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  1. Content type: Research

    Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregna...

    Authors: Siwen Zhang, Pingping Li, Zhengwei Yuan and Jichun Tan

    Citation: Stem Cell Research & Therapy 2019 10:61

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  2. Content type: Research

    The regulatory mechanism of insulin-producing cells (IPCs) differentiation from induced pluripotent stem cells (iPSCs) in vitro is very important in the phylogenetics of pancreatic islets, the molecular pathog...

    Authors: Yang Xu, Yan Huang, Yibing Guo, Yicheng Xiong, Shajun Zhu, Liancheng Xu, Jingjing Lu, Xiaohong Li, Jian Wan, Yuhua Lu and Zhiwei Wang

    Citation: Stem Cell Research & Therapy 2019 10:59

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  3. Content type: Research

    Exosomes are nanoscale membrane vesicles secreted by both normal and cancer cells, and cancer cell-derived exosomes play an important role in the cross-talk between cancer cells and other cellular components i...

    Authors: Zhanjun Ma, Xue Cui, Li Lu, Guohu Chen, Yang Yang, Yan Hu, Yubao Lu, Zhangqi Cao, Yan Wang and Xuexi Wang

    Citation: Stem Cell Research & Therapy 2019 10:60

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  4. Content type: Review

    Mesenchymal stem/stromal cells (MSCs) delivered as cell therapy to individuals with degenerative and/or inflammatory disorders can help improve organ features and resolve inflammation, as demonstrated in precl...

    Authors: Abderrahim Naji, Benoit Favier, Frédéric Deschaseaux, Nathalie Rouas-Freiss, Masamitsu Eitoku and Narufumi Suganuma

    Citation: Stem Cell Research & Therapy 2019 10:56

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  5. Content type: Research

    Despite significant progress in drug treatment, the prognosis of patients with advanced pulmonary arterial hypertension (PAH) remains extremely poor. Many preclinical studies have reported the efficacy of stem...

    Authors: Xian-Fei Ding, Huo-Yan Liang, Bo Yuan, Li-Feng Li, Tian Wang, Quan-Cheng Kan, Le-Xin Wang and Tong-Wen Sun

    Citation: Stem Cell Research & Therapy 2019 10:55

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  6. Content type: Research

    Insulin-dependent diabetes is a multifactorial disorder that could be theoretically cured by functional pancreatic islets and insulin-producing cell (IPC) implantation. Regenerative medicine approaches include...

    Authors: Irit Meivar-Levy, Fatima Zoabi, Gil Nardini, Eugenia Manevitz-Mendelson, Gil S. Leichner, Oranit Zadok, Michael Gurevich, Eytan Mor, Simona Dima, Irinel Popescu, Aviv Barzilai, Sarah Ferber and Shoshana Greenberger

    Citation: Stem Cell Research & Therapy 2019 10:53

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  7. Content type: Research

    Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by the inflammatory environment, which changes during tissue repair. Macrophages are essential in mediating the inflammatory response afte...

    Authors: Laura Saldaña, Fátima Bensiamar, Gema Vallés, Francisco J. Mancebo, Eduardo García-Rey and Nuria Vilaboa

    Citation: Stem Cell Research & Therapy 2019 10:58

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  8. Content type: Research

    Tissue inflammation is an important problem in the field of human adipose-derived stem cell (ASC)-based therapeutic bone regeneration. Many studies indicate that inflammatory cytokines are disadvantageous for ...

    Authors: Yuejun Wang, Yunsong Liu, Min Zhang, Longwei Lv, Xiao Zhang, Ping Zhang and Yongsheng Zhou

    Citation: Stem Cell Research & Therapy 2019 10:57

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  9. Content type: Research

    Psoriasis is a chronic and systemic, immune-mediated, inflammatory disease. Mesenchymal stem cells have effects on the inflammatory microenvironment, including regulating the proliferation, differentiation, re...

