| |
Sham
|
TNBS
|
TNBS + BM-MSC
|
TNBS + AT-MSC
|
|---|
| |
Total number of myenteric neurons/2 mm2
|
|
24 h
|
263.8 ± 3.5
|
202.5 ± 8.4 ††††
|
258.8 ± 2.9 ****
|
242.8 ± 6.2 *** †
|
|
72 h
|
262.0 ± 5.1
|
204.0 ± 5.4 †††
|
258.8 ± 7.6 **
|
240.5 ± 10.0 ** †
|
| |
Total number of nNOS-IR neurons/2 mm2
|
|
24 h
|
52.3 ± 1.8
|
70.0 ± 4.9 †††
|
55.0 ± 3.2 **
|
53.5 ± 2.6 **
|
|
72 h
|
52.5 ± 1.0
|
70.5 ± 3.2 †††
|
55.3 ± 2.7 **
|
57.3 ± 1.7 *
|
| |
Proportion of nNOS-IR neurons/2 mm2 (%)
|
|
24 h
|
19.9 ± 0.9
|
34.8 ± 2.8 ††††
|
21.3 ± 1.2 ****
|
22.1 ± 1.1 ****
|
|
72 h
|
20.2 ± 0.3
|
34.6 ± 1.8 ††††
|
21.4 ± 1.3 ****
|
23.9 ± 0.7 ***
|
| |
Total number of ChAT-IR neurons/2 mm2
|
|
24 h
|
163.5 ± 2.1
|
111.3 ± 5.7 ††††
|
148.3 ± 4.6 ****
|
144.5 ± 4.9 *** †
|
|
72 h
|
157.8 ± 6.3
|
112.3 ± 1.7 ††††
|
147.5 ± 7.3 ****
|
145.3 ± 3.4 ***
|
| |
Proportion of ChAT-IR neurons/2 mm2 (%)
|
|
24 h
|
62.0 ± 1.4
|
55.1 ± 2.9
|
57.3 ± 1.6
|
59.5 ± 0.9
|
|
72 h
|
59.1 ± 0.9
|
55.2 ± 2.3
|
57.1 ± 3.0
|
60.7 ± 2.5
|
-
TNBS 2,4,6-trinitrobenzene sulfonic acid, BM-MSC bone marrow-derived MSC, AT-MSC adipose tissue-derived MSC, MSC mesenchymal stem cell, nNOS neuronal nitric oxide synthase, ChAT choline acetyltransferase, IR immunoreactive
- *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, significantly different to TNBS; †p < 0.05, †††p < 0.001, ††††p < 0.0001, significantly different to sham
