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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

Fig. 4

Metabolic and differentiation activities in chondrogenically-induced hMSCs upon administration of rAAV vectors. hMSC aggregates were transduced with the various vectors or vector combinations as described in Fig. 1 and in Methods. Samples were histologically and histomorphometrically processed after 21 days to evaluate cellularity (H & E staining; magnification × 20) a, b and the deposition of matrix proteoglycans (toluidine blue staining; magnification × 4) a, c and type II collagen (magnification × 4) a, d as described in Methods (all representative data). *,**Statistically significant compared with group 1 (rAAV-lacZ) (*P ≤0.050; **P ≤0.010). H & E hematoxylin and eosin, TGF-β transforming growth factor beta

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Stem Cell Research & Therapy

ISSN: 1757-6512