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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Periostin enhances adipose-derived stem cell adhesion, migration, and therapeutic efficiency in Apo E deficient mice with hind limb ischemia

Fig. 5

Effects of periostin on adhesion and migration of ADSCs. More attached cells were observed in the P-ADSC group compared with those in the ADSC control and siRNA groups a, and quantitative assays indicated that periostin overexpression effectively enhanced the adhesion of ADSCs b. Migration assays of the ADSCs transfected with and without periostin and siRNA groups were conducted using a Boyden chamber c. Data indicate that periostin overexpression improved the migration of ADSCs d. Scale bar = 100 μm. Western blot analysis revealed upregulation and inhibition of the integrin-β1/FAK/Akt/PI3K/eNOS signaling pathway e. Significant differences were observed between the P-ADSC and ADSC groups and the siRNA group f. *P <0.05. ADSC adipose-derived stem cell, P-ADSC periostin-transfected ADSC, siRNA Small interfering RNA

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Stem Cell Research & Therapy

ISSN: 1757-6512