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Table 3 Expression levels for regulated genes according to primary gene ontology function

From: Influence of vascular endothelial growth factor stimulation and serum deprivation on gene activation patterns of human adipose tissue-derived stromal cells

   Serum-deprived VEGF-stimulated
Gene ID Gene name FC 2 |FC| FC 2 |FC|
Proliferation     
SPRY1 Sprouty homolog 1, antagonist of FGF signaling +1.493 +2.815 NS NS
TEK TEK tyrosine kinase, endothelial +1.024 +2.033 NS NS
JAG1 Jagged 1 +0.8085 +1.751 +0.9621 +1.948
CDKN3 Cyclin-dependent kinase inhibitor 3 −1.668 −3.178 −1.386 −2.614
MKI67 Antigen identified by monoclonal antibody Ki-67 NS NS −1.222 −2.333
CCNB1 Cyclin B1 −1.324 −2.504 NS NS
HMOX1 Heme oxygenase (decycling) 1 −1.047 −2.066 −0.969 −1.957
TPX2 TPX2, microtubule-associated NS NS −1.042 −2.058
Secretome     
IGF1 Insulin-like growth factor 1 +1.963 +3.897 +1.999 +3.998
BMP6 Bone morphogenetic protein 6 +1.902 +3.738 +1.980 +3.944
TRIL TLR4 interactor with leucine-rich repeats +1.691 +3.229 +2.005 +4.013
PCSK5 Proprotein convertase subtilisin/kexin type 5 +1.091 +2.131 +1.480 +2.791
FGF9 Fibroblast growth factor 9 +1.044 +2.061 +0.871 +1.829
HGF Hepatocyte growth factor NS NS +0,9719 +1,961
PDGFD Platelet derived growth factor D +1.048 +2.067 +0.900 +1.866
GREM1 Gremlin 1, DAN family BMP antagonist −0.960 −1.946 −0.918 −1.891
TGF1 Transforming growth factor beta1 −0.962 −1.965 −0.908 −1.877
MME Membrane metallo-endopeptidase −1.322 −2.500 −1.432 −2.699
GREM2 Gremlin 2, DAN family BMP antagonist −2.326 −5.019 −2.425 −5.368
  1. Pre-defined groups. Fold changes (FC) and consequently calculated amount of up (+) or down (−) regulation (2|FC|) of significant genes (P < 0.05) compared to adipose tissue-derived stromal cells (ASCs) in complete medium are listed for vascular endothelial growth factor (VEGF)-treated and serum-deprived ASCs FC >0. 9. NS, not significant.