Table 1 Advantages and disadvantages of different mouse models
From: “Mouse Clone Model” for evaluating the immunogenicity and tumorigenicity of pluripotent stem cells
Mouse models | Features | Advantages | Disadvantages |
|---|---|---|---|
Inbred mouse strain model | Nearly identical to each other genetically | Many different strains are available, such as C57BL/6, etc. | Not exactly the same with each other genetically and have the potential to induce immune reaction |
Immunodeficient mouse model [29] | Deficient immune system for various reasons | Many different strains are available, such as nude-mice strains, etc. | Some transplanted stem cells might result in tumors due to the weakened immune system |
“Mouse Clone Model” | Theoretically identical with each other, and exactly the same between transplanted stem cells and mouse recipients | In theory, no immune rejection reaction, and cannot form tumor due to the normal immune system | Need tedious work and high techniques to generate a clone of mice |