Fig. 2

Gene expression and epigenetic profiles of fibroblasts and iPSCs. a Dendrogram depicting unsupervised hierarchical clustering analysis of gene expression data from PBD-ZSD patient and healthy control skin fibroblasts and iPSCs. Analysis was based on log2-transformed gene expression scores from 575 probe sets with coefficient of variation (CV) greater than 0.25 and conducted using average linkage and Euclidean distance. Color bar represents log-2 transformed gene expression values. b Dendrogram depicting results of unsupervised hierarchical clustering analysis of DNA methylation data from PBD-ZSD patient and healthy control skin fibroblasts and iPSCs. Analysis was based on 4073 DNA methylation assays interrogating autosomal CpG loci with CV greater than 0.75 and the 10th largest and smallest β-value being greater than 0.6 and less than 0.4, respectively, in order to represent the most variable loci. Clustering was performed using average linkage and Pearson dissimilarity distance. Color bar represents β-values