    Authors: Xuping Niu, Junqing Li, Xincheng Zhao, Qiang Wang, Gang Wang, Ruixia Hou, Xinhua Li, Peng An, Guohua Yin and Kaiming Zhang

    Citation: Stem Cell Research & Therapy 2019 10:54

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  10. Content type: Correction

    The original article [1] contains an error in the legend of Fig 5 whereby the descriptions for panels 5d and 5e are incorrect; as such, the corrected legend can be viewed below with its respective figure images.

    Authors: Roni A. Hazim, Saravanan Karumbayaram, Mei Jiang, Anupama Dimashkie, Vanda S. Lopes, Douran Li, Barry L. Burgess, Preethi Vijayaraj, Jackelyn A. Alva-Ornelas, Jerome A. Zack, Donald B. Kohn, Brigitte N. Gomperts, April D. Pyle, William E. Lowry and David S. Williams

    Citation: Stem Cell Research & Therapy 2019 10:52

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    The original article was published in Stem Cell Research & Therapy 2017 8:217

  11. Content type: Review

    Mesenchymal stem cell (MSC) encapsulation technique has long been emerged in tissue engineering as it plays an important role in implantation of stem cells to regenerate a damaged tissue. MSC encapsulation pro...

    Authors: Hyerim Kim, Chaewon Bae, Yun-Min Kook, Won-Gun Koh, Kangwon Lee and Min Hee Park

    Citation: Stem Cell Research & Therapy 2019 10:51

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  12. Content type: Research

    Mesenchymal stem cells derived from the chorionic villi of human placentae (pMSCs) produce a unique array of mediators that regulate the essential cellular functions of their target cells. These properties mak...

    Authors: M. H. Abumaree, N. A. Alshehri, A. Almotery, A. M. Al Subayyil, E. Bahattab, F. M. Abomaray, T. Khatlani, B. Kalionis, D. Jawdat, M. F. El-Muzaini, M. A. Al Jumah and A. S. AlAskar

    Citation: Stem Cell Research & Therapy 2019 10:50

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  13. Content type: Research

    Bone marrow mesenchymal stem cells (BMMSCs) are suitable cell sources for dental pulp regeneration, but the mechanism of BMMSCs differentiation into odontogenic lineage remains unknown. The aim of the present ...

    Authors: Jian-mao Zheng, Yuan-yuan Kong, Yao-yin Li and Wen Zhang

    Citation: Stem Cell Research & Therapy 2019 10:48

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  14. Content type: Research

    Human adipose stem cells (ASCs) have emerged as a promising treatment paradigm for skin wounds. Recent works demonstrate that the therapeutic effect of stem cells is partially mediated by extracellular vesicle...

    Authors: Sen Ren, Jing Chen, Dominik Duscher, Yutian Liu, Guojun Guo, Yu Kang, Hewei Xiong, Peng Zhan, Yang Wang, Cheng Wang, Hans-Günther Machens and Zhenbing Chen

    Citation: Stem Cell Research & Therapy 2019 10:47

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  15. Content type: Correction

    Following publication of the original article in Stem Cell Research & Therapy [1], we would like to alert the reader that the immune-histological sections shown in Figure 2 bottom line are mistakenly the image...

    Authors: Adel Tekari, Samantha C. W. Chan, Daisuke Sakai, Sibylle Grad and Benjamin Gantenbein

    Citation: Stem Cell Research & Therapy 2019 10:49

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    The original article was published in Stem Cell Research & Therapy 2016 7:75

  16. Content type: Research

    Chemotherapy can induce premature ovarian insufficiency (POI) and reduce fertility in young female patients. Currently, there is no effective therapy for POI. Human amnion-derived mesenchymal stem cells (hAD-M...

    Authors: Li Ling, Xiushan Feng, Tianqin Wei, Yan Wang, Yaping Wang, Ziling Wang, Dongyuan Tang, Yanjing Luo and Zhengai Xiong

    Citation: Stem Cell Research & Therapy 2019 10:46

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  17. Content type: Research

    Nanosecond pulsed electric fields (nsPEFs) can produce more significant biological effects than traditional electric fields and have thus attracted rising attention in developing medical applications based on ...

