Fig. 3
From: BET protein inhibitor JQ1 inhibits growth and modulates WNT signaling in mesenchymal stem cells
JQ1 arrested MSCs in the G1 phase of the cell cycle. Cell cycle profile of MSCs treated with DMSO and 0, 10, 100, and 500 nM JQ1 for 24 hours, stained with PI. Mean cell population percentage ± SEM (n = 3). Analysis was performed using ModFit software (Verity Software House, Topsham, ME, USA). Shown are histogram and graphical representations of cells in the G0/G1, S, and G2/M phases of cell cycle (a and b, respectively). *p ≤0.05. DMSO dimethyl sulfoxide, JQ1 (S)-tert-butyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate