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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Hypoxia accelerates vascular repair of endothelial colony-forming cells on ischemic injury via STAT3-BCL3 axis

Fig. 8

Schematic representation of proposed mechanisms by which hypoxia increases clonogenic and proliferative potential, and enhances hypo-ECFC-mediated neovasculogenesis. Hypoxic preconditioning increases the clonogenic and proliferative potential of endothelial colony-forming cells (ECFCs) via the STAT3 pathway and augments the survival of ECFCs via STAT3-mediated BCL3 and vascular endothelial growth factor (VEGF) expression. These effects enhance ECFC-mediated neovasculogenesis in ischemic diseases

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Stem Cell Research & Therapy

ISSN: 1757-6512