    Authors: Tong Ning, Jinsong Guo, Kun Zhang, Kejia Li, Jue Zhang, Zheng Yang and Zigang Ge

    Citation: Stem Cell Research & Therapy 2019 10:45

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  18. Content type: Method

    Human embryonic stem (hES) cells serve as an invaluable tool for research and future medicine, but their transfection often leads to unwanted side effects as the method itself may induce differentiation. On th...

    Authors: Egle-Helene Ervin, Martin Pook, Indrek Teino, Valmar Kasuk, Annika Trei, Margus Pooga and Toivo Maimets

    Citation: Stem Cell Research & Therapy 2019 10:43

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  19. Content type: Review

    Mesenchymal stem cells (MSCs) have received a great deal of attention over the past 20 years mainly because of the results that showed regeneration potential and plasticity that were much stronger than expecte...

    Authors: Amanda Baracho Trindade Hill, Fabiana Fernandes Bressan, Bruce D. Murphy and Joaquim Mansano Garcia

    Citation: Stem Cell Research & Therapy 2019 10:44

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  20. Content type: Research

    Hypertrophic scars cause cosmetic and functional problems for patients, and their treatment remains challenging. Mechanical micronization of adipose tissue can remove adipocytes and concentrate functional cell...

    Authors: Jing Wang, Yunjun Liao, Jing Xia, Zijue Wang, Xiaopei Mo, Jingwei Feng, Yunfan He, Xihang Chen, Ye Li, Feng Lu and Junrong Cai

    Citation: Stem Cell Research & Therapy 2019 10:42

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  21. Content type: Research

    Although the involvement of glycoprotein non-metastatic melanomal protein B (GPNMB) in regulating the odontogenic differentiation of human dental pulp stem cells (hDPCs) has been identified, the underlying mec...

    Authors: Fengxi Liu, Xin Wang, Yun Yang, Rongrong Hu, Wenhao Wang and Yuliang Wang

    Citation: Stem Cell Research & Therapy 2019 10:35

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  22. Content type: Research

    Sertoli cells are the most important somatic cells contributing to the microenvironment (named niche) for spermatogonial stem cells (SSCs). They produce amounts of crucial growth factors and structure proteins...

    Authors: Ruhui Tian, Chencheng Yao, Chao Yang, Zijue Zhu, Chong Li, Erlei Zhi, Junlong Wang, Peng Li, Huixing Chen, Qingqing Yuan, Zuping He and Zheng Li

    Citation: Stem Cell Research & Therapy 2019 10:40

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  23. Content type: Research article

    Insulin replenishment is critical for patients with type 1 diabetes; however, current treatments such as pancreatic islet transplantation and insulin injection are not ideal. In addition to stem cell or gene t...

    Authors: Qing Fang, Min Zhai, Shan Wu, Xiaogen Hu, Zhan Hua, Huizhuo Sun, Jing Guo, Wenjian Zhang and Zai Wang

    Citation: Stem Cell Research & Therapy 2019 10:36

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  24. Content type: Research

    Hemophilia A (HA) is an X-linked recessive disorder caused by mutations in the Factor VIII (FVIII) gene leading to deficient blood coagulation. As a monogenic disorder, HA is an ideal target for cell-based gen...

    Authors: Kewa Gao, Priyadarsini Kumar, Elizabeth Cortez-Toledo, Dake Hao, Lizette Reynaga, Melanie Rose, Chuwang Wang, Diana Farmer, Jan Nolta, Jianda Zhou, Ping Zhou and Aijun Wang

    Citation: Stem Cell Research & Therapy 2019 10:34

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  25. Content type: Research

    Several studies have demonstrated that mesenchymal stem cells can ameliorate the inflammation of allergic rhinitis (AR) and correct the Th1/Th2 immune imbalance.

