type: Research

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  19. Right ventricular (RV) failure is a commonly encountered problem in patients with congenital heart disease but can also be a consequence of left ventricular disease, primary pulmonary hypertension, or RV-speci...

    Authors: Christoph Haller, Mark K. Friedberg and Michael A. Laflamme

    Citation: Stem Cell Research & Therapy 2020 11:502

    Content type: Review

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  20. Bone reconstruction in congenital craniofacial differences, which affect about 2–3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using ...

    Authors: Daniela Franco Bueno, Gerson Shigueru Kabayashi, Carla Cristina Gomes Pinheiro, Daniela Y. S. Tanikawa, Cassio Eduardo Raposo-Amaral, Diogenes Laercio Rocha, José Ricardo Muniz Ferreira, Yoichiro Shibuya, Akishige Hokugo, Reza Jarrahy, Patricia A. ZuK and Maria Rita Passos-Bueno

    Citation: Stem Cell Research & Therapy 2020 11:501

    Content type: Research

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  21. Peritendinous fibrosis represents a fibrotic healing process that usually occurs after tendon injury or surgery. This worldwide challenge hampers the functional rehabilitation and the mobility of extremities. ...

    Authors: Juehong Li, Zhixiao Yao, Hao Xiong, Haomin Cui, Xu Wang, Wei Zheng, Yun Qian and Cunyi Fan

    Citation: Stem Cell Research & Therapy 2020 11:500

    Content type: Research

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  22. Attitudes towards human embryonic stem cells (hESCs) in China have witnessed a significant shift in 2020 that can be attributed to China’s policy guidance. For ethical reasons, stricter standards are adopted t...

    Authors: Xuekai Xie, Jiajv Chen and Zhengyang Shu

    Citation: Stem Cell Research & Therapy 2020 11:499

    Content type: Viewpoint

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  23. Mesenchymal stem cells (MSCs) have important research value and broad application prospects in the cardiovascular disease. This study provides information on the latest progress, evolutionary path, frontier re...

    Authors: Chan Chen, Yang Lou, Xin-Yi Li, Zheng-Tian Lv, Lu-Qiu Zhang and Wei Mao

    Citation: Stem Cell Research & Therapy 2020 11:498

    Content type: Research

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  24. Mesenchymal stem cells (MSC) are non-haematopoietic, fibroblast-like multipotent stromal cells. In the injured pancreas, these cells are assumed to secrete growth factors and immunomodulatory molecules, which ...

    Authors: Rahul Khatri, Sybille Mazurek, Sebastian Friedrich Petry and Thomas Linn

    Citation: Stem Cell Research & Therapy 2020 11:497

    Content type: Research

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  25. Rotator cuff tears (RCTs) often require reconstructive surgery. Tendon-bone healing is critical for the outcome of rotator cuff reconstruction, but the process of tendon-bone healing is complex and difficult. ...

    Authors: Yao Huang, Bing He, Lei Wang, Bin Yuan, Hao Shu, Fucheng Zhang and Luning Sun

    Citation: Stem Cell Research & Therapy 2020 11:496

    Content type: Research

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  26. Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cell transplants have served as a cell therapy for treating retinal degenerative diseases. However, how to optimize the survival and engr...

    Authors: Liyan Ru, Nan Wu, Keyu Wei, Yuxiao Zeng, Qiyou Li, Chuanhuang Weng, Chunge Ren, Bangqi Ren, Da Huo, Yijian Li, Xisu Hu, Zuoxin Qin, Yajie Fang, Chuhong Zhu and Yong Liu

    Citation: Stem Cell Research & Therapy 2020 11:495

    Content type: Research

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  27. Diabetic foot ulcer is the most costly and complex challenge for patients with diabetes. We hereby assessed the effectiveness of different preconditioned adipose-derived mesenchymal stem cells (AD-MSCs) and ph...

    Authors: Houssein Ahmadi, Abdollah Amini, Fatemeh Fadaei Fathabady, Atarodsadat Mostafavinia, Fatemeh Zare, Roohollah Ebrahimpour-malekshah, Mustafa Neshat Ghalibaf, Matin Abrisham, Fatemehalsadat Rezaei, Richard Albright, Seyed Kamran Ghoreishi, Sufan Chien and Mohammad Bayat

    Citation: Stem Cell Research & Therapy 2020 11:494

    Content type: Research

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  28. Ex vivo production of hematopoietic stem/precursor cells (HSPCs) represents a promising versatile approach for blood disorders.

