Effects of ex vivo exposure of healthy and chronic kidney disease bone marrow cells to pravastatin on renal morphology in chronic kidney disease recipients. (A) Focal glomerulosclerosis. (B) Tubulo-interstitial damage. CKD rats received healthy + DMEM BMCs (n = 5), healthy + pravastatin BMCs (n = 5), CKD + DMEM BMCs (n = 10) or CKD + pravastatin BMCs (n = 9). *P <0.1 versus healthy BMC recipients, $P <0.1 and $$P <0.05 versus CKD + DMEM BMC recipients. BMC, bone marrow cell; CKD, chronic kidney disease; DMEM, Dulbecco’s modified Eagle medium; FGS, focal glomerulosclerosis.