    Authors: Yu-Yang Dai, Si-Yang Ni, Ke Ma, Yu-Shi Ma, Zhi-Shi Wang and Xiu-Li Zhao

    Citation: Stem Cell Research & Therapy 2019 10:39

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  26. Content type: Method

    Adipogenesis is essential in in vitro experimentation to assess differentiation capability of stem cells, and therefore, its accurate measurement is important. Quantitative analysis of adipogenic levels, howev...

    Authors: Chengxiang Yuan, Smarajit Chakraborty, Krishna Kanth Chitta, Subha Subramanian, Tau En Lim, Weiping Han, K. N. Bhanu Prakash and Shigeki Sugii

    Citation: Stem Cell Research & Therapy 2019 10:38

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  27. Content type: Research

    Rehmanniae Radix is a traditional herbal medicine in East Asia that has been widely used to treat patients with osteoporosis. However, the effect of catalpol, the primary active principle component of Rehmanni...

    Authors: Yu Zhu, Yanmao Wang, Yachao Jia, Jia Xu and Yimin Chai

    Citation: Stem Cell Research & Therapy 2019 10:37

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  28. Content type: Research

    Low-intensity pulsed ultrasound (LIPUS) can induce mesenchymal stem cell (MSC) differentiation, although the mechanism of its potential effects on chondrogenic differentiation is unknown. Since autophagy is kn...

    Authors: Xiaoju Wang, Qiang Lin, Tingting Zhang, Xinwei Wang, Kai Cheng, Mingxia Gao, Peng Xia and Xueping Li

    Citation: Stem Cell Research & Therapy 2019 10:41

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  29. Content type: Correction

    The original article [1] contains a duplication error within Figure 3.

    Authors: Kang Chao, Shenghong Zhang, Yun Qiu, Xiaoyong Chen, Xiaoran Zhang, Chuang Cai, Yanwen Peng, Ren Mao, Meirav Pevsner-Fischer, Shomron Ben-horin, Eran Elinav, Zhirong Zeng, Baili Chen, Yao He, Andy Peng Xiang and Minhu Chen

    Citation: Stem Cell Research & Therapy 2019 10:33

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    The original article was published in Stem Cell Research & Therapy 2016 7:109

  30. Content type: Research

    Ell3 is a RNA polymerase II elongation factor that has various cell type-dependent functions, such as regulating the differentiation efficiency of embryonic stem cells and sensitizing cancer cells to anticance...

    Authors: Jae-Yong Lee, Soo-Hong Lee, Kwang-Soo Kim, Keun-Hong Park and Kyung-Soon Park

    Citation: Stem Cell Research & Therapy 2019 10:32

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  31. Content type: Research

    Sex differences are known to impact muscle phenotypes, metabolism, and disease risk. Skeletal muscle stem cells (satellite cells) are important for muscle repair and to maintain functional skeletal muscle. Her...

    Authors: Cajsa Davegårdh, Elin Hall Wedin, Christa Broholm, Tora Ida Henriksen, Maria Pedersen, Bente Klarlund Pedersen, Camilla Scheele and Charlotte Ling

    Citation: Stem Cell Research & Therapy 2019 10:26

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  32. Content type: Research

    Patients with diabetes mellitus (DM) often suffered with many musculoskeletal disorders, such as tendon rupture and tendinopathy. However, the understanding of the pathogenesis of these alternations is limited...

    Authors: Liu SHI, Ying-juan LI, Guang-chun DAI, Yu-cheng LIN, Gang LI, Chen WANG, Hui CHEN and Yun-feng RUI

    Citation: Stem Cell Research & Therapy 2019 10:27

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  33. Content type: Research

    Self-renewal is dependent on an intrinsic gene regulatory network centered on OCT4 and on an atypical cell cycle G1/S transition, which is also regulated by OCT4. p21, a gene negatively associated with self-re...