    Authors: Selami Demirci, Juan J. Haro-Mora, Alexis Leonard, Claire Drysdale, Daniela Malide, Keyvan Keyvanfar, Khaled Essawi, Raul Vizcardo, Naritaka Tamaoki, Nicholas P. Restifo, John F. Tisdale and Naoya Uchida

    Citation: Stem Cell Research & Therapy 2020 11:493

    Content type: Research

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  29. Skeletal disorders are among the leading debilitating factors affecting millions of people worldwide. The use of stem cells for tissue repair has raised many promises in various medical fields, including skele...

    Authors: Parisa Kangari, Tahereh Talaei-Khozani, Iman Razeghian-Jahromi and Mahboobeh Razmkhah

    Citation: Stem Cell Research & Therapy 2020 11:492

    Content type: Review

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  30. Fat grafting, as a standard treatment for numerous soft tissue defects, remains unpredictable and technique-dependent. Human adipose-derived stem cells (hADSCs) are promising candidates for cell-assisted thera...

    Authors: Fei Yu, Nevin Witman, Dan Yan, Siyi Zhang, Meng Zhou, Yan Yan, Qinke Yao, Feixue Ding, Bingqian Yan, Huijing Wang, Wei Fu, Yang Lu and Yao Fu

    Citation: Stem Cell Research & Therapy 2020 11:490

    Content type: Research

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  31. Over the last decades, the cancer survival rate has increased due to personalized therapies, the discovery of targeted therapeutics and novel biological agents, and the application of palliative treatments. De...

    Authors: Fiorella Rossi, Hunter Noren, Richard Jove, Vladimir Beljanski and Karl-Henrik Grinnemo

    Citation: Stem Cell Research & Therapy 2020 11:489

    Content type: Review

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  32. Generation of insulin-producing cells from human pluripotent stem cells (hPSCs) in vitro would be useful for drug discovery and cell therapy in diabetes. Three-dimensional (3D) culture is important for the acq...

    Authors: Xiaofang Liu, Jinhua Qin, Mingyang Chang, Shuyong Wang, Yali Li, Xuetao Pei and Yunfang Wang

    Citation: Stem Cell Research & Therapy 2020 11:488

    Content type: Research

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  33. Osteoporosis is a common metabolic bone disease without effective treatment. Bone marrow-derived mesenchymal stem cells (BMSCs) have the potential to differentiate into multiple cell types. Increased adipogeni...

    Authors: Guilin Chen, Yujuan Zhuo, Bo Tao, Qian Liu, Wenlong Shang, Yinxiu Li, Yuhong Wang, Yanli Li, Lei Zhang, Yanwen Fang, Xin Zhang, Zhicai Fang and Ying Yu

    Citation: Stem Cell Research & Therapy 2020 11:487

    Content type: Research

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  34. Translational studies have explored the therapeutic potential and feasibility of mesenchymal stem cells (MSCs) in several degenerative diseases; however, mechanistic studies of the function of these cells have...

    Authors: Jong Ho Choi, Jin Seok, Seung Mook Lim, Tae Hee Kim and Gi Jin Kim

    Citation: Stem Cell Research & Therapy 2020 11:486

    Content type: Research

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  35. Stroke is the leading cause of long-term motor disability and cognitive impairment. Recently, neurogenesis has become an attractive strategy for the chronic recovery of stroke. It is important to understand th...

    Authors: Zhaoli Hu, Fengying Li, Xiaoling Zhou, Feng Zhang, Linyan Huang, Bing Gu, Jiangang Shen and Suhua Qi

    Citation: Stem Cell Research & Therapy 2020 11:485

    Content type: Research

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  36. During the last years, several strategies have been made to obtain mature erythrocytes or red blood cells (RBC) from the bone marrow or umbilical cord blood (UCB). However, UCB-derived hematopoietic stem cells...

    Authors: Mohsen Ebrahimi, Mehdi Forouzesh, Setareh Raoufi, Mohammad Ramazii, Farhoodeh Ghaedrahmati and Maryam Farzaneh

    Citation: Stem Cell Research & Therapy 2020 11:483

    Content type: Review

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  37. Human dermal mesenchymal stromal cells (MSCs) expressing the ATP-binding cassette (ABC) efflux transporter ABCB5 represent an easily accessible MSC population that, based on preclinical and first-in-human data...

    Authors: Seda Ballikaya, Samar Sadeghi, Elke Niebergall-Roth, Laura Nimtz, Jens Frindert, Alexandra Norrick, Nicole Stemler, Nicole Bauer, Yvonne Rosche, Vanessa Kratzenberg, Julia Pieper, Tina Ficek, Markus H. Frank, Christoph Ganss, Jasmina Esterlechner and Mark A. Kluth

    Citation: Stem Cell Research & Therapy 2020 11:482

    Content type: Research

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  38. Human induced pluripotent stem cells (hiPSCs) offer a renewable source of cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and drug screening. However, current serum/fe...

