Figure 2
From: Mesenchymal stem cells-regulated Treg cells suppress colitis-associated colorectal cancer
MSCs decrease tumor incidence on day 70. (A) After AOM injection, animals were subjected to three cycles of DSS. MSCs (2 × 105) were injected at day 4 and day 25. Animals were sacrificed at day 33 and day 70. Colons were excised for macroscopic observation (B) and tumor numbers (C), tumor size (D) and colon length were assessed (E). The expression of Ki-67 (F and G) in the treated and untreated colons was examined by immunohistochemistry staining. Values are expressed as means ± SEM. *P <0.05, or **P <0.01. AOM, azomethane; DSS, dextran sulfate sodium; MSCs, mesenchymal stem cells; SEM, standard error of the mean.