Table 1 Preclinical and clinical studies using adipose-derived stem cells and platelet-rich plasma

 ASCs

Human

Co-administration

Mouse full thickness wound model

Co-administration of PRP and ASCs in the wound beds increased ASC survival and enhanced arteriole formation in wounds

[20]

 ASCs

Rat (Wistar)

Co-administration

Osteonecrosis of the jaw

The combination of ASCs and PRP prevented frequency of bisphosphonate-related osteonecrosis of the jaw

[73]

 ASCs

Rabbit

Co-transplantation

Achilles tendon injured model

ASCs differentiated into tenocytes

[21]

 ASCs

Human

ASCs were treated with 15 % PRP in culture flask

Mouse model of articular cartilage injury

PRP-treated ASCs improved healing of injured articular cartilage

[72]

 ASCs

Rat (Fischer)

Co-transplantation

Rat calvarial defect

Regenerated volume of bone was significantly greater than in the PRP-treated group and ASCs/collagen gel-treated group 8 weeks after transplantation

[22]

 ASCs

Rat (Wistar)

Co-transplantation

Rat periodontal tissue defect

Alveolar bone, periodontal ligament-like structures, and cementum-like structures were observed in the periodontal tissue defect 8 weeks after transplantation

[18]

 ASCs

Canine

Co-transplantation

Canine periodontal tissue defect

Periodontal tissue regeneration was observed in the bifurcation defect 8 weeks after transplantation

[19]

 SVFs

Human

Co-transplantation

Rat periodontal tissue defect

Human SVFs have the potential to regenerate periodontal tissue

[24]

 ASCs

Human

Co-transplantation

Osteoarthritis

18 patients were treated. Intra-articular injection of a combination of ASCs and PRP effectively reduced pain and improved knee function in patients being treated for knee osteoarthritis

[74]

 SVFs

Human

Co-transplantation

Articular joints

91 patients were treated with autologous SVFs with PRP over 2 years

[75]