Table 2 Growth model parameters [9,29]
Parameter | Symbol | Value | Units |
|---|---|---|---|
Maximum proliferation rate of Lin− cells | u max | 6.26 | 1/day |
Maximum proliferation rate of Lin+ cells | u + | 0.204 | 1/day |
Maximal proliferation compartment | n max | 5.32 | – |
Proliferative decay term | D gr | 3.38 | – |
Self-renewal probability | f max | 0.634 | – |
Self-renewal decay term | D sr | 1.96 | – |
First SF1 Hill coefficient | k 1 | 0.614 | – |
Second SF1 Hill coefficient | k s | 1.08 | – |
SF2 Hill coefficient | k 2 | 0.555 | – |
SF3 Hill coefficient | k 3 | 0.625 | – |
SF4 Hill coefficient | k 4 | 0.533 | – |
SF1 concentration inducing 50% maximal SF2 secretion | L s | 0.915 | pg/ml |
Cell cycle Hill coefficient | k t | 5 | – |
Time for 50% of cells to enter cycle | Ï„ D | 2 | Days |
SF1 secretion rate | r 1 | 1.94 × 10−6 | pg/cell/day |
SF2 secretion rate | r 2 | 2.40 × 10−6 | pg/cell/day |
SF3 secretion rate | r 3 | 4.88 × 10−7 | pg/cell/day |
SF4 secretion rate | r 4 | 4.34 × 10−7 | pg/cell/day |