Parameters associated with inflammation and muscle degeneration analyzed on day 28 in peripheral blood of db/db mice injected with conditioned media from C2C12-Luc-GFP, C2C12-Luc-GFP-HO1 cells or non-conditioned control media. (A) Number of leukocytes. (B) Percentage of granulocytes. (C) Percentage of lymphocytes. (D) Percentage of monocytes. (E) Activity of creatine phosphokinase (CPK) in blood serum. Each bar represents mean + SEM (n = 5 to 6). *P < 0.05, versus control. WBC, white blood cell.