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Table 2 In vivo and Ex vivo image data

From: Stem cells labeled with superparamagnetic iron oxide nanoparticles in a preclinical model of cerebral ischemia: a systematic review with meta-analysis

Reference

 

Magnetic resonance image

HistologicaI image

MF (T)

Sequence

Weighted images (TR/TE;ms)

FOV; MT; ST

Results

Date (days)

Assay

Results

Date (days)

Wen et al. [33] (2014)

1.5

FSE

T2:2000/100

40; 256×256; 1mm

H+

7,14,21,28,35,42

PB; GFAP MAP2

H+

42

FFE

T2*:600/18.31

Shichinohe et al. [17] (2013)

7.0

Spin echo

T2:2500/60

30×30; 512×512; 1mm

H+

2,8,14,28,49

HE; TB; GFAP NeuN

H+

N/A

Tarulli et al. [32] (2013)

3.0

FSE

T2:8/70

30×30; 512×512; 1mm

H+

7,14

PB

H+

15

Zhang et al. [16] (2013)

7.0

N/A

N/A

N/A; N/A;

H+

1,2,3,4,5,6,7

PB

H+

N/A

Liu et al. [31] (2013)

3.0

GRE

T2*:2560/6.0

6.0; N/A; 1.6 mm

H+

1, 7,21

PB; BrdU;SOX-2

H+

7,21

Lu et al. [11] (2013)

3.0

T2WI

T2*: 5000/60

200;320×320; 2mm

H+

1, 7,14, 21, 28

HE; PB

H+

28

DWI

Kamiya et al. [30] (2013)

7.0

3D GRE

T2*: 100/10

50×50; 256×256; 5mm

H+

1h, 1, 3, 7

BB; PKH26

H+

7

T2WI

T2*: 2000/60

50×50; 256×128; 5mm

LL

Riegler et al. [13] (2012)

9.4

3D GRE

T2:6000/105

70×70; 512×512; 1mm

H+

24h

PB

H+

21

T2*:6000/105

Detante et al. [29] (2012)

2.35

SE-DW

DW:2000/80

N/A; 234×234; 1mm

H+

1, 15, 28

GFAP

H+

1, 15, 28

T2*:400/25

Tr+

Yang et al. [28] (2011)

3.0

MPGR

T2*:596/16

292×290; 0.7mm

H+

1,15

GFAP;PB

H+

N/A

Wang et al. [15] (2011)

3.0

N/A

T2: 5840/104

45×45; 256×256; 1.5mm

H+

1, 3

GFAP;PB

H+

1, 7, 30

Tr+

Tr+

Gutiérrez-Fernandez et al. [34] (2011)

7.0

RARE

T2

N/A

H+

24h, 14

NeuN

H+

N/A

LL

 

GFAP

LL

VEGF

Vandeputte et al. [21] (2010)

9.4

N/A

T2: N/A

N/A

H+

24H, 2-18

MAP2

H+

N/A

Tr+

Reddy et al. [12] (2010)

 

Turbo Spin echo

T2: 2128/80

230×230; 700×625, 1mm,

H+

4, 16

PB

H+

16

3.0

 

T2: 2548/80

80×80;94×94; 1.5mm

   

Tr+

DW: 4763/50

80×80;94×94; 1.5mm

Crabbe et al. [20] (2010)

9.4

2D MSME

T2: 6000/10; DW: 1500/27

4.0×4.0; 156×156; 0.8 mm

H+

12h, 10

MAP2

H+

N/A

N/A; N/A; 1mm

Tr+

Song et al. [27] (2009)

 

3D spin echo

T2: 3500/80

60×60; 256×160 2.0mm

N/A

N/A

N/A

N/A

N/A

PB

1.5

 

T2:50/20

80× 80; 256×160; 2mm

H+

−1, 1, 3, 7,14, 21, 28

NeuN

H+

1, 28

GFAP

Tr+

BrdU

Daadi et al. [26] (2009)

7.0

2D – spin echo

T2: 4000/82,5

5cm; 256×256; 0.6 mm

H+

2, 7, 14, 28, 60

hNSC

H+

60

LL

GFP

LL

NeuN

Lee et al. [19] (2009)

1.5

Turbo spin echo

T2: 2000/81

5cm; 512×512; 1.5mm

H+

−1, 1, 5, 12

hVim

H+

N/A

GRE

T2*: 280/20

fMSC

Tr+

Walczak et al. [25] (2008)

4.7 or 9.4

3D Spin echo

T2: 1300/98

34×22×11; 128×64×3; 0.35mm

H+

−1h, 2h-1

BrdU

H+

N/A

GRE

T2*: 300/5

10×16; 128×128

Tr+

Kim et al. [24] (2008)

4.7

3D Spin echo;

T1; N/A

4×3

H+

2, 7-70

hMSC

H+

Cell in core of lesion

RARE; Flash

T2: 600/14

256×192; 1mm

   

Tr+

T2*:758/30

Guzman et al. [23] (2008)

4.7

Spin echo

T2:2500/45

40; 256×256; 1mm

H+

−4, 3, 7,24

AP BrdU; GFAP; βTubulin

H+

N/A

3D GRE

T2*:600/5

Tr+

Rice et al. [14] (2007)

7.0 or 9.4

Spin-echo multislice

T2: 1,0; N/A

3.5cm; 128×128; 1mm

H+

24h, 14

fMSC

H+

N/A

GFP

Tr+

Jendelove et al. [18] (2004)

4.7

Turbo spin echo

T2:2000/42.5

3,5cm; 256×256; 0,5mm

H+

14-49

MSC*

H+

N/A

ESC

Tr+

GFP

 

Hoehn et al. [22] (2002)

7.0

2D Multislice

T2: 200/20

20×12×10 256×256×128; 0.5-0.7mm

H+

6, 8, 11, 16

ESC

H+

N/A

3D Flash

GFP

Tr+

  1. 2D, two-dimensional; 3D, three-dimensional; AP, acidic protein; BrdU, bromodeoxyuridine; DWI, diffusion weighted imaging; ESC, (mouse) embryonic stem cell; FFE, fast field echo; fMSC, fetal mesenchymal stem cell; FOV, field of vision; FSE, fast spin echo; GE, gradient echo ; GFAP, glial fibrillary acidic protein; GFP, green fluorescence protein; GRE, gradient echo; h, hour; HE, hematoxylin and eosin; hMSC, human mesenchymal stem cell; hNSC,human embryonic stem cell-derived human neural stem cell; H+, homing (migration to target site); hVim, human vimentin antibody; LL, loss lesion; MAP2, microtubule-associated with protein 2; MF, magnetic field; MPGR, multiplanar gradient recalled acquisition in the steady state; MSC, rat bone marrow stromal cell; MSME, 2D-Multislice-multiecho ; MT, matrix; N/A, not identified; NeuN, neuronal nuclei; PB, Prussian blue; SE, diffusion-weighted; ST, thickness; RARE, rapid acquisition with relaxation enhancement; T, Tesla; T2WI, -weighted magnetic resonance imaging; T2*, star weighted imaging; TB, Trypan blue; TE, echo time; TR, repetition time; Tr+, tracking (possibility of cellular trace).