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Table 2 Relative expression of β2 integrin mRNA in activated CD3+ lymphocytes cultured in the absence or in the presence of MSC at three CD3/MSC ratios (20:1, 10:1, and 4:1)

From: Human mesenchymal stem cells target adhesion molecules and receptors involved in T cell extravasation

Treatments

Fold induction

Activated CD3+ cells

0.87 ± 0.28

Activated CD3+ cells + MSC 20:1

0.29 ± 0.33**

Activated CD3+ cells + MSC 10:1

0.30 ± 0.35**

Activated CD3+ cells + MSC 4:1

0.28 ± 0.18***

  1. mRNA expression was evaluated by qPCR, and values representing the mean ± SD of three different experiments are reported as fold induction with respect to controls (no activated CD3+ lymphocytes) after normalization for GAPDH mRNA. Significant differences: MSC-treated cells vs. activated cells, **p ≤0.01, ***p ≤0.001
  2. MSC mesenchymal stem cells
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Stem Cell Research & Therapy

ISSN: 1757-6512