    Authors: Yan Lu, Huinan Qu, Da Qi, Wenhong Xu, Shutong Liu, Xiangshu Jin, Peiye Song, Yantong Guo, Yiyang Jia, Xinqi Wang, Hairi Li, Yulin Li and Chengshi Quan

    Citation: Stem Cell Research & Therapy 2019 10:28

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  34. Content type: Research

    Radiotherapy to cancer patients is inevitably accompanied by normal tissue injury, and the bone is one of the most commonly damaged tissues. Damage to bone marrow mesenchymal stem cells (BM-MSCs) induced by ra...

    Authors: Rui Zuo, Minghan Liu, Yanqiu Wang, Jie Li, Wenkai Wang, Junlong Wu, Chao Sun, Bin Li, Ziwen Wang, Weiren Lan, Chao Zhang, Chunmeng Shi and Yue Zhou

    Citation: Stem Cell Research & Therapy 2019 10:30

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  35. Content type: Research

    Fully understanding the developmental process of hepatic stem cells (HSCs) and the mechanisms of their committed differentiation is essential for optimizing the generation of functional hepatocytes for cell th...

    Authors: Jiefang Huang, Xiaonan Zhao, Jian Wang, Yiji Cheng, Qiong Wu, Bei Wang, Fang Zhao, Lijun Meng, Yanyun Zhang, Min Jin and Huanbai Xu

    Citation: Stem Cell Research & Therapy 2019 10:31

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  36. Content type: Short report

    Cognitive deficit has been identified in one third of patients affected by Duchenne Muscular Dystrophy, primarily attributed to loss of the short Dp71 dystrophin, the major brain dystrophin isoform. In this st...

    Authors: Simona Ruggieri, Luigi Viggiano, Tiziana Annese, Carmela Rubolino, Andrea Gerbino, Roberta De Zio, Patrizia Corsi, Roberto Tamma, Domenico Ribatti, Mariella Errede, Francesca Operto, Lucia Margari, Nicoletta Resta, Silvia Di Tommaso, Jessica Rosati, Maria Trojano…

    Citation: Stem Cell Research & Therapy 2019 10:29

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  37. Content type: Research

    Osteochondral injuries represent a significant clinical problem requiring novel cell-based therapies to restore function of the damaged joint with the use of mesenchymal stromal cells (MSCs) leading research e...

    Authors: Hareklea Markides, Karin J. Newell, Heike Rudorf, Lia Blokpoel Ferreras, James E. Dixon, Robert H. Morris, Martin Graves, Joshua Kaggie, Frances Henson and Alicia J. El Haj

    Citation: Stem Cell Research & Therapy 2019 10:25

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  38. Content type: Research

    Acute liver failure (ALF) is a serious threat to the life of people all over the world. Finding an effective way to manage ALF is important. Human liver stem cells (HLSCs) are early undifferentiated cells that...

    Authors: Yanzhen Bi, Jiannan Li, Yonghong Yang, Quanyi Wang, Quanquan Wang, Xiaobei Zhang, Guanjun Dong, Yibo Wang, Zhongping Duan, Zhenfeng Shu, Tongjun Liu, Yu Chen, Kai Zhang and Feng Hong

    Citation: Stem Cell Research & Therapy 2019 10:22

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  39. Content type: Research

    Liver fibrosis is a key phase that will progress to further injuries such as liver cirrhosis or carcinoma. This study aimed to investigate whether transplantation of bone marrow mesenchymal stromal cells (BM-M...

    Authors: Xiao-Yu Luo, Xiang-Jun Meng, Da-Chun Cao, Wei Wang, Kun Zhou, Lei Li, Mei Guo and Ping Wang

    Citation: Stem Cell Research & Therapy 2019 10:16

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  40. Content type: Research

    Mesenchymal stem/stromal cells (MSCs) have been widely used to treat various inflammatory diseases. The immunomodulatory capabilities of MSCs are usually licensed by inflammatory cytokines and may vary dependi...

    Authors: Xiaolei Li, Bingxue Shang, Ya-nan Li, Yufang Shi and Changshun Shao

    Citation: Stem Cell Research & Therapy 2019 10:18

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  41. Content type: Research

    Distraction osteogenesis (DO) is an effective but lengthy procedure to fully induce bone regeneration in large bone defects. Accumulating evidence supports the role of exosomes secreted by endothelial progenit...

