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Table 5 Glomerular and tubular histological characteristics after ex vivo pravastatin pre-treatment

From: Ex vivo exposure of bone marrow from chronic kidney disease donor rats to pravastatin limits renal damage in recipient rats with chronic kidney disease

 

Healthy + DMEM BMC recipients ( n = 5)

Healthy + pravastatin BMC recipients ( n = 5)

CKD + DMEM BMC recipients ( n = 10)

CKD + pravastatin BMC recipients ( n = 9)

Glomerular

    

 CD3

0.68 ± 0.34

0.72 ± 0.33

0.76 ± 0.19

0.67 ± 0.27

 ED-1

7.4 ± 1.0

5.0 ± 2.9

10.5 ± 5.5

7.9 ± 1.9

 Ki67

8.0 ± 0.76

6.4 ± 1.7

7.8 ± 1.8

7.8 ± 2.3

 TUNEL

2.6 ± 1.3

2.1 ± 1.3

7.0 ± 4.6

4.4 ± 3.7

 γH2AX

1.5 ± 1.6

0.6 ± 0.4

1.2 ± 0.8

1.4 ± 0.8

 GFP+

7.0 ± 6.6

2.5 ± 0.7

2.3 ± 1.9

5.2 ± 2.9

 JG12

42.5 ± 10

44.4 ± 9.9

42.8 ± 12.5

48.1 ± 9.0

Tubular

    

 CD3

81 ± 11

96 ± 45

122 ± 59

98 ± 27

 TUNEL

35 ± 24

65 ± 59

147 ± 116

95 ± 79

 γH2AX

5.0 ± 1.6

4.3 ± 2.0

6.1 ± 2.8

5.3 ± 1.5

 GFP+

83 ± 82

31 ± 24

23 ± 20

50 ± 38

  1. Data presented as mean ± standard deviation per 50 glomeruli or 20 tubular fields. BMC, bone marrow cell; CKD, chronic kidney disease; DMEM, Dulbecco’s modified Eagle medium; GFP, green fluorescent protein; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling.