Fig. 4

Metabolic signature of BCSC and SC subpopulations. a–d Gene expression in subpopulations of SCs was determined relative to corresponding benign tissue (n = 10). e–h Gene expression in subpopulations of malignant BCSCs was determined relative to corresponding tumor (n = 11). HIF-1α and nonglycolytic HIF-1α-inducible gene targets (red), HIF-1α-dependent glycolytic gene targets (purple), and HIF-1α-independent glycolytic gene targets (blue) are color coded. Significance was determined by Student’s paired t test with two-tailed distribution. Error bars represent the 95 % confidence interval. *p ≤0.05, **p ≤0.01 BCSC breast cancer stem/progenitor cell, SC benign breast stem/progenitor cell