Fig. 1
From: Hematopoietic stem cell transplantation for multiple sclerosis: is it a clinical reality?
Hematopoietic hierarchy model. Hematopoietic stem cells (HSCs) are divided into long-term (LT)-HSC and short-term (ST)-HSC types. A LT-HSC with long-term self-renewal activity is converted into a ST-HSC and then HSCs give rise to a multipotent progenitor (MPP). A MPP commits in bone marrow to become either common myeloid progenitor (CMP) or common lymphoid progenitor (CLP). The CMP and CLP give rise to mature blood cells in peripheral blood, such as granulocytes, red blood cells (RBC), platelets, monocytes, T cells, B cells, and natural killer (NK) cells [7]