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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Early severe impairment of hematopoietic stem and progenitor cells from the bone marrow caused by CLP sepsis and endotoxemia in a humanized mice model

Fig. 2

Analysis of human HSPC subpopulations in the murine bone marrow after induction of experimental sepsis. Eight weeks after transplantation of human umbilical cord blood CD34+ cells, mice were subjected to endotoxemia (40 μg of LPS intravenous) or cecal ligation and puncture surgery (CLP). Twenty-four hours later, bone marrow cells were harvested, counted, and stained with anti-human antibodies for flow cytometry analysis. Graphs in the upper panel (a, b, c, d) present results obtained in the model of endotoxemia, and graphs in the lower panel (e, f, g, h) impact of CLP on the human HSCPs. n = 6, *P < 0.05, **P < 0.01. C control, HSPC hematopoietic stem and progenitor cell, LPS lipopolysaccharide, TCC total cell count

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Stem Cell Research & Therapy

ISSN: 1757-6512