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Figure 6 | Stem Cell Research & Therapy

Figure 6

From: Human hepatic stem cells transplanted into a fulminant hepatic failure Alb-TRECK/SCID mouse model exhibit liver reconstitution and drug metabolism capabilities

Figure 6

Functional assessments of humanized livers in Alb-TRECK/SCID mice. (A) Repopulation rates of human primary fetal liver cell (FLC)- and human hepatic stem cell (HpSC)-derived human hepatocytes in Alb-TRECK/SCID mice at about 8 weeks after transplantation. Results are means ± standard error of the mean (n = 12 and 14, respectively). (B) Serum human albumin (ALB) levels in mice with humanized livers derived from human primary FLCs and HpSCs at about 7 to 8 weeks after transplantation. Results are means ± standard error of the mean (n = 6/group). (C) Human-specific ketoprofen (KTP; CYP2C9) drug biotransformation in humanized Alb-TRECK/SCID mice at about 8 weeks after transplantation. (D) Analysis of human-specific CYP2D6-mediated debrisoquine (DEB) metabolism in human HpSC-derived humanized Alb-TRECK/SCID mice by metabolic ratios of the metabolite 4-hyroxydebrisoqune (4OH-DEB) to DEB. Results are means ± standard error of the mean (n ≥ 4/group). **P < 0.01, ***P < 0.001. ND, not detectable; NS, not significant; Sham, mice transplanted with saline.

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Stem Cell Research & Therapy

ISSN: 1757-6512