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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells

Fig. 3

Participation of select tumor suppressor genes and an EMT factor in HPC/HSC reprogramming. a Kinetics of expression of indicated genes in the OSKM-mediated reprogramming of HPC/HSCs and MEFs (n = 3 measurements). Error bars indicate the SD. b, c Ectopic activation of indicated genes during the reprogramming process of HPC/HSCs. d AP staining results for ectopic activation of p21, Ink4b, Ink4a, Arf, and Snail1 in the OSKM-mediated reprogramming of HPC/HSCs. e Reprogramming efficiencies of the indicated genotypes relative to wild-type (WT) in HPC/HSCs (n = 3 measurements). Error bars indicate the SD. *P <0.05, **P <0.01, unpaired t test. D day, HPC/HSC hematopoietic progenitor and stem cell, MEF mouse embryonic fibroblast

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