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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: In vivo hepatogenic capacity and therapeutic potential of stem cells from human exfoliated deciduous teeth in liver fibrosis in mice

Fig. 8

Secondary transplantation of primary HLA-ABC-positive cells suppresses the activation of hepatic stellate cells and induction of Kupffer cells in livers CCl4-treated mice. ac Expression of alpha smooth muscle actin (αSMA). a Immunohistochemical staining with anti-αSMA antibody in recipient livers. b αSMA-positive area. c Real-time RT-PCR analysis of mouse αSMA (mαSMA) mRNA. d Real-time RT-PCR analysis of mouse MMP9 and MMP2 (mMMP9, mMMP2) and mouse TIMP1 and TIMP2 (mTIMP1, mTIMP2) mRNA in recipient livers. bd n = 5 for all groups. *P <0.05, **P <0.01, and ***P <0.005. ns no significance. Graph bars show the mean ± SD. Control, olive oil-injected group; CCl4, CCl4-treated group; CCl4 + HLA+, HLA+ cell-transplanted CCl4-treated group; CCl4 + HLA, HLA cell-transplanted CCl4-treated group. CCl 4 carbon tetrachloride, HLA human leukocyte antigen, MMP matrix metalloproteinase, TIMP tissue inhibitor of matrix metalloproteinase

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