    Authors: Ratchapong Netsrithong, Siriwal Suwanpitak, Bootsakorn Boonkaew, Kongtana Trakarnsanga, Lung-Ji Chang, Chartsiam Tipgomut, Chinnavuth Vatanashevanopakorn, Kovit Pattanapanyasat and Methichit Wattanapanitch

    Citation: Stem Cell Research & Therapy 2020 11:481

    Content type: Research

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  39. Nontraumatic osteonecrosis of the femoral head (NONFH) is a highly disabling orthopedic disease in young individuals. Plasminogen activator inhibitor 1 (PAI-1) has been reported to be positively associated wit...

    Authors: Lu Li, Yikai Wang, Xiaobing Yu, Yongming Bao, Lijia An, Xiaowei Wei, Weiting Yu, Baoyi Liu, Junlei Li, Jiahui Yang, Yan Xia, Ge Liu, Fang Cao, Xiuzhi Zhang and Dewei Zhao

    Citation: Stem Cell Research & Therapy 2020 11:480

    Content type: Research

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  40. Intrauterine adhesions (IUAs) are manifestations of endometrial fibrosis characterized by inflammation and fibrinogen aggregation in the extracellular matrix (ECM). The available therapeutic interventions for ...

    Authors: Limin Liu, Guobin Chen, Taoliang Chen, Wenjuan Shi, Haiyan Hu, Kaijing Song, Ruichun Huang, Huihua Cai and Yuanli He

    Citation: Stem Cell Research & Therapy 2020 11:479

    Content type: Research

    Published on:

  41. Our previous studies demonstrated that adipose-derived mesenchymal stromal cells (ASCs) have immunomodulatory effects that prolong allograft survival in a rodent hind-limb allotransplant model. In this study, ...

    Authors: Chien-Chang Chen, Rong-Fu Chen, Jheng-Syuan Shao, Yun-Ting Li, Yu-Chi Wang, Gerald Brandacher, Jiin-Haur Chuang and Yur-Ren Kuo

    Citation: Stem Cell Research & Therapy 2020 11:478

    Content type: Research

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  42. Idiopathic pulmonary fibrosis is a kind of diffuse interstitial lung disease, the pathogenesis of which is unclear, and there is currently a lack of good treatment to improve the survival rate. Human menstrual...

    Authors: Xin Chen, Yi Wu, Yanling Wang, Lijun Chen, Wendi Zheng, Sining Zhou, Huikang Xu, Yifei Li, Li Yuan and Charlie Xiang

    Citation: Stem Cell Research & Therapy 2020 11:477

    Content type: Research

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  43. Dentigerous cyst (DC) is a bone destructive disease and remains a challenge for clinicians. Marsupialization enables the bone to regenerate with capsule maintaining, making it a preferred therapeutic means for...

    Authors: Yejia Yu, Mengyu Li, Yuqiong Zhou, Yueqi Shi, Wenjie Zhang, Geehun Son, Jing Ge, Jun Zhao, Zhiyuan Zhang, Dongxia Ye, Chi Yang and Shaoyi Wang

    Citation: Stem Cell Research & Therapy 2020 11:476

    Content type: Research

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  44. Complex cryptoglandular perianal fistula (CPAF) is a kind of anal fistula that may cause anal incontinence after surgery. Minimally invasive surgery of anal fistula is constantly emerging. Over the past 20 yea...

    Authors: Yang Zhang, Min Ni, Chungen Zhou, Yehuang Wang, Yaxian Wang, Yang Shi, Jing Jin, Rui Zhang and Bin Jiang

    Citation: Stem Cell Research & Therapy 2020 11:475

    Content type: Research

    Published on:

  45. Small molecule compounds have been well recognized for their promising power in the generation, expansion, and maintenance of embryonic or adult stem cells. The aim of this study was to identify a novel combin...

    Authors: Morteza Zarrabi, Elaheh Afzal, Mohammad Hassan Asghari and Marzieh Ebrahimi

    Citation: Stem Cell Research & Therapy 2020 11:474

    Content type: Research

    Published on:

  46. After traumatic skeletal muscle injury, muscle healing is often incomplete and produces extensive fibrosis. The sequence of M1 and M2 macrophage accumulation and the duration of each subtype in the injured are...

    Authors: Leonardo Martins, Camila Congentino Gallo, Tâmisa Seeko Bandeira Honda, Patrícia Terra Alves, Roberta Sessa Stilhano, Daniela Santoro Rosa, Timothy Jon Koh and Sang Won Han

    Citation: Stem Cell Research & Therapy 2020 11:473

    Content type: Research

    Published on:

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