Skip to main content

Table 2 Effects of mesenchymal stem cells derived from bone marrow and adipose tissue on myenteric neurons in TNBS-induced colitis

From: Human adult stem cells derived from adipose tissue and bone marrow attenuate enteric neuropathy in the guinea-pig model of acute colitis

  Sham TNBS TNBS + BM-MSC TNBS + AT-MSC
  Total number of myenteric neurons/2 mm2
24 h 263.8 ± 3.5 202.5 ± 8.4 †††† 258.8 ± 2.9 **** 242.8 ± 6.2 *** †
72 h 262.0 ± 5.1 204.0 ± 5.4 ††† 258.8 ± 7.6 ** 240.5 ± 10.0 ** †
  Total number of nNOS-IR neurons/2 mm2
24 h 52.3 ± 1.8 70.0 ± 4.9 ††† 55.0 ± 3.2 ** 53.5 ± 2.6 **
72 h 52.5 ± 1.0 70.5 ± 3.2 ††† 55.3 ± 2.7 ** 57.3 ± 1.7 *
  Proportion of nNOS-IR neurons/2 mm2 (%)
24 h 19.9 ± 0.9 34.8 ± 2.8 †††† 21.3 ± 1.2 **** 22.1 ± 1.1 ****
72 h 20.2 ± 0.3 34.6 ± 1.8 †††† 21.4 ± 1.3 **** 23.9 ± 0.7 ***
  Total number of ChAT-IR neurons/2 mm2
24 h 163.5 ± 2.1 111.3 ± 5.7 †††† 148.3 ± 4.6 **** 144.5 ± 4.9 *** †
72 h 157.8 ± 6.3 112.3 ± 1.7 †††† 147.5 ± 7.3 **** 145.3 ± 3.4 ***
  Proportion of ChAT-IR neurons/2 mm2 (%)
24 h 62.0 ± 1.4 55.1 ± 2.9 57.3 ± 1.6 59.5 ± 0.9
72 h 59.1 ± 0.9 55.2 ± 2.3 57.1 ± 3.0 60.7 ± 2.5
  1. TNBS 2,4,6-trinitrobenzene sulfonic acid, BM-MSC bone marrow-derived MSC, AT-MSC adipose tissue-derived MSC, MSC mesenchymal stem cell, nNOS neuronal nitric oxide synthase, ChAT choline acetyltransferase, IR immunoreactive
  2. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, significantly different to TNBS; †p < 0.05, †††p < 0.001, ††††p < 0.0001, significantly different to sham