Fig. 4

Effects of guinea pig MSC treatments on histological changes and body weight in colitis. Colonic structure was assessed via haematoxylin-and-eosin staining of cross-sections from tissues collected at 24 h (a–d) and 72 h (a′-d′) after TNBS administration. Scale bar = 50 μm. e Body weight was recorded at 24, 48 and 72 h after TNBS administration and is expressed as the change from baseline measurements. *P <0.05, **P <0.01, ***P <0.001, ****P <0.0001, significantly different between groups; ^††† P <0.001, ^†††† P <0.0001, significantly different from baseline weight within groups, n = 4 animals per group per time point. gpAT-MSC guinea pig adipose tissue-derived mesenchymal stem cell, gpBM-MSC guinea pig bone marrow-derived mesenchymal stem cell, MSC mesenchymal stem cell, TNBS 2,4,6-trinitrobenzene sulfonic acid