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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Pre-differentiation of human neural stem cells into GABAergic neurons prior to transplant results in greater repopulation of the damaged brain and accelerates functional recovery after transient ischemic stroke

Fig. 8

Effect of treatment on endogenous neurogenesis and radial glial populations within the SVZ. Immunofluorescent images of proliferating cells (Ki67; red) and migrating immature neuroblasts (DCX; green) within the contralateral and ipsilateral SVZ of vehicle-treated (a, b), undifferentiated hNSC-treated (c, d), and predifferentiated cell-treated (e, f) animals. Nestin (green; arrowheads) and GFAP (red) immunopositive cells (coexpression giving a yellow appearance; arrows) within the contralateral and ipsilateral SVZ of vehicle-treated (g, h), undifferentiated treated (i, j), and predifferentiated treated (k, l) animals. All images were taken at the same anatomical location from animals with similar infarct volumes. Scale bar: (a–f) 500 μm, (g–l) 50 μm. CC corpus callosum, DCX doublecortin, GFAP glial fibrillary acidic protein, LV lateral ventricle, Prediff predifferentiated treated, Stm Striatum, Undiff undifferentiated hNSC treated

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Stem Cell Research & Therapy

ISSN: 1757-6512