Fig. 2
From: Aspirin promotes bone marrow mesenchymal stem cell-based calvarial bone regeneration in mini swine
Aspirin stimulates the osteogenesis of BMSC in vitro and in vivo. BMSC treated with different concentrations of aspirin increased the capability of forming Alizarin red-positive calcified deposits a. BMSC treated with 75 μg/ml aspirin showed the up-regulation of bone related genes (Runx2 and osteopontin) b. Aspirin treatment significantly stimulated BMSC-mediated bone formation in immunocompromised mice transplants c-e. The results are representative of at least three independent experiments. Results are expressed as mean ± standard deviation (SD) and statistical significance is shown as (*) p < 0.05 or (**) p < 0.01. Scale bars = 100 μm. B bone, HA hydroxyapatite/tricalcium phosphate, CT connective tissues, BMSC bone marrow mesenchymal stem cells