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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Promotion of human mesenchymal stem cell osteogenesis by PI3-kinase/Akt signaling, and the influence of caveolin-1/cholesterol homeostasis

Fig. 7

Proposed inhibitory feedback loop for MSC osteogenesis. We propose that phosphoinositide 3-kinase (PI3K)/Akt activation is a key signaling event required for the induction of osteogenesis in human bone marrow MSCs. As osteogenesis progresses, Cav-1 is upregulated as a negative feedback mechanism to suppress continued osteogenesis. PI3K/Akt signaling is one pathway that Cav-1 suppresses within caveolar membrane rafts to achieve this end, and as osteogenesis progresses more phosphorylated Akt (p-Akt) is translocated to this subcellular compartment

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Stem Cell Research & Therapy

ISSN: 1757-6512