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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

Fig. 8

Noggin treatment only during OPA1 +/−-iPSC differentiation into neural rosettes could rescue OPA1 +/−-RGC generation. Control and VO-iPSCs were incubated with 100 ng/mL Noggin in the cell culture medium only during the differentiation of neural rosettes and Noggin was removed in afterward differentation. Cells were fixed with 4 % PFA on day 31. Upper panel, TUJ1 (green) and BRN3a (red) staining are shown. Lower panel, TUJ1 (green) and ISLET-1 (red) staining are shown. Scale bars = 100 μM. Data from the control under the same treatment are not shown

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Stem Cell Research & Therapy

ISSN: 1757-6512