    Authors: Yachao Jia, Yu Zhu, Shuo Qiu, Jia Xu and Yimin Chai

    Citation: Stem Cell Research & Therapy 2019 10:12

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  42. Content type: Research

    Until now, there is no effective anti-fibrotic therapy available for liver cirrhosis. Stem cell therapies have been studied for the treatment of hepatic fibrosis. However, the use of embryonic stem cells or in...

    Authors: Suhyun Park, Seon In Hwang, Jonghun Kim, Seoyeon Hwang, Sohee Kang, Sera Yang, Jonghwa Kim, Wonseok Kang, Kyun-Hwan Kim, Dong Wook Han and Yong-Han Paik

    Citation: Stem Cell Research & Therapy 2019 10:21

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  43. Content type: Research

    Cell therapy remains the most promising approach against ischemic heart injury. However, poor survival of engrafted cells in ischemic sites diminishes its therapeutic efficacy. Follistatin-like 1 (Fstl1) is do...

    Authors: Han Shen, Guanghao Cui, Yanqiong Li, Wenxue Ye, Yimin Sun, Zihan Zhang, Jingjing Li, Guiying Xu, Xiansheng Zeng, Yanxia Zhang, Wencheng Zhang, Zan Huang, Weiqian Chen and Zhenya Shen

    Citation: Stem Cell Research & Therapy 2019 10:17

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  44. Content type: Research

    Mesenchymal stem cells (MSCs) have emerged as a promising regenerative tool, owing mainly to their multi-differentiation potential and immunosuppressive capacity. When compared with MSCs classically derived fr...

    Authors: Jiao Ma, Jun Wu, Lei Han, Xiangxiang Jiang, Long Yan, Jie Hao and Hongmei Wang

    Citation: Stem Cell Research & Therapy 2019 10:19

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  45. Content type: Research

    Although the mononuclear cell (MNC) transplantation could theoretically induce therapeutic angiogenesis in the patients with no-option critical limb ischemia (NO-CLI), the clinical responses to this approach a...

    Authors: Tianyue Pan, Hao Liu, Yuan Fang, Zheng Wei, Shiyang Gu, Gang Fang, Yifan Liu, Yang Luo, Daqiao Guo, Xin Xu, Bin Chen, Junhao Jiang, Jue Yang, Zhenyu Shi, Ting Zhu, Yun Shi…

    Citation: Stem Cell Research & Therapy 2019 10:15

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  46. Content type: Research

    The uterus is a histologically dynamic organ, and the mechanisms coordinating its regeneration during the oestrous cycle and implantation are poorly understood.

    Authors: Alexandra Calle, Soraya López-Martín, Marta Monguió-Tortajada, Francesc Enric Borràs, María Yáñez-Mó and Miguel Ángel Ramírez

    Citation: Stem Cell Research & Therapy 2019 10:23

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  47. Content type: Research

    Cardiotoxicity remains an important concern in drug discovery and clinical medication. Meanwhile, Sophora tonkinensis Gapnep. (S. tonkinensis) held great value in the clinical application of traditional Chinese m...

    Authors: Ruiying Wang, Min Wang, Shan Wang, Ke Yang, Ping Zhou, Xueheng Xie, Qi Cheng, Jingxue Ye, Guibo Sun and Xiaobo Sun

    Citation: Stem Cell Research & Therapy 2019 10:20

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  48. Content type: Research

    Heterotopic ossification (HO), either acquired (aHO) or hereditary, such as fibrodysplasia ossificans progressiva (FOP), is a serious condition without effective treatment. Understanding of the core process of...

    Authors: Chen Kan, Na Ding, Jiazhao Yang, Zhenya Tan, Tammy L. McGuire, Haimei Lu, Keqin Zhang, Diana M. Palila Berger, John A. Kessler and Lixin Kan

    Citation: Stem Cell Research & Therapy 2019 10:14

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