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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Genetic modification of human mesenchymal stem cells helps to reduce adiposity and improve glucose tolerance in an obese diabetic mouse model

Fig. 4

a Adipose tissue derived MSC (ADMSCs) cells in high glucose (HG) show mitochondrial Complex 1 (NDUFS3) dysfunction compared to normal glucose (NG). Complex 2 used as a loading control. A: high glucose exposed, B: normal glucose exposed, C: cultured in HG media following SOD2 upregulation, D: cultured in NG media following SOD2 upregulation. On comparing Panel A (HG, no SOD2) and panel C (HG with SOD2) we demonstrate that SOD2 up-regulation prior to HG exposure rescues NDUFS3 band. b Bone marrow derived MSC cells in HG show mitochondrial Complex 1 (NDUFS3) dysfunction compared to NG. Complex 2 used as a loading control. A: High glucose exposed, B: Normal glucose exposed, C: cultured in HG media following SOD2 upregulation, D: cultured in NG media following SOD2 upregulation. On comparing Panel A (HG, no SOD2) and panel C (HG with SOD2) we demonstrate that SOD2 up-regulation prior to HG exposure rescues NDUFS3 band. SOD2 superoxide dismutase

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Stem Cell Research & Therapy

ISSN: 1757-6512