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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: iTRAQ-based analysis of progerin expression reveals mitochondrial dysfunction, reactive oxygen species accumulation and altered proteostasis

Fig. 5

Effect of ROS scavengers on the autophagic proteolysis in PG-3T3L1 cells. a, b Western blot analysis of LC3 demonstrates a significant reduction in the LC3-II/LC3-I ratio in PG-3T3L1 cells incubated with 10 mM N-acetyl-cysteine (NAC) for 1 hour when compared with basal conditions. c, d Western-blot analysis of LC3 demonstrates a significant reduction in the LC3-II/LC3-I ratio in PG-3T3L1 cells incubated with 10 μM MitoTempo for 1 hour when compared with basal conditions. LC3 light chain 3, PG progerin

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Stem Cell Research & Therapy

ISSN: 1757-6512