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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway

Fig. 2

MSCs reduced HPMEC permeability by secreting paracrine VEGF and HGF. The result showed that MSC-CM treatment reduced LPS-induced endothelial paracellular permeability; however, the effect of MSC-CM treatment was significantly blocked by anti-HGF antibody (p < 0.05 and p < 0.01; a). Meanwhile, MSC-CM treatment reduced LPS-induced transcellular permeability (b), and the effect of MSC-CM treatment was significantly blocked by anti-HGF antibody or anti-VEGF antibody. Furthermore, the role of MSCs in reducing transcellular permeability was clearly inhibited by anti-HGF and anti-VEGF antibodies. Adding MSC-CM in all groups except control group and LPS group. n = 3, *p < 0.01 vs control group; # p < 0.01 vs LPS group; &p < 0.05; $ p < 0.01 vs MSC-CM group. CM Conditioned medium, HGF Hepatocyte growth factor, LPS Lipopolysaccharide, MSC Mesenchymal stem cell, VEGF Vascular endothelial growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512